Sub1/PC4, a multifaceted factor: from transcription to genome stability

scientific article published on 31 May 2017

Sub1/PC4, a multifaceted factor: from transcription to genome stability is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/S00294-017-0715-6
P698PubMed publication ID28567479

P50authorMiguel GaravísQ59662239
Olga CalvoQ61937922
P2093author name stringMiguel Garavís
Olga Calvo
P2860cites workEvolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and terminationQ24291290
Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genesQ24317228
Highly prevalent putative quadruplex sequence motifs in human DNAQ24529050
Prevalence of quadruplexes in the human genomeQ24529051
FCP1, a phosphatase specific for the heptapeptide repeat of the largest subunit of RNA polymerase II, stimulates transcription elongationQ24540277
Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co-activator PC4Q24563103
A protein phosphatase functions to recycle RNA polymerase IIQ24602725
General transcriptional coactivator PC4 activates p53 functionQ24607528
A dynamic model for PC4 coactivator function in RNA polymerase II transcriptionQ24685747
G-quadruplexes and helicasesQ26765428
G-quadruplexes and their regulatory roles in biologyQ26782619
The RNA polymerase II carboxy-terminal domain (CTD) codeQ27023990
Structure of an RNA polymerase II preinitiation complexQ27318217
Architecture of initiation-competent 12-subunit RNA polymerase IIQ27641248
Complete, 12-subunit RNA polymerase II at 4.1-Å resolution: Implications for the initiation of transcriptionQ27641250
Architecture of the RNA polymerase-Spt4/5 complex and basis of universal transcription processivityQ27667221
Structural features of the single-stranded DNA-binding protein MoSub1 from Magnaporthe oryzaeQ27682127
Mediator subunits and histone methyltransferase Set2 contribute to Ino2-dependent transcriptional activation of phospholipid biosynthesis in the yeast Saccharomyces cerevisiaeQ43200898
Structure and mechanism of RNA polymerase II CTD phosphatasesQ45013588
Phosphorylation of RNA polymerase IIA occurs subsequent to interaction with the promoter and before the initiation of transcriptionQ46409988
RNA emerging from the active site of RNA polymerase II interacts with the Rpb7 subunitQ46835516
ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner.Q47407852
Functional redundancy and structural polymorphism in the large subunit of RNA polymerase II.Q48338515
Transcriptional repression of the IMD2 gene mediated by the transcriptional co-activator Sub1.Q52589471
Telomerase recruitment by the telomere end binding protein-beta facilitates G-quadruplex DNA unfolding in ciliates.Q53476593
High-affinity DNA binding by the C-terminal domain of the transcriptional coactivator PC4 requires simultaneous interaction with two opposing unpaired strands and results in helix destabilization.Q53957832
The CTD code.Q53963724
RPB7, one of two dissociable subunits of yeast RNA polymerase II, is essential for cell viabilityQ57412417
Human transcriptional coactivator PC4 stimulates DNA end joining and activates DSB repair activityQ64387468
A transcriptional autoregulatory loop for KIN28-CCL1 and SRB10-SRB11, each encoding RNA polymerase II CTD kinase-cyclin pair, stimulates the meiotic development of S. cerevisiaeQ73912055
A universal RNA polymerase II CTD cycle is orchestrated by complex interplays between kinase, phosphatase, and isomerase enzymes along genesQ83344227
Potential G-quadruplex formation at breakpoint regions of chromosomal translocations in cancer may explain their fragilityQ84279386
Phosphorylation of the transcription elongation factor Spt5 by yeast Bur1 kinase stimulates recruitment of the PAF complex.Q37302219
How eukaryotic genes are transcribedQ37514183
Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cellsQ37606074
The nonphosphorylated form of RNA polymerase II preferentially associates with the preinitiation complexQ37617641
Transcript Elongation by RNA Polymerase II.Q37724162
