In vivo and in vitro effects of a novel anti-Dkk1 neutralizing antibody in multiple myeloma.

scientific article published on 17 January 2013

In vivo and in vitro effects of a novel anti-Dkk1 neutralizing antibody in multiple myeloma. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BONE.2013.01.012
P932PMC publication ID4163545
P698PubMed publication ID23333523

P50authorKishan J PatelQ56929356
David T ScaddenQ88652265
Kenneth C. AndersonQ28421846
Samantha PozziQ42399984
P2093author name stringMariateresa Fulciniti
Teru Hideshima
Noopur Raje
Nikhil Munshi
Hua Yan
Sonia Vallet
Henry M Kronenberg
Diana Cirstea
Loredana Santo
Homare Eda
Stuart Kuhstoss
Linda Schirtzinge
P2860cites workDKK1 correlates with response and predicts rapid relapse after autologous stem cell transplantation in multiple myelomaQ43247985
Serum concentrations of DKK-1 decrease in patients with multiple myeloma responding to anti-myeloma treatmentQ43844308
Serum concentrations of DKK-1 correlate with the extent of bone disease in patients with multiple myeloma.Q52919769
Pathogenesis of myeloma bone disease.Q55052458
Serum concentrations of Dickkopf-1 protein are increased in patients with multiple myeloma and reduced after autologous stem cell transplantationQ57904871
The effects of Dickkopf-1 antibody on metaphyseal bone and implant fixation under different loading conditionsQ63248240
Canonical Wnt signaling in osteoblasts is required for osteoclast differentiationQ79872865
A high-affinity fully human anti-IL-6 mAb, 1339, for the treatment of multiple myelomaQ24646864
Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myelomaQ24669938
Wnt signaling in B-cell neoplasiaQ28182311
The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myelomaQ28236113
Inhibition of Wnt activity induces heart formation from posterior mesodermQ28346509
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiationQ28505419
Dickkopf-1 is a member of a new family of secreted proteins and functions in head inductionQ29616164
Differential expression of DKK-1 binding receptors on stromal cells and myeloma cells results in their distinct response to secreted DKK-1 in myelomaQ34174284
Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo.Q34346883
Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivoQ35642745
MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts.Q36141697
Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivoQ36478430
Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinomaQ36547263
Characterization of Wnt/beta-catenin signalling in osteoclasts in multiple myelomaQ36932713
The role of Dickkopf-1 in bone development, homeostasis, and diseaseQ37066218
WNT/beta-catenin signaling is involved in regulation of osteoclast differentiation by human immunodeficiency virus protease inhibitor ritonavir: relationship to human immunodeficiency virus-linked bone mineral lossQ37073777
Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myelomaQ37271048
Osteogenic differentiation of mesenchymal stem cells in multiple myeloma: identification of potential therapeutic targets.Q37484765
Targeting Wnt signaling: can we safely eradicate cancer stem cells?Q37763415
Advances in the biology and treatment of bone disease in multiple myelomaQ37853737
Wnt inhibitor Dickkopf-1 as a target for passive cancer immunotherapyQ39692668
Suppression of Wnt signaling by Dkk1 attenuates PTH-mediated stromal cell response and new bone formationQ39741986
Inhibiting Dickkopf-1 (Dkk1) removes suppression of bone formation and prevents the development of osteolytic bone disease in multiple myeloma.Q39915275
High-dose zoledronic acid impacts bone remodeling with effects on osteoblastic lineage and bone mechanical propertiesQ39948712
Knocking down dickkopf-1 alleviates estrogen deficiency induction of bone loss. A histomorphological study in ovariectomized ratsQ40277043
Wnt signalling in osteoblasts regulates expression of the receptor activator of NFkappaB ligand and inhibits osteoclastogenesis in vitroQ40307786
P433issue2
P921main subjectantibodyQ79460
P304page(s)487-496
P577publication date2013-01-17
P1433published inBoneQ15755003
P1476titleIn vivo and in vitro effects of a novel anti-Dkk1 neutralizing antibody in multiple myeloma
P478volume53

Reverse relations

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Q88717532DKK1 and Kremen Expression Predicts the Osteoblastic Response to Bone Metastasis
Q39044797DKK1 promotes hepatocellular carcinoma cell migration and invasion through β-catenin/MMP7 signaling pathway
Q34049686Dickkopf-1 is a key regulator of myeloma bone disease: opportunities and challenges for therapeutic intervention
Q39090721Emerging treatment approaches for myeloma-related bone disease
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Q27021939Immunotherapy strategies for multiple myeloma: the present and the future
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Q40111192Regulation of Sclerostin Expression in Multiple Myeloma by Dkk-1: A Potential Therapeutic Strategy for Myeloma Bone Disease
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Q38128460Wnt signalling in osteoporosis: mechanisms and novel therapeutic approaches

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