Progress in understanding mitochondrial calcium uniporter complex-mediated calcium signalling: A potential target for cancer treatment

scientific article published on 03 April 2019

Progress in understanding mitochondrial calcium uniporter complex-mediated calcium signalling: A potential target for cancer treatment is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/BPH.14632
P932PMC publication ID6468257
P698PubMed publication ID30801705

P50authorChaochu CuiQ89025723
Liwu FuQ91884275
P2093author name stringJianbo Yang
Xianwei Wang
Mingyong Wang
P2860cites workX-ray and cryo-EM structures of the mitochondrial calcium uniporterQ57181877
Mitochondrial metabolism and cancerQ57842307
Cryo-EM structures of fungal and metazoan mitochondrial calcium uniportersQ59055935
The resolution of calcium fluxes in heart and liver mitochondria using the lanthanide seriesQ61889750
MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake.Q64994458
Specific inhibition of mitochondrial Ca++ transport by ruthenium redQ68468280
A novel isothiourea derivative selectively inhibits the reverse mode of Na+/Ca2+ exchange in cells expressing NCX1Q71514602
Microdomains with high Ca2+ close to IP3-sensitive channels that are sensed by neighboring mitochondriaQ72593109
Bcl-2-dependent modulation of Ca(2+) homeostasis and store-operated channels in prostate cancer cellsQ74372693
Autophagy: Mitochondria encagedQ87901582
Targeting Orai1-mediated store-operated calcium entry by RP4010 for anti-tumor activity in esophagus squamous cell carcinomaQ89125272
Cryo-EM structure of a mitochondrial calcium uniporterQ89324271
MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca2+ and Mn2+Q90785236
Hallmarks of Cancer: The Next GenerationQ22252312
MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptakeQ24294670
MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survivalQ24301822
MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolismQ24304898
Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporterQ24306825
A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporterQ24306850
MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activityQ24338031
EMRE is an essential component of the mitochondrial calcium uniporter complexQ24339589
Mitochondrial calcium signalling and cell death: approaches for assessing the role of mitochondrial Ca2+ uptake in apoptosisQ24649875
A mitochondrial protein compendium elucidates complex I disease biologyQ24655079
The mitochondrial calcium uniporter complex: molecular components, structure and physiopathological implicationsQ26824036
Targeting mitochondria metabolism for cancer therapyQ27027219
CCDC90A (MCUR1) is a cytochrome c oxidase assembly factor and not a regulator of the mitochondrial calcium uniporterQ27938400
Metabolic pathways promoting cancer cell survival and growthQ28086940
Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complexQ28115674
MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial BioenergeticsQ28116180
MCUR1, CCDC90A, Is a Regulator of the Mitochondrial Calcium UniporterQ28116907
The Ca(2+)-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca(2+) UptakeQ28118964
Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosisQ28240946
Mitochondrial fusion and fission in cell life and deathQ28299119
Investigation of mitochondrial dysfunction by sequential microplate-based respiration measurements from intact and permeabilized neuronsQ28482116
MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handlingQ28486060
Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemiaQ28585666
The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunitQ28591017
CaMKII determines mitochondrial stress responses in heartQ28591986
MCU encodes the pore conducting mitochondrial calcium currentsQ29347552
Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responsesQ29616076
Mitochondria and cancerQ29616610
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicityQ29616651
Calcium signalingQ29617338
Mitochondrial control of cell deathQ29617739
Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporterQ33974822
Mitochondrial calcium transport: mechanisms and functionsQ34104032
Mitochondria and calcium signalingQ34441267
After half a century mitochondrial calcium in- and efflux machineries reveal themselvesQ35422412
Calcium uptake by rat kidney mitochondriaQ36441249
Downregulation of the mitochondrial calcium uniporter by cancer-related miR-25Q36518486
Effective killing of leukemia cells by the natural product OSW-1 through disruption of cellular calcium homeostasisQ36579514
Regulation of mitochondrial ATP synthesis by calcium: evidence for a long-term metabolic primingQ36702104
Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transitionQ36770526
Cloning of two isoforms of the rat brain Na(+)-Ca2+ exchanger gene and their functional expression in HeLa cellsQ36778221
Ion channels in death and differentiation of prostate cancer cells.Q36811138
Minocycline: far beyond an antibioticQ36836358
Calcium and cancer: targeting Ca2+ transportQ36856463
The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1α.Q36895350
Probing novel roles of the mitochondrial uniporter in ovarian cancer cells using nanoparticlesQ36929055
Mitochondrial complex III regulates hypoxic activation of HIF.Q37064874
Mitochondria: the hub of cellular Ca2+ signalingQ37133622