Cycling through transcription with the RNA polymerase F/E (RPB4/7) complex: structure, function and evolution of archaeal RNA polymeraseQ37791674
Evolution of multisubunit RNA polymerases in the three domains of life.Q37828367
Archaeal RNA polymerase and transcription regulation.Q37830691
Tails of RNA polymerase II.Q38003896
Rpb4 and Rpb7: multifunctional subunits of RNA polymerase II.Q38037139
Dynamic phosphorylation patterns of RNA polymerase II CTD during transcriptionQ38043848
The impact of transcription on posttranscriptional processes in yeastQ38103740
The writers, readers, and functions of the RNA polymerase II C-terminal domain codeQ38120305
A global transcription cofactor bound to juxtaposed strands of unwound DNA.Q38316757
Identification of the single-stranded DNA binding surface of the transcriptional coactivator PC4 by NMR.Q38328995
Mediator Architecture and RNA Polymerase II Interaction.Q38724799
RNA G-quadruplexes: emerging mechanisms in diseaseQ38778353
The importance of controlling mRNA turnover during cell proliferationQ38786055
A biochemical and biophysical model of G-quadruplex DNA recognition by positive coactivator of transcription 4.Q38833611
The pol II CTD: new twists in the tailQ38948938
G-Quadruplexes in DNA Replication: A Problem or a Necessity?Q38963148
Function and control of RNA polymerase II C-terminal domain phosphorylation in vertebrate transcription and RNA processingQ39002232
DNA G-quadruplexes in the human genome: detection, functions and therapeutic potentialQ39146404
The code and beyond: transcription regulation by the RNA polymerase II carboxy-terminal domainQ39156173
p53 regulates its own activator: transcriptional co-activator PC4, a new p53-responsive geneQ39253152
RNAP II CTD phosphorylated on threonine-4 is required for histone mRNA 3' end processingQ39448117
Hot1 factor recruits co-activator Sub1 and elongation complex Spt4/5 to osmostress genesQ39537298
The RNA Pol II CTD phosphatase Fcp1 is essential for normal development in Drosophila melanogasterQ39820730
Direct Analysis of Phosphorylation Sites on the Rpb1 C-Terminal Domain of RNA Polymerase II.Q40073291
Activation of p53 function by human transcriptional coactivator PC4: role of protein-protein interaction, DNA bending, and posttranslational modificationsQ40085549
Multifunctional human transcriptional coactivator protein PC4 is a substrate of Aurora kinases and activates the Aurora enzymesQ40097443
Human PC4 is a substrate-specific inhibitor of RNA polymerase II phosphorylationQ40897870
Properties of PC4 and an RNA polymerase II complex in directing activated and basal transcription in vitroQ41032848
The Sub1 nuclear protein protects DNA from oxidative damageQ41465301
DNA replication through G-quadruplex motifs is promoted by the Saccharomyces cerevisiae Pif1 DNA helicaseQ41769196
Interaction of PC4 with melted DNA inhibits transcriptionQ41791540
From structure to systems: high-resolution, quantitative genetic analysis of RNA polymerase II.Q41882250
Sub1 globally regulates RNA polymerase II C-terminal domain phosphorylation.Q42107719
Transcription cofactor PC4 plays essential roles in collaboration with the small subunit of general transcription factor TFIIE.Q42467028
A yeast transcriptional stimulatory protein similar to human PC4.Q42519847
Human positive coactivator 4 controls heterochromatinization and silencing of neural gene expression by interacting with REST/NRSF and CoREST.Q43192179
Rtr1 Is a Dual Specificity Phosphatase That Dephosphorylates Tyr1 and Ser5 on the RNA Polymerase II CTDQ27684418
Bacteriophage T5 encodes a homolog of the eukaryotic transcription coactivator PC4 implicated in recombination-dependent DNA replicationQ27685493
Architecture of the RNA polymerase II-Mediator core initiation complexQ27697899
Structural analysis and knock-out of a Burkholderia pseudomallei homolog of the eukaryotic transcription coactivator PC4Q27702909
Structure of a Complete Mediator-RNA Polymerase II Pre-Initiation ComplexQ27728022
