The (pro)renin receptor and its interaction partners.

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The (pro)renin receptor and its interaction partners. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/S00424-017-2005-Z
P698PubMed publication ID28620832

P50authorJ PetersQ87856608
P2860cites workRequirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signalingQ24296846
A unique exonic splice enhancer mutation in a family with X-linked mental retardation and epilepsy points to a novel role of the renin receptorQ24297376
Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to reninQ24298747
Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanismsQ24299673
Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granulesQ24309312
Mitotic and mitogenic Wnt signallingQ27021818
Human prorenin structure sheds light on a novel mechanism of its autoinhibition and on its non-proteolytic activation by the (pro)renin receptorQ27679015
TOR signaling in growth and metabolismQ27860757
The tyrosine phosphatase PRL-1 localizes to the endoplasmic reticulum and the mitotic spindle and is required for normal mitosisQ28202194
The vacuolar (H+)-ATPases--nature's most versatile proton pumpsQ28218190
Drosophila ATP6AP2/VhaPRR functions both as a novel planar cell polarity core protein and a regulator of endosomal traffickingQ28512268
Autophagy as a regulated pathway of cellular degradationQ29547914
Vacuolar ATPases: rotary proton pumps in physiology and pathophysiologyQ29614686
Nephron-specific deletion of the prorenin receptor causes a urine concentration defectQ30299906
Conditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegenerationQ30399284
The V-ATPase membrane domain is a sensor of granular pH that controls the exocytotic machineryQ30555694
Signaling angiogenesis via p42/p44 MAP kinase and hypoxiaQ34047250
Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomesQ34156430
The role of the renin-angiotensin system in the development of cardiovascular diseaseQ34522515
Polycystic kidney disease: cell division without a c(l)ue?Q34544069
A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger proteinQ34578959
Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic ratsQ34627296
Intracellular sorting of renin: cell type specific differences and their consequencesQ35035369
The role of individual domains and the significance of shedding of ATP6AP2/(pro)renin receptor in vacuolar H(+)-ATPase biogenesisQ35040988
The Wnt adaptor protein ATP6AP2 regulates multiple stages of adult hippocampal neurogenesis.Q35316183
ATP6AP2/(pro)renin receptor contributes to glucose metabolism via stabilizing the pyruvate dehydrogenase E1 β subunitQ35351912
Vacuolar ATPase in phagosome-lysosome fusion.Q35662382
Prorenin receptor is essential for podocyte autophagy and survivalQ35758247
Renin, prorenin and the putative (pro)renin receptorQ36269055
Cilia, Wnt signaling, and the cytoskeletonQ36564463
Soluble (pro)renin receptor via β-catenin enhances urine concentration capability as a target of liver X receptorQ36770595
Adipocyte (Pro)Renin-Receptor Deficiency Induces Lipodystrophy, Liver Steatosis and Increases Blood Pressure in Male MiceQ36989385
Critical review of prorenin and (pro)renin receptor researchQ37112367
A role of the (pro)renin receptor in neuronal cell differentiationQ37298439
Lack of cardiac fibrosis in a new model of high prorenin hyperaldosteronismQ37430944
Neuron-specific (pro)renin receptor knockout prevents the development of salt-sensitive hypertensionQ37626138
Signal transduction of the (pro)renin receptor as a novel therapeutic target for preventing end-organ damageQ37654714
Human proreninQ37687876
Morphology, physiology, and molecular biology of renin secretionQ37969158
The complex world of WNT receptor signallingQ38059785
(Pro)renin receptor: subcellular localizations and functionsQ38070563
Wnt-signaling and planar cell polarity genes regulate axon guidance along the anteroposterior axis in C. elegansQ38161449
The (pro)renin receptor blocker handle region peptide upregulates endothelium-derived contractile factors in aliskiren-treated diabetic transgenic (mREN2)27 ratsQ38318682
The Role of the (Pro)renin Receptor in Hypertensive DiseaseQ38428278
The (pro)renin receptor ((P)RR) can act as a repressor of Wnt signallingQ39269454
The (pro)renin receptor is cleaved by ADAM19 in the Golgi leading to its secretion into extracellular space.Q39602112
Ovarian proreninQ39669123
Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of proreninQ40176844
