PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca(2+) uptake in immortalized cells

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PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca(2+) uptake in immortalized cells is …
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scholarly articleQ13442814

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P819ADS bibcode2016NatCo...712897M
P6179Dimensions Publication ID1038813567
P356DOI10.1038/NCOMMS12897
P932PMC publication ID5031806
P698PubMed publication ID27642082

P50authorRoland MalliQ39636421
Wolfgang GraierQ39636454
Benjamin GottschalkQ57078902
Tobias MadlQ62642451
Markus Waldeck-WeiermairQ63887126
Christiane KlecQ63991549
Emrah ErogluQ92709613
Alexander I BondarenkoQ95360884
Corina T Madreiter-SokolowskiQ42290269
P2093author name stringNicole A Hofmann
Rene Rost
Sarah Stryeck
Warisara Parichatikanond
Sergio Pulido
P2860cites workMICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptakeQ24294670
MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survivalQ24301822
MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolismQ24304898
Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporterQ24306825
A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporterQ24306850
Suppression of receptor interacting protein 140 repressive activity by protein arginine methylationQ24307788
PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase familyQ24310851
Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptakeQ24336668
MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activityQ24338031
EMRE is an essential component of the mitochondrial calcium uniporter complexQ24339589
Arginine methyltransferases as novel therapeutic targets for breast cancerQ26851594
Loss of UCP2 attenuates mitochondrial dysfunction without altering ROS production and uncoupling activityQ27315724
Structure of the Predominant Protein Arginine Methyltransferase PRMT1 and Analysis of Its Binding to Substrate PeptidesQ27641186
Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteinsQ27675678
The elusive importance of being a mitochondrial Ca(2+) uniporterQ38196135
The mitochondrial Ca(2+) uniporter complexQ38281070
Non-histone protein methylation as a regulator of cellular signalling and functionQ38285792
Molecular mechanism of mitochondrial calcium uptakeQ38303689
The molecular era of the mitochondrial calcium uniporterQ38569106
Uncoupling protein 3 adjusts mitochondrial Ca(2+) uptake to high and low Ca(2+) signalsQ39636248
Possible involvement of mitochondrial uncoupling protein-2 in cytotoxicity mediated by acquired N-methyl-D-aspartate receptor channels.Q52624101
The contribution of UCP2 and UCP3 to mitochondrial Ca(2+) uptake is differentially determined by the source of supplied Ca(2+)Q84077364
Molecular control of mitochondrial calcium uptakeQ87801950
The uniporter: from newly identified parts to functionQ87846624
Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancersQ39703295
Ca2+ hot spots on the mitochondrial surface are generated by Ca2+ mobilization from stores, but not by activation of store-operated Ca2+ channels.Q39711158
Analysis of the structure and function of EMRE in a yeast expression systemQ39899817
Molecularly distinct routes of mitochondrial Ca2+ uptake are activated depending on the activity of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA)Q41019557
Regulation of retinal dehydrogenases and retinoic acid synthesis by cholesterol metabolitesQ41457470
UCP2 inhibition sensitizes breast cancer cells to therapeutic agents by increasing oxidative stressQ41748758
EMRE Is a Matrix Ca(2+) Sensor that Governs Gatekeeping of the Mitochondrial Ca(2+) Uniporter.Q41889367
MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporterQ41976396
Rearrangement of MICU1 multimers for activation of MCU is solely controlled by cytosolic Ca(2.).Q42595152
UCPs--unlikely calcium porters.Q43117245
UCP2 modulates single-channel properties of a MCU-dependent Ca(2+) inward current in mitochondriaQ43172590
Protein arginine methyltransferases: guardians of the Arg?Q46780673
Structure and function of the mitochondrial calcium uniporter complexQ28083196
Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complexQ28115674
MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial BioenergeticsQ28116180
MCUR1, CCDC90A, Is a Regulator of the Mitochondrial Calcium UniporterQ28116907
SLC25A23 augments mitochondrial Ca²⁺ uptake, interacts with MCU, and induces oxidative stress-mediated cell deathQ28118248
The Ca(2+)-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca(2+) UptakeQ28118964
PMeS: prediction of methylation sites based on enhanced feature encoding schemeQ28480447
MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handlingQ28486060
Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine productionQ28572237
Tissue-specific and age-dependent expression of protein arginine methyltransferases (PRMTs) in male rat tissuesQ28577818
The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunitQ28591017
PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145Q29871510
Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporterQ30274647
Uncoupling proteins 2 and 3 are fundamental for mitochondrial Ca2+ uniportQ30580904
Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensationQ33936173
Selective inhibition by ethanol of mitochondrial calcium influx mediated by uncoupling protein-2 in relation to N-methyl-D-aspartate cytotoxicity in cultured neuronsQ34854527
Uncoupling protein 3 (UCP3) modulates the activity of Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) by decreasing mitochondrial ATP productionQ35213431
Elevated mRNA-levels of distinct mitochondrial and plasma membrane Ca(2+) transporters in individual hypoglossal motor neurons of endstage SOD1 transgenic miceQ35469175
Expression of mRNA Encoding Mcu and Other Mitochondrial Calcium Regulatory Genes Depends on Cell Type, Neuronal Subtype, and Ca2+ SignalingQ35909268
By Regulating Mitochondrial Ca2+-Uptake UCP2 Modulates Intracellular Ca2+.Q35915724
UCP2 Modulates Cardioprotective Effects of Ru360 in Isolated Cardiomyocytes during IschemiaQ36105811
F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progressionQ36356069
Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS.Q36408540
Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU.Q36490057
RPS3 regulates melanoma cell growth and apoptosis by targeting Cyto C/Ca2+/MICU1 dependent mitochondrial signalingQ36557383
Protein arginine methylation: Cellular functions and methods of analysisQ36607826
Activity of the mitochondrial calcium uniporter varies greatly between tissuesQ37281674
Mitochondrial calcium as a key regulator of mitochondrial ATP production in mammalian cellsQ37444316
MICU1 motifs define mitochondrial calcium uniporter binding and activity.Q37574309
Deacetylation and methylation at histone H3 lysine 9 (H3K9) coordinate chromosome condensation during cell cycle progressionQ37601726
Permanent cell line expressing human factor VIII-related antigen established by hybridizationQ37615209
New aspects of mitochondrial Uncoupling Proteins (UCPs) and their roles in tumorigenesisQ37939833
Mitochondria, calcium-dependent neuronal death and neurodegenerative diseaseQ38012067
Protein arginine methyltransferases and cancerQ38067063
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P304page(s)12897
P577publication date2016-09-19
P1433published inNature CommunicationsQ573880
P1476titlePRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca(2+) uptake in immortalized cells
P478volume7

