Applying fluid biomarkers to Alzheimer's disease

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Applying fluid biomarkers to Alzheimer's disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPCELL.00007.2017
P932PMC publication ID5538797
P698PubMed publication ID28424166

P50authorHenrik ZetterbergQ6252048
P2860cites workDetection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease.Q53417610
Plasma amyloid β-quo vadis?Q53478803
Limited role of free TDP-43 as a diagnostic tool in neurodegenerative diseasesQ58292492
Chemokines in CSF of Alzheimer's disease patientsQ59387647
Soluble TREM-2 in cerebrospinal fluid from patients with multiple sclerosis treated with natalizumab or mitoxantroneQ61699068
Cytoskeleton proteins in CSF distinguish frontotemporal dementia from ADQ73816529
Effects of hemolysis and storage condition on neuron-specific enolase (NSE) in cerebrospinal fluid and serum: implications in clinical practiceQ81366189
Alpha-synuclein in the cerebrospinal fluid differentiates synucleinopathies (Parkinson Disease, dementia with Lewy bodies, multiple system atrophy) from Alzheimer diseaseQ82257191
TREM2 Variants in Alzheimer's DiseaseQ22250873
Variant of TREM2 Associated with the Risk of Alzheimer's DiseaseQ22250874
Amyloid plaque core protein in Alzheimer disease and Down syndromeQ24568384
Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disordersQ26741861
Molecular Pathological Classification of Neurodegenerative Diseases: Turning towards Precision MedicineQ26768648
Neurodegenerative diseases: expanding the prion conceptQ27011744
Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studiesQ27322513
Amyloid precursor protein expression and processing are differentially regulated during cortical neuron differentiationQ27333145
Mammalian occludin in epithelial cells: its expression and subcellular distributionQ28245297
Alzheimer's disease is a synaptic failureQ29547670
Neurofilament Light: A Dynamic Cross-Disease Fluid Biomarker for Neurodegeneration.Q51657545
Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.Q53274559
CSF biomarkers predict a more malignant outcome in Alzheimer disease.Q53309901
Cerebrospinal fluid microglial markers in Alzheimer's disease: elevated chitotriosidase activity but lack of diagnostic utility.Q53319037
Microglial markers are elevated in the prodromal phase of Alzheimer's disease and vascular dementia.Q53331697
Neurogranin in cerebrospinal fluid as a marker of synaptic degeneration in Alzheimer's disease.Q53416640
Alzheimer's diseaseQ29616743
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathologyQ29617284
Clinical and biomarker changes in dominantly inherited Alzheimer's diseaseQ29619940
Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteriaQ30458193
DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's diseaseQ30493811
Intrathecal chemokine levels in Alzheimer disease and frontotemporal lobar degeneration.Q33231194
Intrathecal chemokine synthesis in mild cognitive impairment and Alzheimer diseaseQ33239536
Hyperphosphorylation of tau protein in superficial CNS siderosisQ33350741
The neuropathology of probable Alzheimer disease and mild cognitive impairmentQ33616561
Levels of cerebrospinal fluid α-synuclein oligomers are increased in Parkinson's disease with dementia and dementia with Lewy bodies compared to Alzheimer's diseaseQ33822641
Cerebrospinal fluid and plasma biomarkers in Alzheimer diseaseQ34098866
YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer's diseaseQ34447497
Low CSF levels of both α-synuclein and the α-synuclein cleaving enzyme neurosin in patients with synucleinopathyQ34544824
SNAP-25 is a promising novel cerebrospinal fluid biomarker for synapse degeneration in Alzheimer's diseaseQ34620335
National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's diseaseQ34635272
Cerebrospinal fluid neurofilament light chain protein levels in subtypes of frontotemporal dementiaQ34746995
The diagnostic value of CSF α-synuclein in the differential diagnosis of dementia with Lewy bodies vs. normal subjects and patients with Alzheimer's diseaseQ35055373
TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post-Mortem Temporal CorticesQ35593790
Characterization of the postsynaptic protein neurogranin in paired cerebrospinal fluid and plasma samples from Alzheimer's disease patients and healthy controlsQ35806251
sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markersQ35945633
A panel of nine cerebrospinal fluid biomarkers may identify patients with atypical parkinsonian syndromesQ36045119
CSF neurofilament proteins in the differential diagnosis of dementiaQ36227579
Cerebrospinal fluid neurogranin: relation to cognition and neurodegeneration in Alzheimer's diseaseQ36276592
Neurogranin and YKL-40: independent markers of synaptic degeneration and neuroinflammation in Alzheimer's diseaseQ36402008
Neurogranin as a Cerebrospinal Fluid Biomarker for Synaptic Loss in Symptomatic Alzheimer DiseaseQ36412490
Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer's diseaseQ36454535
Increased CSF neurogranin concentration is specific to Alzheimer diseaseQ36691986
