Calcineurin in reactive astrocytes plays a key role in the interplay between proinflammatory and anti-inflammatory signals

scientific article

Calcineurin in reactive astrocytes plays a key role in the interplay between proinflammatory and anti-inflammatory signals is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1523/JNEUROSCI.1002-07.2007
P8608Fatcat IDrelease_psk3lluvofhrln3oupxu42766e
P932PMC publication ID6672188
P698PubMed publication ID17699657
P5875ResearchGate publication ID6139389

P50authorIgnacio Torres AlemanQ43179267
P2093author name stringAna M Fernandez
Miguel Garcia-Garcia
Paloma Carrero
Silvia Fernandez
P2860cites workCalcineurin-GATA-6 pathway is involved in smooth muscle-specific transcriptionQ24292438
Human CD14 mediates recognition and phagocytosis of apoptotic cellsQ24336506
DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathwaysQ28138804
Transcription factors of the NFAT family: regulation and functionQ28237645
Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophagesQ28283333
Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetesQ28345343
Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesisQ28505151
Developmental regulation of the mouse IGF-I exon 1 promoter region by calcineurin activation of NFAT in skeletal muscleQ28508516
Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosisQ28592161
Circulating insulin-like growth factor I mediates exercise-induced increases in the number of new neurons in the adult hippocampus.Q32062012
Association of calcineurin with mitochondrial proteinsQ33241148
Reactive microgliosisQ33604483
Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's modelsQ33947378
Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgammaQ34249625
Serum growth factors and neuroprotective surveillance: focus on IGF-1.Q34265977
Glia and their cytokines in progression of neurodegenerationQ34382722
Phosphatases: counterregulatory role in inflammatory cell signalingQ34487892
Inflammation in neurodegenerative disease--a double-edged swordQ34775762
Neuro-inflammation as a therapeutic target in amyotrophic lateral sclerosis.Q35045218
The impact of systemic infection on the progression of neurodegenerative disease.Q35058498
Astrocyte apoptosis: implications for neuroprotectionQ35737824
Molecular mechanisms of neuroprotective action of immunosuppressants--facts and hypotheses.Q35748218
Insulin-like growth factor I restores motor coordination in a rat model of cerebellar ataxiaQ35802448
Role of inflammation in neurodegenerative diseasesQ36125754
Mitochondria to nucleus stress signaling: a distinctive mechanism of NFkappaB/Rel activation through calcineurin-mediated inactivation of IkappaBbetaQ36323494
Astrocyte dysfunction in neurological disorders: a molecular perspectiveQ36404127
Insulin-like growth factor I is required for vessel remodeling in the adult brainQ36449180
Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-alpha/nuclear factor-kappaB (NF-kappaB)-inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop.Q40615729
Coordination of three signaling enzymes by AKAP79, a mammalian scaffold proteinQ41216893
FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurinQ41618754
Reactive astrocytes: cellular and molecular cues to biological functionQ41673434
Oxidative inactivation of calcineurin by Cu,Zn superoxide dismutase G93A, a mutant typical of familial amyotrophic lateral sclerosis.Q43794664
NFAT4 is expressed in primary astrocytes and activated by glutamateQ44387885
Transcriptional regulation of IGF-I expression in skeletal muscleQ44963948
Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS MiceQ46254778
'PPAR'ting ways with inflammation.Q46715539
Glia as a therapeutic target: selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration.Q46890625
Protein kinase-mediated regulation of calcineurin through the phosphorylation of modulatory calcineurin-interacting protein 1.Q46895776
The LPS receptor (CD14) links innate immunity with Alzheimer's diseaseQ47405789
Co-ordinated and cellular specific induction of the components of the IGF/IGFBP axis in the rat brain following hypoxic-ischemic injuryQ48399935
Generation of constitutively active calcineurin by calpain contributes to delayed neuronal death following mouse brain ischemiaQ48485570
Insulin-like growth factor I modulates c-Fos induction and astrocytosis in response to neurotoxic insultQ48825477
Inflammation and primary demyelination induced by the intraspinal injection of lipopolysaccharide.Q48901120
Reduction of calcineurin enzymatic activity in Alzheimer's disease: correlation with neuropathologic changesQ48958065
T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genesQ50111962
beta-amyloid peptides are cytotoxic to astrocytes in culture: a role for oxidative stress.Q53342702
Free insulin-like growth factor (IGF)-I and IGF binding proteins 2, 5, and 6 in spinal motor neurons in amyotrophic lateral sclerosisQ73179770
Insulin-like growth factor-I stimulates dephosphorylation of ikappa B through the serine phosphatase calcineurin (protein phosphatase 2B)Q74270283
Expression of tumor necrosis factor alpha (TNFalpha) following transient cerebral ischemiaQ75372373
TNF-alpha-induced tolerance to ischemic injury involves differential control of NF-kappaB transactivation: the role of NF-kappaB association with p300 adaptorQ77584948
Distinctive calcineurin-dependent (FK506-sensitive) mechanisms regulate the production of the CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES vs IL-2 and TNF-alpha by activated human T cellsQ77759726
Blockade of NFAT activation by the second calcineurin binding siteQ82238797
A global analysis of cross-talk in a mammalian cellular signalling networkQ83339233
P433issue33
P407language of work or nameEnglishQ1860
P921main subjectinflammationQ101991
astrocyteQ502961
P304page(s)8745-8756
P577publication date2007-08-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleCalcineurin in reactive astrocytes plays a key role in the interplay between proinflammatory and anti-inflammatory signals
P478volume27

