| P50 | author | Wynand P Roos | Q40011092 |
| | Christian Henninger | Q83253237 |
| P2093 | author name string | Bernd Kaina | |
| | Gerhard Fritz | |
| | Johannes Huelsenbeck | |
| | Anne Schorr | |
| | Stefanie C Huelsenbeck | |
| P2860 | cites work | Pleiotropic effects of statins | Q24647863 |
| | Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses | Q24677973 |
| | Rho GTPases and the actin cytoskeleton | Q27860579 |
| | The DNA damage response: putting checkpoints in perspective | Q28131713 |
| | DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139 | Q28131715 |
| | p21-activated protein kinase gamma-PAK is activated by ionizing radiation and other DNA-damaging agents. Similarities and differences to alpha-PAK | Q28146019 |
| | DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation | Q28206029 |
| | The DNA damage response: ten years after | Q28261230 |
| | Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA | Q28267082 |
| | NBS1 and its functional role in the DNA damage response | Q28274249 |
| | An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase | Q28276857 |
| | Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs | Q29547308 |
| | Rho GTPases and their effector proteins | Q29547740 |
| | Rational design and characterization of a Rac GTPase-specific small molecule inhibitor | Q29616494 |
| | Lovastatin potentiates antitumor activity and attenuates cardiotoxicity of doxorubicin in three tumor models in mice. | Q31379760 |
| | Etoposide targets topoisomerase IIalpha and IIbeta in leukemic cells: isoform-specific cleavable complexes visualized and quantified in situ by a novel immunofluorescence technique | Q32055762 |
| | A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin | Q33540751 |
| | A minority of foci or pan-nuclear apoptotic staining of gammaH2AX in the S phase after UV damage contain DNA double-strand breaks | Q33859669 |
| | Anthracycline-induced clinical heart failure in a cohort of 607 children: long-term follow-up study. | Q33929555 |
| | Nox2 NADPH oxidase promotes pathologic cardiac remodeling associated with Doxorubicin chemotherapy | Q34322162 |
| | ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks | Q34722732 |
| | H2AX phosphorylation within the G1 phase after UV irradiation depends on nucleotide excision repair and not DNA double-strand breaks | Q34772965 |
| | DNA topoisomerases in cancer chemotherapy: using enzymes to generate selective DNA damage | Q34996522 |
| | Apoptosis induced by topoisomerase inhibitors | Q35137789 |
| | The role of nitric oxide in anthracycline toxicity and prospects for pharmacologic prevention of cardiac damage | Q35726086 |
| | Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies. | Q35865072 |
| | Lovastatin protects human endothelial cells from the genotoxic and cytotoxic effects of the anticancer drugs doxorubicin and etoposide | Q36054324 |
| | Toxicity of the topoisomerase II inhibitors | Q36081997 |
| | DNA damage-induced cell death by apoptosis. | Q36561337 |
| | Radiation-induced DNA damage responses | Q36757164 |
| | Supreme EnLIGHTenment: damage recognition and signaling in the mammalian UV response | Q37086576 |
| | Pleiotropic effects of statins. - Basic research and clinical perspectives -. | Q37252114 |
| | Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin | Q37261069 |
| | Anthracycline-induced cardiotoxicity: overview of studies examining the roles of oxidative stress and free cellular iron | Q37421187 |
| | Targeting the mevalonate pathway for improved anticancer therapy | Q37512308 |
| | Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity. | Q38576068 |
| | Genotoxicity of dietary, environmental and therapeutic topoisomerase II poisons is uniformly correlated to prolongation of enzyme DNA residence | Q39552708 |
| | Tiam1-Rac signaling counteracts Eg5 during bipolar spindle assembly to facilitate chromosome congression | Q39722145 |
| | The nuclear import of the small GTPase Rac1 is mediated by the direct interaction with karyopherin alpha2. | Q39766901 |
| | Topoisomerase II{alpha}-dependent and -independent apoptotic effects of dexrazoxane and doxorubicin | Q39856397 |
| | Successful mitigation of delayed intestinal radiation injury using pravastatin is not associated with acute injury improvement or tumor protection | Q40098414 |
| | ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation | Q40570996 |
| | Doxorubicin paradoxically protects cardiomyocytes against iron-mediated toxicity: role of reactive oxygen species and ferritin | Q40596497 |
| | Rac1 regulates interleukin 1-induced nuclear factor kappaB activation in an inhibitory protein kappaBalpha-independent manner by enhancing the ability of the p65 subunit to transactivate gene expression | Q40903259 |
| | Signaling from G protein-coupled receptors to c-Jun kinase involves beta gamma subunits of heterotrimeric G proteins acting on a Ras and Rac1-dependent pathway | Q41226993 |
| | Anthracyclines in the treatment of cancer. An overview | Q41637134 |
| | Statins use a novel Nijmegen breakage syndrome-1-dependent pathway to accelerate DNA repair in vascular smooth muscle cells | Q42440684 |
| | Three distinct signalling responses by murine fibroblasts to genotoxic stress | Q42807014 |
| | Chronic doxorubicin cardiotoxicity is mediated by oxidative DNA damage-ATM-p53-apoptosis pathway and attenuated by pitavastatin through the inhibition of Rac1 activity | Q43297511 |
| | The activation of c-Jun NH2-terminal kinase (JNK) by DNA-damaging agents serves to promote drug resistance via activating transcription factor 2 (ATF2)-dependent enhanced DNA repair | Q44381511 |
| | Pretreatment with statin attenuates the cardiotoxicity of Doxorubicin in mice | Q46160813 |
| | Importance of Rac1 signaling pathway inhibition in the pleiotropic effects of HMG-CoA reductase inhibitors | Q46211676 |
| | Lovastatin protects human endothelial cells from killing by ionizing radiation without impairing induction and repair of DNA double-strand breaks | Q46934975 |
| | Chromosomal damage and atherosclerosis. A protective effect from simvastatin | Q46948512 |
| | Eukaryotic DNA topoisomerase II beta | Q47958229 |
| | Topoisomerase II function detected as protein-DNA complexes in two sublines of HL-60 cells. | Q54244046 |
| | Serine 1524 is a major site of phosphorylation on human topoisomerase II alpha protein in vivo and is a substrate for casein kinase II in vitro. | Q54623679 |
| | p21-activated Protein Kinase γ-PAK Is Activated by Ionizing Radiation and Other DNA-damaging Agents | Q56866585 |
| | Three paths to stress relief | Q59054090 |
| | Topoisomerase IIbeta mediated DNA double-strand breaks: implications in doxorubicin cardiotoxicity and prevention by dexrazoxane | Q64387817 |
| | The comet assay: a method to measure DNA damage in individual cells | Q64388028 |
| | Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I | Q70915257 |
| | Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153 | Q73617992 |
| | Clinical heart failure in a cohort of children treated with anthracyclines: a long-term follow-up study | Q80304240 |
| | Anthracycline-induced cardiotoxicity | Q82298914 |
| P433 | issue | 46 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | DNA damage | Q5205747 |
| P304 | page(s) | 38590-38599 | |
| P577 | publication date | 2012-09-25 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Rac1 protein signaling is required for DNA damage response stimulated by topoisomerase II poisons | |
| P478 | volume | 287 | |