A Transcriptional Signature Identifies LKB1 Functional Status as a Novel Determinant of MEK Sensitivity in Lung Adenocarcinoma.

scientific article published on 7 November 2016

A Transcriptional Signature Identifies LKB1 Functional Status as a Novel Determinant of MEK Sensitivity in Lung Adenocarcinoma. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/0008-5472.CAN-16-1639
P932PMC publication ID7027166
P698PubMed publication ID27821489

P50authorTadaaki YamadaQ55070023
P2093author name stringDavid P Carbone
Joseph M Amann
Kyungho Park
Cynthia D Timmers
Jacob M Kaufman
P2860cites workDifferential association of STK11 and TP53 with KRAS mutation-associated gene expression, proliferation and immune surveillance in lung adenocarcinoma.Q36814030
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MEK inhibition in non-small cell lung cancerQ38254501
Heightening Energetic Stress Selectively Targets LKB1-Deficient Non-Small Cell Lung CancersQ38819110
LKB1 Loss induces characteristic patterns of gene expression in human tumors associated with NRF2 activation and attenuation of PI3K-AKT.Q38994951
Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitisQ39659924
MultiRankSeq: multiperspective approach for RNAseq differential expression analysis and quality controlQ40727604
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LKB1/KRAS mutant lung cancers constitute a genetic subset of NSCLC with increased sensitivity to MAPK and mTOR signalling inhibitionQ43188970
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Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumorsQ24614112
Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutationsQ24632064
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stressQ24633606
Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and CufflinksQ24633890
Three-stage quality control strategies for DNA re-sequencing dataQ26864378
Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilitiesQ27345462
A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic responseQ27851728
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The LKB1 tumor suppressor negatively regulates mTOR signalingQ28272728
Uncoupling of the LKB1-AMPKalpha energy sensor pathway by growth factors and oncogenic BRAFQ28474973
Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2Q28509303
Differential pathogenesis of lung adenocarcinoma subtypes involving sequence mutations, copy number, chromosomal instability, and methylationQ28730029
Apoptosis Induction by MEK Inhibition in Human Lung Cancer Cells Is Mediated by BimQ28749134
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivityQ29547693
Systematic identification of genomic markers of drug sensitivity in cancer cellsQ29547695
The LKB1-AMPK pathway: metabolism and growth control in tumour suppressionQ29617506
LKB1 modulates lung cancer differentiation and metastasisQ30080027
Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.Q30384542
Multi-perspective quality control of Illumina exome sequencing data using QC3.Q30794236
FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesisQ34504786
Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.Q34546258
mTOR Kinase Inhibition Causes Feedback-Dependent Biphasic Regulation of AKT SignalingQ35581650
LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenforminQ36630561
Metformin increases antitumor activity of MEK inhibitors through GLI1 downregulation in LKB1 positive human NSCLC cancer cellsQ36782414
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectadenocarcinomaQ356033
P304page(s)153-163
P577publication date2016-11-07
P1433published inCancer ResearchQ326097
P1476titleA Transcriptional Signature Identifies LKB1 Functional Status as a Novel Determinant of MEK Sensitivity in Lung Adenocarcinoma
P478volume77

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cites work (P2860)
Q48015155Gemcitabine and Chk1 Inhibitor AZD7762 Synergistically Suppress the Growth of Lkb1-Deficient Lung Adenocarcinoma
Q47592558Histone Deacetylase Inhibition Enhances the Antitumor Activity of a MEK Inhibitor in Lung Cancer Cells Harboring RAS Mutations.
Q57232070Mutations and PD-1 Inhibitor Resistance in -Mutant Lung Adenocarcinoma
Q97529523Regulation of cancer cell metabolism: oncogenic MYC in the driver's seat
Q47151535STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell lines
Q57810318Sorafenib in Combination with Betulinic Acid Synergistically Induces Cell Cycle Arrest and Inhibits Clonogenic Activity in Pancreatic Ductal Adenocarcinoma Cells
Q92297313Targeting metabolism to regulate immune responses in autoimmunity and cancer

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