Limited role of free TDP-43 as a diagnostic tool in neurodegenerative diseases

Limited role of free TDP-43 as a diagnostic tool in neurodegenerative diseases is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3109/21678421.2014.905606
P698PubMed publication ID24834468

P50authorMarkus OttoQ67390357
Albert C. LudolphQ67390363
Dietmar R. ThalQ43145446
P2093author name stringPaul Walther
Petra Steinacker
Stefan Lehnert
Anja Schneider
Emily Feneberg
Miriam Linsenmeier
P2860cites workiTRAQ and multiple reaction monitoring as proteomic tools for biomarker search in cerebrospinal fluid of patients with Parkinson's disease dementia.Q54530327
Exosomes: vehicles for the transfer of toxic proteins associated with neurodegenerative diseases?Q21129257
Classification of primary progressive aphasia and its variantsQ24594803
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementiaQ24598142
B lymphocytes secrete antigen-presenting vesiclesQ24678522
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosisQ28131672
Exosomes: from biogenesis and secretion to biological functionQ28270550
Membrane vesicles as conveyors of immune responsesQ29547765
Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteriaQ29614410
TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosisQ29615597
Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73.Q30805170
Cerebrospinal fluid-optimized two-dimensional difference gel electrophoresis (2-D DIGE) facilitates the differential diagnosis of Creutzfeldt-Jakob diseaseQ33371612
Plasma phosphorylated-TDP-43 protein levels correlate with brain pathology in frontotemporal lobar degenerationQ33601762
Frontotemporal lobar degeneration: epidemiology, pathophysiology, diagnosis and managementQ34046590
Protein size and cerebrospinal fluid compositionQ34210609
Identification and proteomic profiling of exosomes in human cerebrospinal fluidQ35744824
TDP-43 protein in plasma may index TDP-43 brain pathology in Alzheimer's disease and frontotemporal lobar degenerationQ36766654
Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease.Q36991962
The role of exosomes in the processing of proteins associated with neurodegenerative diseasesQ37026739
TDP-43 in cerebrospinal fluid of patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosisQ37213414
Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathyQ37681653
TDP-43 and FUS/TLS: cellular functions and implications for neurodegeneration.Q37903416
TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathiesQ37904288
Exosomes: vesicular carriers for intercellular communication in neurodegenerative disordersQ38011636
Cytoplasmic accumulation of TDP-43 in circulating lymphomonocytes of ALS patients with and without TARDBP mutationsQ39811341
Packaging of prions into exosomes is associated with a novel pathway of PrP processing.Q40163902
TDP-43 plasma levels are higher in amyotrophic lateral sclerosisQ47290748
Flow rate of cerebrospinal fluid (CSF)--a concept common to normal blood-CSF barrier function and to dysfunction in neurological diseasesQ48149510
Improved electrophoretic separation and immunoblotting of beta-amyloid (A beta) peptides 1-40, 1-42, and 1-43.Q48772618
Alteration in cell cycle-related proteins in lymphoblasts from carriers of the c.709-1G>A PGRN mutation associated with FTLD-TDP dementia.Q53275555
P433issue5-6
P921main subjectneurodegenerationQ1755122
diagnosisQ16644043
P304page(s)351-356
P577publication date2014-05-16
P1433published inAmyotrophic Lateral Sclerosis and Frontotemporal DegenerationQ23928840
P1476titleLimited role of free TDP-43 as a diagnostic tool in neurodegenerative diseases
P478volume15

Reverse relations

cites work (P2860)
Q93164263An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders
Q57461891Application of bioconjugation chemistry on biosensor fabrication for detection of TAR-DNA binding protein 43
Q39251035Applying fluid biomarkers to Alzheimer's disease
Q89607097Assessment of separation methods for extracellular vesicles from human and mouse brain tissues and human cerebrospinal fluids
Q64079969Biomarkers in Motor Neuron Disease: A State of the Art Review
Q39413097Biomarkers in Neurodegenerative Diseases
Q98613045CSF extracellular vesicle proteomics demonstrates altered protein homeostasis in amyotrophic lateral sclerosis
Q35750755Cerebrospinal Fluid P-Tau181P: Biomarker for Improved Differential Dementia Diagnosis
Q47893862Cerebrospinal Fluid TAR DNA-Binding Protein 43 Combined with Tau Proteins as a Candidate Biomarker for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Spectrum Disorders.
Q36906403Cerebrospinal Fluid TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis Patients with and without the C9ORF72 Hexanucleotide Expansion
Q47587631Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry
Q60310921Current state of Alzheimer's fluid biomarkers
Q58714289Effect of Regulatory Network of Exosomes and microRNAs on Neurodegenerative Diseases
Q38743399Exosome secretion is a key pathway for clearance of pathological TDP-43.
Q39301571Exosomes and their Application in Biomedical Field: Difficulties and Advantages.
Q36577074Exosomes as a Nanodelivery System: a Key to the Future of Neuromedicine?
Q93108989Extracellular RNAs as Biomarkers of Sporadic Amyotrophic Lateral Sclerosis and Other Neurodegenerative Diseases
Q99605512Extracellular Vesicles as Innovative Tool for Diagnosis, Regeneration and Protection against Neurological Damage
Q52309394Extracellular Vesicles: Packages Sent With Complement.
Q38795618Extracellular vesicles and intercellular communication within the nervous system
Q38833377Extracellular vesicles in neurodegenerative disease - pathogenesis to biomarkers.
Q58120685Growth Hormone-Releasing Hormone Administration in Mild Cognitive Impairment and Its Impact on Neuronal Exosome Biomarkers of Dementia
Q51519602Impaired activation of ALS monocytes by exosomes.
Q64113405Leukocyte Derived Microvesicles as Disease Progression Biomarkers in Slow Progressing Amyotrophic Lateral Sclerosis Patients
Q54946040Molecular biomarkers of Alzheimer's disease: progress and prospects.
Q26783410New developments and future opportunities in biomarkers for amyotrophic lateral sclerosis
Q60529524Pathological Proteins Are Transported by Extracellular Vesicles of Sporadic Amyotrophic Lateral Sclerosis Patients
Q39354673Peptidylarginine Deiminases-Roles in Cancer and Neurodegeneration and Possible Avenues for Therapeutic Intervention via Modulation of Exosome and Microvesicle (EMV) Release?
Q89945308Perspectives in fluid biomarkers in neurodegeneration from the 2019 biomarkers in neurodegenerative diseases course-a joint PhD student course at University College London and University of Gothenburg
Q38922025Prion-like propagation as a pathogenic principle in frontotemporal dementia.
Q46285411Progranulin as a candidate biomarker for therapeutic trial in patients with ALS and FTLD.
Q64899263Proteomics Approaches for Biomarker and Drug Target Discovery in ALS and FTD.
Q92310096Recent advances in understanding frontotemporal degeneration
Q58769480Role of Extracellular Vesicles in Amyotrophic Lateral Sclerosis
Q38690632Selective vulnerability in neurodegeneration: insights from clinical variants of Alzheimer's disease
Q55233896Synaptic Failure: Focus in an Integrative View of ALS.
Q35234677TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies
Q55517106TDP-43 as a potential biomarker for amyotrophic lateral sclerosis: a systematic review and meta-analysis.
Q36310560TDP-43 is intercellularly transmitted across axon terminals
Q38529627The Role of TDP-43 in Alzheimer's Disease
Q49823859Towards a TDP-43-Based Biomarker for ALS and FTLD.

Search more.