Reverse relations

cites work (P2860)
Q39093102A phosphatase-independent gain-of-function mutation in PTEN triggers aberrant cell growth in astrocytes through an autocrine IGF-1 loop.
Q93205779Astrocytes: Heterogeneous and Dynamic Phenotypes in Neurodegeneration and Innate Immunity
Q48176684Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice
Q35846785Astroglial NF-κB mediates oxidative stress by regulation of NADPH oxidase in a model of retinal ischemia reperfusion injury.
Q47547973Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes
Q92006668Axonal Protection by Tacrolimus with Inhibition of NFATc1 in TNF-Induced Optic Nerve Degeneration
Q36534321Blockade of Astrocytic Calcineurin/NFAT Signaling Helps to Normalize Hippocampal Synaptic Function and Plasticity in a Rat Model of Traumatic Brain Injury.
Q38881070Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-β-Induced Neuronal Death.
Q90429677Ca2+, Astrocyte Activation and Calcineurin/NFAT Signaling in Age-Related Neurodegenerative Diseases
Q49189820Calcineurin A beta deficiency ameliorates HFD-induced hypothalamic astrocytosis in mice
Q90632253Calcineurin Controls Expression of EAAT1/GLAST in Mouse and Human Cultured Astrocytes through Dynamic Regulation of Protein Synthesis and Degradation
Q34234080Calcineurin and glial signaling: neuroinflammation and beyond
Q47844226Calcineurin phosphatase as a negative regulator of fear memory in hippocampus: control on nuclear factor-κB signaling in consolidation and reconsolidation
Q40741759Calcineurin proteolysis in astrocytes: Implications for impaired synaptic function
Q39128188Calcineurin regulates nuclear factor I dephosphorylation and activity in malignant glioma cell lines
Q39661848Calcineurin β protects brain after injury by activating the unfolded protein response
Q40179990Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in Aβ-Bearing Mice
Q38113356Calcium dysregulation and neuroinflammation: discrete and integrated mechanisms for age-related synaptic dysfunction
Q40009971Calcium/calcineurin signaling in primary cortical astrocyte cultures: Rcan1-4 and cyclooxygenase-2 as NFAT target genes.
Q37434914Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling.
Q59049611Cytokine Serum Levels as Potential Biological Markers for the Psychopathology in Schizophrenia
Q50546416Deleting IGF-1 receptor from forebrain neurons confers neuroprotection during stroke and upregulates endocrine somatotropin.
Q39495638Differential effect of traumatic brain injury on the nuclear factor of activated T Cells C3 and C4 isoforms in the rat hippocampus
Q33624793Disparate effects of serum on basal and evoked NFAT activity in primary astrocyte cultures
Q26797399Elusive roles for reactive astrocytes in neurodegenerative diseases
Q43866256Expression and activities of N-myristoyltransferase and calcineurin in normal and inflamed lungs
Q36541898Frataxin deficiency unveils cell-context dependent actions of insulin-like growth factor I on neurons
Q38094638Generating new neurons to circumvent your fears: the role of IGF signaling.
Q28577238Inhibition of soluble tumor necrosis factor ameliorates synaptic alterations and Ca2+ dysregulation in aged rats
