Obesity-induced cardiac lipid accumulation in adult mice is modulated by G protein-coupled receptor kinase 2 levels.

scientific article published on 10 November 2016

Obesity-induced cardiac lipid accumulation in adult mice is modulated by G protein-coupled receptor kinase 2 levels. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1005490928
P356DOI10.1186/S12933-016-0474-6
P932PMC publication ID5105284
P698PubMed publication ID27832814

P50authorCristina MurgaQ88734451
Victoria CachofeiroQ42731331
P2093author name stringFederico Mayor
Marta Cruces-Sande
Alba C Arcones
Elisa Lucas
Rocio Vila-Bedmar
P2860cites workMitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins.Q53541654
Optimisation of oil red O staining permits combination with immunofluorescence and automated quantification of lipidsQ74294396
Degradation of the G protein-coupled receptor kinase 2 by the proteasome pathwayQ77696868
Adapted changes in left ventricular structure and function in severe uncomplicated obesityQ80984809
Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathyQ26775037
Structural Basis for the Regulation of Protein Kinase A by Activation Loop PhosphorylationQ27677271
Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in miceQ28272272
Beta-arrestin- and c-Src-dependent degradation of G-protein-coupled receptor kinase 2Q28359741
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133Q29617856
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G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failureQ30487539
Lipotoxicity in the heartQ33665107
Mitochondrial and cellular mechanisms for managing lipid excessQ33978623
Epicardial and perivascular adipose tissues and their influence on cardiovascular disease: basic mechanisms and clinical associations.Q34297183
Lipoapoptosis: its mechanism and its diseasesQ35047180
G-protein-coupled receptor kinase 2-mediated desensitization of adiponectin receptor 1 in failing heartQ35528402
G protein-coupled receptor kinase 2 plays a relevant role in insulin resistance and obesityQ35757227
Modern science versus the stigma of obesityQ35788028
Adaptive and maladaptive hypertrophic pathways: points of convergence and divergenceQ35846888
The evolving impact of g protein-coupled receptor kinases in cardiac health and diseaseQ36000382
Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2.Q36100307
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Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, PhQ36354637
Insulin treatment increases myocardial ceramide accumulation and disrupts cardiometabolic functionQ36383552
GRK2 compromises cardiomyocyte mitochondrial function by diminishing fatty acid-mediated oxygen consumption and increasing superoxide levelsQ36399800
The pathogenesis of insulin resistance: integrating signaling pathways and substrate fluxQ36430696
Adiposity of the heart, revisitedQ36439598
Adipose tissue biology and cardiomyopathy: translational implicationsQ36496035
Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic MiceQ36548326
Lipotoxic heart disease in obese rats: implications for human obesityQ37117677
GRK mythology: G-protein receptor kinases in cardiovascular diseaseQ37396870
AMPK activation, a preventive therapeutic target in the transition from cardiac injury to heart failureQ37834161
Obesity-associated insulin resistance in skeletal muscle: role of lipid accumulation and physical inactivity.Q37845219
G Protein-coupled receptor kinase 2 (GRK2): A novel modulator of insulin resistanceQ37880070
G protein-coupled receptor kinases in normal and failing myocardiumQ37881660
PGC-1 coactivators in the cardiovascular system.Q37952044
Current mapping of obesityQ38134787
The pathophysiology of heart failure with preserved ejection fraction.Q38222648
Downregulation of G protein-coupled receptor kinase 2 levels enhances cardiac insulin sensitivity and switches on cardioprotective gene expression patternsQ38304071
Cardiac myocyte apoptosis is associated with increased DNA damage and decreased survival in murine models of obesityQ38317857
Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity.Q38321475
Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in miceQ38352186
Cardiac lipid accumulation associated with diastolic dysfunction in obese mice.Q38352512
Mitochondrial dynamics, mitophagy and cardiovascular disease.Q38625440
AMP-activated protein kinase phosphorylates transcription factors of the CREB familyQ40038541
Protein-tyrosine phosphatase 1B-deficient myocytes show increased insulin sensitivity and protection against tumor necrosis factor-alpha-induced insulin resistanceQ40177903
Short Term Palmitate Supply Impairs Intestinal Insulin Signaling via Ceramide ProductionQ42395469
GRK2 contribution to the regulation of energy expenditure and brown fat functionQ42505116
Mechanism of beta-adrenergic receptor desensitization in cardiac hypertrophy is increased beta-adrenergic receptor kinaseQ44771333
Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted miceQ47859877
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectobesityQ12174
G protein-coupled receptorQ38173
P304page(s)155
P577publication date2016-11-10
P1433published inCardiovascular DiabetologyQ2468083
P1476titleObesity-induced cardiac lipid accumulation in adult mice is modulated by G protein-coupled receptor kinase 2 levels
P478volume15

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Q91823408A high-content, in vitro cardiac fibrosis assay for high-throughput, phenotypic identification of compounds with anti-fibrotic activity
Q55261192Biochemical and Ultrastructural Cardiac Changes Induced by High-Fat Diet in Female and Male Prepubertal Rabbits.
Q64229774G Protein-Coupled Receptor Kinase 2 (GRK2) as a Potential Therapeutic Target in Cardiovascular and Metabolic Diseases
Q45874891GRK2 as a therapeutic target for heart failure
Q47649685Inhibition of galectin-3 ameliorates the consequences of cardiac lipotoxicity in a rat model of diet-induced obesity.
Q39159635Insulin and β Adrenergic Receptor Signaling: Crosstalk in Heart
Q46034115Myocyte membrane and microdomain modifications in diabetes: determinants of ischemic tolerance and cardioprotection.
Q89506074Potential mechanisms responsible for cardioprotective effects of sodium-glucose co-transporter 2 inhibitors
Q90411593Restricting mitochondrial GRK2 post-ischemia confers cardioprotection by reducing myocyte death and maintaining glucose oxidation
Q64090294Soluble Receptor for Advanced Glycation End Products: A Protective Molecule against Intramyocardial Lipid Accumulation in Obese Zucker Rats?
Q39107039Targeting GPCR-Gβγ-GRK2 signaling as a novel strategy for treating cardiorenal pathologies
Q61444355The Impact of Cardiac Lipotoxicity on Cardiac Function and Mirnas Signature in Obese and Non-Obese Rats with Myocardial Infarction

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