C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding siteQ27747056
The transcriptional coactivator PC4/Sub1 has multiple functions in RNA polymerase II transcription.Q27930005
RNA polymerase II termination involves C-terminal-domain tyrosine dephosphorylation by CPF subunit Glc7Q27932489
Pif1 family helicases suppress genome instability at G-quadruplex motifsQ27932667
Sub1 functions in osmoregulation and in transcription by both RNA polymerases II and IIIQ27933559
The Rpb4 subunit of RNA polymerase II contributes to cotranscriptional recruitment of 3' processing factorsQ27934138
Mediator head module structure and functional interactionsQ27934655
Genome-wide location analysis reveals a role of TFIIS in RNA polymerase III transcriptionQ27935493
Structures of complete RNA polymerase II and its subcomplex, Rpb4/7.Q27935627
A motif shared by TFIIF and TFIIB mediates their interaction with the RNA polymerase II carboxy-terminal domain phosphatase Fcp1p in Saccharomyces cerevisiaeQ27936438
Ssu72 phosphatase-dependent erasure of phospho-Ser7 marks on the RNA polymerase II C-terminal domain is essential for viability and transcription termination.Q27936613
Ssu72 Is an RNA polymerase II CTD phosphataseQ27936648
Mediator-dependent recruitment of TFIIH modules in preinitiation complexQ27939036
Genome-wide location analysis reveals a role for Sub1 in RNA polymerase III transcriptionQ27939629
Differential requirement for SUB1 in chromosomal and plasmid double-strand DNA break repairQ27939893
Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcriptionQ28131686
TFIIH is negatively regulated by cdk8-containing mediator complexesQ28138931
In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronucleiQ28204801
Alleviation of PC4-mediated transcriptional repression by the ERCC3 helicase activity of general transcription factor TFIIHQ28210006
The transcription cycle in eukaryotes: from productive initiation to RNA polymerase II recyclingQ28258983
Re-evaluation of G-quadruplex propensity with G4HunterQ28272354
DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase IIIQ28276224
Structure of eukaryotic RNA polymerasesQ28284822
Quantitative visualization of DNA G-quadruplex structures in human cellsQ28285848
Opposing effects of Ctk1 kinase and Fcp1 phosphatase at Ser 2 of the RNA polymerase II C-terminal domainQ28343959
Disruption of Transcriptional Coactivator Sub1 Leads to Genome-Wide Re-distribution of Clustered Mutations Induced by APOBEC in Active Yeast GenesQ28547015
Sub1 associates with Spt5 and influences RNA polymerase II transcription elongation rateQ28714380
RNA Polymerase II C-Terminal Domain: Tethering Transcription to Transcript and TemplateQ29540749
Evidence of the involvement of O-GlcNAc-modified human RNA polymerase II CTD in transcription in vitro and in vivoQ36078777
Quadruplex formation by both G-rich and C-rich DNA strands of the C9orf72 (GGGGCC)8•(GGCCCC)8 repeat: effect of CpG methylationQ36676565
The single-strand DNA binding activity of human PC4 prevents mutagenesis and killing by oxidative DNA damageQ36731755
RNA polymerase II subunit RPB4 is essential for high- and low-temperature yeast cell growthQ36769195
The positions of TFIIF and TFIIE in the RNA polymerase II transcription preinitiation complex.Q36791306
Transcription-positive cofactor 4 forms complexes with HSSB (RPA) on single-stranded DNA and influences HSSB-dependent enzymatic synthesis of simian virus 40 DNA.Q36807289
Tetraplex DNA and its interacting proteinsQ36813999
Mapping RNA exit channel on transcribing RNA polymerase II by FRET analysisQ37028678
DNA damage and repair: from molecular mechanisms to health implications.Q37060426
Translocation and deletion breakpoints in cancer genomes are associated with potential non-B DNA-forming sequencesQ37076289
The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivoQ37168915
The C-terminal domain of RNA polymerase II is modified by site-specific methylationQ37171230