Mitochondrial control of calcium-channel gating: a mechanism for sustained signaling and transcriptional activation in T lymphocytesQ37253977
Activity of the mitochondrial calcium uniporter varies greatly between tissuesQ37281674
The apoptotic members CD95, BclxL, and Bcl-2 cooperate to promote cell migration by inducing Ca(2+) flux from the endoplasmic reticulum to mitochondriaQ37294307
Mitochondrial permeability transition in Ca(2+)-dependent apoptosis and necrosisQ37878020
Mitochondrial Ca(2+) and apoptosisQ38000429
Mitochondria as sensors and regulators of calcium signallingQ38031124
MCU-dependent mitochondrial Ca(2+) inhibits NAD(+)/SIRT3/SOD2 pathway to promote ROS production and metastasis of HCC cellsQ38709048
Ion and inhibitor binding of the double-ring ion selectivity filter of the mitochondrial calcium uniporterQ38888678
Mitochondrial Ca²⁺ uniporter is critical for store-operated Ca²⁺ entry-dependent breast cancer cell migration.Q38914237
Targeting calcium signaling in cancer therapyQ39101957
Mitochondrial calcium uniporter silencing potentiates caspase-independent cell death in MDA-MB-231 breast cancer cells.Q39163399
Mitochondrial modulation decreases the bortezomib-resistance in multiple myeloma cellsQ39184945
Interplay of reactive oxygen species, intracellular Ca2+ and mitochondrial homeostasis in the apoptosis of prostate cancer cells by deoxypodophyllotoxinQ39236166
PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca(2+) uptake in immortalized cellsQ39376053
Structural Insights into Mitochondrial Calcium Uniporter Regulation by Divalent CationsQ39445564
Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.Q39676476
Store-operated Ca2+ entry depends on mitochondrial Ca2+ uptakeQ39693203
The in vivo inhibition of tumor growth by ruthenium red: its relationship with the metabolism of calcium in the tumorQ39737590
Minocycline and doxycycline, but not other tetracycline-derived compounds, protect liver cells from chemical hypoxia and ischemia/reperfusion injury by inhibition of the mitochondrial calcium uniporter.Q39764384
Orai1 and STIM1 are critical for breast tumor cell migration and metastasisQ39888627
The plasma membrane Na+/Ca2+ exchange inhibitor KB-R7943 is also a potent inhibitor of the mitochondrial Ca2+ uniporter.Q40217577
Mitochondrial-mediated disregulation of Ca2+ is a critical determinant of Velcade (PS-341/bortezomib) cytotoxicity in myeloma cell linesQ40427680
Mitochondrial calcium uniporter, MiRNA and cancer: Live and let die.Q40768860
DS16570511 is a small-molecule inhibitor of the mitochondrial calcium uniporterQ41024258
ER-mitochondria signaling regulates autophagyQ41138057
KB-R7943, an inhibitor of the reverse Na+ /Ca2+ exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex I.Q41539954
Mitofusin-2 triggers mitochondria Ca2+ influx from the endoplasmic reticulum to induce apoptosis in hepatocellular carcinoma cellsQ41581462
MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporterQ41976396
HINT2 triggers mitochondrial Ca2+ influx by regulating the mitochondrial Ca2+ uniporter (MCU) complex and enhances gemcitabine apoptotic effect in pancreatic cancerQ41994387
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: TransportersQ42660436
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: EnzymesQ42660454
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: OverviewQ42660459
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Other ion channelsQ42660466
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Ligand-gated ion channels.Q42660492
The mitochondrial calcium uniporter is a highly selective ion channel.Q44737530
MCUR1-Mediated Mitochondrial Calcium Signaling Facilitates Cell Survival of Hepatocellular Carcinoma via Reactive Oxygen Species-Dependent P53 DegradationQ46302560
Mitochondrial Ca2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity.Q46408932
Doxycycline as Potential Anti-Cancer Agent.Q46510547
Differential role of transient receptor potential channels in Ca2+ entry and proliferation of prostate cancer epithelial cells.Q46952740
MICU2 Restricts Spatial Crosstalk between InsP3R and MCU Channels by Regulating Threshold and Gain of MICU1-Mediated Inhibition and Activation of MCU.Q47118758
The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY.Q47139831
Mitochondrial calcium uniporter as a target of microRNA-340 and promoter of metastasis via enhancing the Warburg effect.Q47143083
Systematic Identification of MCU Modulators by Orthogonal Interspecies Chemical ScreeningQ47935016
Ca2+ binding to F-ATP synthase β subunit triggers the mitochondrial permeability transitionQ48061561
High-affinity cooperative Ca2+ binding by MICU1-MICU2 serves as an on-off switch for the uniporter.Q48276594
Content of mitochondrial calcium uniporter (MCU) in cardiomyocytes is regulated by microRNA-1 in physiologic and pathologic hypertrophyQ50089772
Dynamics of mitochondrial Ca2+ uptake in MICU1-knockdown cells.Q50482635
Therapeutic advantage of combining calcium channel blockers and TRAIL in prostate cancer.Q52573066
Calcium orchestrates apoptosis.Q54055382
RIPK1 binds MCU to mediate induction of mitochondrial Ca2+ uptake and promote colorectal oncogenesis.Q54121779
P433issue9
P304page(s)1190-1205
P577publication date2019-04-03
P1433published inBritish Journal of PharmacologyQ919631
P1476titleProgress in understanding mitochondrial calcium uniporter complex-mediated calcium signalling: A potential target for cancer treatment
P478volume176