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cites work (P2860)
Q90028792Akt-mediated phosphorylation of MICU1 regulates mitochondrial Ca2+ levels and tumor growth
Q41699680Endoplasmic Reticulum-Mitochondria Calcium Communication and the Regulation of Mitochondrial Metabolism in Cancer: A Novel Potential Target
Q47943075Endoplasmic Reticulum-Mitochondria Communication Through Ca2+ Signaling: The Importance of Mitochondria-Associated Membranes (MAMs).
Q59330236Enhanced inter-compartmental Ca flux modulates mitochondrial metabolism and apoptotic threshold during aging
Q64228309Glycogen Synthase Kinase 3 Beta Controls Presenilin-1-Mediated Endoplasmic Reticulum Ca²⁺ Leak Directed to Mitochondria in Pancreatic Islets and β-Cells
Q48276594High-affinity cooperative Ca2+ binding by MICU1-MICU2 serves as an on-off switch for the uniporter.
Q57808872Inhibiting Arginine Methylation as a Tool to Investigate Cross-Talk with Methylation and Acetylation Post-Translational Modifications in a Glioblastoma Cell Line
Q38727402Intact mitochondrial Ca2+ uniport is essential for agonist-induced activation of endothelial nitric oxide synthase (eNOS).
Q51734750Intracellular Ca2+ release decelerates mitochondrial cristae dynamics within the junctions to the endoplasmic reticulum.
Q92709621MICU1 controls cristae junction and spatially anchors mitochondrial Ca2+ uniporter complex
Q90381277Mitochondrial Calcium Uniporter Structure and Function in Different Types of Muscle Tissues in Health and Disease
Q47722955Mitochondrial uncoupling proteins: subtle regulators of cellular redox signaling
Q91884279Progress in understanding mitochondrial calcium uniporter complex-mediated calcium signalling: A potential target for cancer treatment
Q96136199S92 phosphorylation induces structural changes in the N-terminus domain of human mitochondrial calcium uniporter
Q39456070Structure, Activity Regulation, and Role of the Mitochondrial Calcium Uniporter in Health and Disease
Q42690071The Role of Mitochondria in the Activation/Maintenance of SOCE: The Contribution of Mitochondrial Ca2+ Uptake, Mitochondrial Motility, and Location to Store-Operated Ca2+ Entry
Q91133678The machineries, regulation and cellular functions of mitochondrial calcium
Q39064771The story of protein arginine methylation: characterization, regulation, and function
Q42508041Through modulation of cardiac Ca2+ handling, UCP2 affects cardiac electrophysiology and influences the susceptibility for Ca2+ -mediated arrhythmias
Q47156190UCP2 and PRMT1 are key prognostic markers for lung carcinoma patients

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