Phosphorylation of serine 2 within the RNA polymerase II C-terminal domain couples transcription and 3' end processingQ29614768
RNA polymerase II and the integration of nuclear eventsQ29614772
Progression through the RNA polymerase II CTD cycleQ29614782
Extensive homology among the largest subunits of eukaryotic and prokaryotic RNA polymerasesQ29617053
Functions of single-strand DNA-binding proteins in DNA replication, recombination, and repairQ30155229
Mutational analysis of yeast TFIIB. A functional relationship between Ssu72 and Sub1/Tsp1 defined by allele-specific interactions with TFIIB.Q30785966
Recruitment of RNA polymerase II cofactor PC4 to DNA damage sitesQ33388647
Eukaryotic single-stranded DNA binding proteins: central factors in genome stability.Q33518639
Sub1 contacts the RNA polymerase II stalk to modulate mRNA synthesis.Q33557757
The Ess1 prolyl isomerase: traffic cop of the RNA polymerase II transcription cycleQ33726010
Yeast Sub1 and human PC4 are G-quadruplex binding proteins that suppress genome instability at co-transcriptionally formed G4 DNAQ33741063
Insights into how Spt5 functions in transcription elongation and repressing transcription coupled DNA repairQ33791149
Sub1 and RPA associate with RNA polymerase II at different stages of transcriptionQ34067654
Formation of a carboxy-terminal domain phosphatase (Fcp1)/TFIIF/RNA polymerase II (pol II) complex in Schizosaccharomyces pombe involves direct interaction between Fcp1 and the Rpb4 subunit of pol IIQ34302645
DNA and RNA quadruplex-binding proteinsQ34486584
Gradual phosphorylation regulates PC4 coactivator functionQ34524536
Multisubunit RNA polymerasesQ34525904
The general transcription machinery and general cofactorsQ34549899
The Ssu72 phosphatase mediates the RNA polymerase II initiation-elongation transitionQ34634152
Rpb4/7 facilitates RNA polymerase II CTD dephosphorylationQ34712027
The cyclin-dependent kinase 8 module sterically blocks Mediator interactions with RNA polymerase II.Q35127464
Transcriptional coactivator PC4, a chromatin-associated protein, induces chromatin condensationQ35131476
Strange bedfellows: polyadenylation factors at the promoterQ35143449
Sub1 and Maf1, two effectors of RNA polymerase III, are involved in the yeast quiescence cycleQ35532169
Transcriptional regulation in Saccharomyces cerevisiae: transcription factor regulation and function, mechanisms of initiation, and roles of activators and coactivators.Q35542072
PC4 promotes genome stability and DNA repair through binding of ssDNA at DNA damage sitesQ35626876
Yeast transcription co-activator Sub1 and its human homolog PC4 preferentially bind to G-quadruplex DNA.Q35735600
RNA polymerase II structure: from core to functional complexesQ35804643
The spt5 C-terminal region recruits yeast 3' RNA cleavage factor I.Q35826689
Heptad-Specific Phosphorylation of RNA Polymerase II CTD.Q35901477
Rpb4 and Rpb7: subunits of RNA polymerase II and beyondQ35950705
Proteome-wide identification of in vivo targets of DNA damage checkpoint kinasesQ35973264
G4-associated human diseasesQ36004245
Replication protein A and more: single-stranded DNA-binding proteins in eukaryotic cellsQ36010274
Human single-stranded DNA binding proteins: guardians of genome stabilityQ36027589
P433issue6
P921main subjectgenome stabilityQ98655700
P304page(s)1023-1035
P577publication date2017-05-31
P1433published inCurrent GeneticsQ15765847
P1476titleSub1/PC4, a multifaceted factor: from transcription to genome stability
P478volume63

Reverse relations

cites work (P2860)
Q91994051Chromatin protein PC4 is downregulated in breast cancer to promote disease progression: Implications of miR-29a
Q94564659PC4 serves as a negative regulator of skin wound healing in mice
Q64087620The human positive cofactor 4 promotes androgen-independent prostate cancer development and progression through HIF-1α/β-catenin pathway
Q64107537Transcriptional positive cofactor 4 promotes breast cancer proliferation and metastasis through c-Myc mediated Warburg effect

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