Hand2 inhibits kidney specification while promoting vein formation within the posterior mesoderm

scientific article published on 2 November 2016

Hand2 inhibits kidney specification while promoting vein formation within the posterior mesoderm is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.7554/ELIFE.19941
P8608Fatcat IDrelease_ofzuf24tj5borguc2ub7ke7tou
P932PMC publication ID5132343
P698PubMed publication ID27805568

P50authorElliot A PerensQ57321644
Zayra V Garavito-AguilarQ59189050
Deborah YelonQ88020218
Gina P Guio-VegaQ96049283
Karen T PeñaQ96049284
Yocheved L SchindlerQ96049285
P2093author name stringElliot A Perens
Deborah Yelon
Zayra V Garavito-Aguilar
Gina P Guio-Vega
Karen T Peña
Yocheved L Schindler
P2860cites workp53 activation by knockdown technologiesQ21563456
The surface ectoderm is essential for nephric duct formation in intermediate mesodermQ22008755
Bmp signaling promotes intermediate mesoderm gene expression in a dose-dependent, cell-autonomous and translation-dependent mannerQ24338835
Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalitiesQ24651500
Morphogen rules: design principles of gradient-mediated embryo patterningQ26775531
Single-gene causes of congenital anomalies of the kidney and urinary tract (CAKUT) in humansQ26862475
Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2Q28506661
Odd-skipped related 1 is required for development of the metanephric kidney and regulates formation and differentiation of kidney precursor cellsQ28510236
Odd-skipped related 1 (Odd 1) is an essential regulator of heart and urogenital developmentQ28512164
Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA bindingQ28588909
The bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidednessQ28591545
Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHANDQ28592248
Osr1 expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osr1-dependent nephron progenitor compartment within the mammalian kidneyQ28594297
Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signalsQ47074199
Targeted deletion of a branchial arch-specific enhancer reveals a role of dHAND in craniofacial developmentQ47614302
Cranial vasculature in zebrafish forms by angioblast cluster-derived angiogenesisQ51900109
Conservation of sequence and expression of Xenopus and zebrafish dHAND during cardiac, branchial arch and lateral mesoderm development.Q52166643
The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development.Q52168461
Synergism between Pax-8 and lim-1 in embryonic kidney development.Q52174456
High frequency of kidney and urinary tract anomalies in asymptomatic first-degree relatives of patients with CAKUTQ62937752
Signals from trunk paraxial mesoderm induce pronephros formation in chick intermediate mesodermQ73556382
Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathwayQ73685420
Lim1 activity is required for intermediate mesoderm differentiation in the mouse embryoQ73918717
Patterning of the avian intermediate mesoderm by lateral plate and axial tissuesQ78684881
Duplication of chromosome 4q: renal pathology of two siblingsQ81442508
Arterial and venous progenitors of the major axial vessels originate at distinct locationsQ30542927
The bHLH transcription factor hand2 plays parallel roles in zebrafish heart and pectoral fin developmentQ30872704
The cdx genes and retinoic acid control the positioning and segmentation of the zebrafish pronephrosQ33303450
Zebrafish whole mount high-resolution double fluorescent in situ hybridizationQ33422268
Hand2 ensures an appropriate environment for cardiac fusion by limiting Fibronectin functionQ34107608
A variant OSR1 allele which disturbs OSR1 mRNA expression in renal progenitor cells is associated with reduction of newborn kidney size and function.Q34206356
Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration.Q34341296
Hedgehog signaling plays a cell-autonomous role in maximizing cardiac developmental potentialQ34421441
Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesisQ34673674
HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchymeQ35170396
Targeted deletion of Hand2 in enteric neural precursor cells affects its functions in neurogenesis, neurotransmitter specification and gangliogenesis, causing functional aganglionosisQ35306096
HNF1B and PAX2 mutations are a common cause of renal hypodysplasia in the CKiD cohortQ35670536
Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cellsQ36245444
A role for Vg1/Nodal signaling in specification of the intermediate mesodermQ36752969
Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumorQ36826291
lim6, a novel LIM homeobox gene in the zebrafish: comparison of its expression pattern with lim1.Q36877483
Severe prenatal renal anomalies associated with mutations in HNF1B or PAX2 genes.Q36980350
DNA binding-dependent and -independent functions of the Hand2 transcription factor during mouse embryogenesisQ37306914
odd skipped related1 reveals a novel role for endoderm in regulating kidney versus vascular cell fateQ37342893
Boundary formation and maintenance in tissue developmentQ37821751
Cadherin-17 is required to maintain pronephric duct integrity during zebrafish development.Q38288571
Foxn4 directly regulates tbx2b expression and atrioventricular canal formationQ38292640
Wt1a, Foxc1a, and the Notch mediator Rbpj physically interact and regulate the formation of podocytes in zebrafishQ38594630
Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cellsQ39206582
Endoderm-derived Sonic hedgehog and mesoderm Hand2 expression are required for enteric nervous system development in zebrafish.Q39413846
Expression of the zebrafish paired box gene pax[zf-b] during early neurogenesisQ41818633
Hand2 regulates extracellular matrix remodeling essential for gut-looping morphogenesis in zebrafishQ41921790
Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regenerationQ42050363
Odd skipped related 1 is a negative feedback regulator of nodal-induced endoderm developmentQ43083653
Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1.Q44645454
Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidneyQ45178758
Spatial and temporal expression of the zebrafish genome by large-scale in situ hybridization screening.Q45189517
Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cellsQ46405604
EphA4 is required for cell adhesion and rhombomere-boundary formation in the zebrafish.Q46409666
Odd-skipped genes encode repressors that control kidney development.Q47070410
Two endothelin 1 effectors, hand2 and bapx1, pattern ventral pharyngeal cartilage and the jaw joint.Q47073324
BMP signaling restricts hemato-vascular development from lateral mesoderm during somitogenesisQ47073586
P407language of work or nameEnglishQ1860
P577publication date2016-11-02
P1433published ineLifeQ2000008
P1476titleHand2 inhibits kidney specification while promoting vein formation within the posterior mesoderm
P478volume5

Reverse relations

Q59711091A conserved regulatory program drives emergence of the lateral plate mesodermcites workP2860