Diagnostic and Prognostic Utility of the Synaptic Marker Neurogranin in Alzheimer DiseaseQ36885492
Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation statusQ36901561
Plasma β-amyloid in Alzheimer's disease and vascular diseaseQ36949501
Plasma tau levels in Alzheimer's diseaseQ36998625
Blood Protein Markers of Neocortical Amyloid-β Burden: A Candidate Study Using SOMAscan TechnologyQ37044150
Prediction of conversion from mild cognitive impairment to dementia with neuronally derived blood exosome protein profileQ37049024
Plasma tau in Alzheimer diseaseQ37384690
Quantification of α-synuclein in cerebrospinal fluid as a biomarker candidate: review of the literature and considerations for future studiesQ37800101
Occludin: one protein, many formsQ37956234
Alzheimer's disease: mimics and chameleons.Q38059197
Amyloid biomarkers in Alzheimer's diseaseQ38404428
Selective vulnerability in neurodegeneration: insights from clinical variants of Alzheimer's diseaseQ38690632
TREM2 Function in Alzheimer's Disease and NeurodegenerationQ38725942
Defeating Alzheimer's disease and other dementias: a priority for European science and societyQ38778638
CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysisQ38805517
Alzheimer's disease cerebrospinal fluid biomarkers predict cognitive decline in lewy body dementiaQ38853776
CSF Aβ1-42 - an excellent but complicated Alzheimer's biomarker - a route to standardisationQ38863280
Review: Tau in biofluids - relation to pathology, imaging and clinical featuresQ39068040
Neurofilaments in blood and CSF for diagnosis and prediction of onset in Creutzfeldt-Jakob diseaseQ39120758
TDP-43 stage, mixed pathologies, and clinical Alzheimer's-type dementiaQ39331146
Hydrodynamic Radii versus Molecular Weights in Clearance Studies of Urine and Cerebrospinal FluidQ39435703
CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survivalQ39469698
Temporal T807 binding correlates with CSF tau and phospho-tau in normal elderlyQ39544835
α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort studyQ39783457
Role of soluble CD14 in cerebrospinal fluid as a regulator of glial functionsQ39861856
Immediate initiation of cART is associated with lower levels of cerebrospinal fluid YKL-40, a marker of microglial activation, in HIV-1 infection.Q40461425
APP metabolism regulates tau proteostasis in human cerebral cortex neuronsQ40660550
Principles of albumin and IgG analyses in neurological disorders. I. Establishment of reference valuesQ40833195
Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2.Q42057034
Cerebrospinal fluid biomarkers in patients with varicella-zoster virus CNS infectionsQ42271966
Association of Cerebrospinal Fluid Neurofilament Light Concentration With Alzheimer Disease ProgressionQ42287644
CNS tau efflux via exosomes is likely increased in Parkinson's disease but not in Alzheimer's diseaseQ42742756
Changes in amyloid-β and Tau in the cerebrospinal fluid of transgenic mice overexpressing amyloid precursor proteinQ43861573
Predicting Alzheimer disease from a blood-based biomarker profile: A 54-month follow-upQ47958225
Phospho-tau/total tau ratio in cerebrospinal fluid discriminates Creutzfeldt-Jakob disease from other dementiasQ48010180
Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia.Q48016761
C-terminal neurogranin is increased in cerebrospinal fluid but unchanged in plasma in Alzheimer's diseaseQ48119991
CSF neurofilament proteins levels are elevated in sporadic Creutzfeldt-Jakob diseaseQ48162267
A New Panel of Blood Biomarkers for the Diagnosis of Mild Traumatic Brain Injury/Concussion in AdultsQ48270426
Development of a Biochemical Diagnosis of Parkinson Disease by Detection of α-Synuclein Misfolded Aggregates in Cerebrospinal FluidQ48405878
CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's diseaseQ48408159
A population study on blood-brain barrier function in 85-year-olds: relation to Alzheimer's disease and vascular dementiaQ48480350
CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findingsQ48559548
Chitinase enzyme activity in CSF is a powerful biomarker of Alzheimer diseaseQ48665932
Cerebrospinal fluid alpha-synuclein in neurodegenerative disorders-a marker of synapse loss?Q48819771
Blood brain barrier function in vascular dementia.Q49026109
Increased CSF α-synuclein levels in Alzheimer's disease: correlation with tau levelsQ49093762
Transient increase in total tau but not phospho-tau in human cerebrospinal fluid after acute strokeQ49117210
Blood-Based Biomarker Candidates of Cerebral Amyloid Using PiB PET in Non-Demented Elderly.Q50221800
CSF tau protein is a useful marker for effective treatment of superficial siderosis of the central nervous system: two case reports.Q50442677
Red blood cells are the major source of alpha-synuclein in blood.Q50663283
Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease.Q50762201
Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or parkinsonian disorders.Q50940972
P433issue1
P921main subjectAlzheimer's diseaseQ11081
biomarkerQ864574
P304page(s)C3-C10
P577publication date2017-04-19
P1433published inAmerican Journal of Physiology - Cell PhysiologyQ2227080
P1476titleApplying fluid biomarkers to Alzheimer's disease
P478volume313