Q36808464Interleukin-1beta-dependent signaling between astrocytes and neurons depends critically on astrocytic calcineurin/NFAT activity.
Q64969921Intracellular Ca2+ Increases and Connexin 43 Hemichannel Opening Are Necessary but Not Sufficient for Thy-1-Induced Astrocyte Migration.
Q54688691Involvement of SRC-suppressed C kinase substrate in neuronal death caused by the lipopolysaccharide-induced reactive astrogliosis.
Q46620286Mechanical lesion activates newly identified NFATc1 in primary astrocytes: implication of ATP and purinergic receptors.
Q35682349Mechanisms of dendritic spine remodeling in a rat model of traumatic brain injury
Q36654889Modulation of inflammatory cytokines and mitogen-activated protein kinases by acetate in primary astrocytes
Q51033680NFATc3 promotes Ca(2+) -dependent MMP3 expression in astroglial cells.
Q40060551NFATs and Alzheimer's Disease.
Q42735129Protein phosphatase 2B (PP2B, calcineurin) in Paramecium: partial characterization reveals that two members of the unusually large catalytic subunit family have distinct roles in calcium-dependent processes
Q47263918Psychiatric polygenic risk associates with cortical morphology and functional organization in aging
Q38017625Reactive astrogliosis after spinal cord injury-beneficial and detrimental effects.
Q48832254Regulation of the phosphatase calcineurin by insulin-like growth factor I unveils a key role of astrocytes in Alzheimer's pathology.
Q42547344Regulator of calcineurin 1 (Rcan1) has a protective role in brain ischemia/reperfusion injury
Q54405372Response of transcription factor NFATc3 to excitotoxic and traumatic brain insults: identification of a subpopulation of reactive astrocytes.
Q27303152Role of transient receptor potential ankyrin 1 channels in Alzheimer's disease
Q42289447Signaling pathways implicated in the stimulation of beta-cell proliferation by extracellular matrix
Q37302851Targeted activation of astrocytes: a potential neuroprotective strategy.
Q42352469Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease.
Q37004725Targeting insulin-like growth factor-1 to treat Alzheimer's disease
Q28067014The Emerging Roles of the Calcineurin-Nuclear Factor of Activated T-Lymphocytes Pathway in Nervous System Functions and Diseases
Q38123243The impact of neuroimmune changes on development of amyloid pathology; relevance to Alzheimer's disease.
Q48601088The insulin-like growth factor I receptor regulates glucose transport by astrocytes.
Q37994953The many faces of insulin-like peptide signalling in the brain
Q36348658The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease
Q37784863The roles of TNF in brain dysfunction and disease
Q26775092Therapeutic Targets for Neurodevelopmental Disorders Emerging from Animal Models with Perinatal Immune Activation
Q86512637Traumatic Brain Injury Causes a Tacrolimus-Sensitive Increase in Non-Convulsive Seizures in a Rat Model of Post-Traumatic Epilepsy
Q37115203Ulinastatin attenuates neuropathic pain induced by L5-VRT via the calcineurin/IL-10 pathway.
Q49884884Understanding Progressive Multifocal Leukoencephalopathy Risk in Multiple Sclerosis Patients Treated with Immunomodulatory Therapies: A Bird's Eye View
Q48713451Variation in PPP3CC Genotype Is Associated with Long-Term Recovery after Severe Brain Injury.