The renin-angiotensin system in the heart and vascular wall: new therapeutic aspectsQ40616239
(Pro)renin receptor (ATP6AP2) depletion arrests As4.1 cells in the G0/G1 phase thereby increasing formation of primary ciliaQ41021509
Plasma prorenin as an early marker of microvascular disease in patients with diabetes mellitusQ41085037
(Pro)renin receptor-mediated signal transduction and tissue renin-angiotensin system contribute to diabetes-induced retinal inflammationQ41275103
High concentrations of immunoreactive renin, prorenin and enzymatically-active renin in human ovarian follicular fluid.Q41452943
Site-directed mutagenesis of human prorenin. Substitution of three arginine residues in the propeptide with glutamine residues yields active proreninQ41752186
Inhibition of MTOR disrupts autophagic flux in podocytesQ41812610
Plasma prorenin activity and complications in children with insulin-dependent diabetes mellitusQ41828099
The (pro)renin receptor/ATP6AP2 is essential for vacuolar H+-ATPase assembly in murine cardiomyocytes.Q41935568
Involvement of the brain (pro)renin receptor in cardiovascular homeostasisQ42415303
Serum level of soluble (pro)renin receptor is modulated in chronic kidney diseaseQ42436836
RILLKKMPSV influences the vasculature, neurons and glia, and (pro)renin receptor expression in the retinaQ43109188
Expression of (pro)renin receptor in the human brain and pituitary, and co-localisation with arginine vasopressin and oxytocin in the hypothalamusQ43159075
The (pro)renin receptor / ATP6ap2 is expressed in the murine hippocampus by adult and newly generated neurons.Q43709761
A specific binding site for the prorenin propart peptide Arg10-Arg20 does not occur on human endothelial cellsQ43856359
Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptideQ46796595
(Pro)renin receptor peptide inhibitor "handle-region" peptide does not affect hypertensive nephrosclerosis in Goldblatt ratsQ46796597
Dose-dependent titration of prorenin and blood pressure in Cyp1a1ren-2 transgenic rats: absence of prorenin-induced glomerulosclerosisQ46842966
Regulation of Frizzled-dependent planar polarity signaling by a V-ATPase subunitQ47072606
Wnt/Frizzled signaling requires dPRR, the Drosophila homolog of the prorenin receptor.Q47072772
Soluble form of the (pro)renin receptor generated by intracellular cleavage by furin is secreted in plasmaQ47977163
New role for the (pro)renin receptor in T-cell developmentQ50582982
Atp6ap2/(pro)renin receptor interacts with Par3 as a cell polarity determinant required for laminar formation during retinal development in mice.Q50704975
Renin-1 Is Essential for Normal Renal Juxtaglomerular Cell Granulation and Macula Densa MorphologyQ50947288
Prediction of gestational diabetes mellitus by soluble (pro)renin receptor during the first trimesterQ50950703
Granulation rescue and developmental marking of juxtaglomerular cells using "piggy-BAC" recombination of the mouse ren locus.Q52165156
Increased expression of (pro)renin receptor does not cause hypertension or cardiac and renal fibrosis in mice.Q52875203
Renin- and prorenin-induced effects in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor: does (pro)renin-(pro)renin receptor interaction actually occur?Q53210609
Handle region peptide counteracts the beneficial effects of the Renin inhibitor aliskiren in spontaneously hypertensive rats.Q54387733
Soluble (pro)renin receptor and blood pressure during pregnancy: a prospective cohort study.Q54479012
Effect of (pro)renin receptor inhibition by a decoy peptide on renal damage in the clipped kidney of Goldblatt ratsQ56985236
Microalbuminuria and increased plasma prorenin. Prevalence in diabetics followed up for four yearsQ68131940
Prorenin in high concentrations in human ovarian follicular fluidQ68898242
Increased plasma inactive renin in diabetes mellitus. A marker of microvascular complicationsQ69890202
Targeted inactivation of the Ren-2 gene in miceQ71853661
Increase in serum prorenin precedes onset of microalbuminuria in patients with insulin-dependent diabetes mellitusQ73005633
Human prorenin has "gate and handle" regions for its non-proteolytic activationQ73235262
Plasma prorenin levels may predict persistent microalbuminuria in children with diabetesQ73653024
Mannose 6-phosphate receptor-mediated internalization and activation of prorenin by cardiac cellsQ73951396
Uptake and proteolytic activation of prorenin by cultured human endothelial cellsQ77994379
Chronic increases in circulating prorenin are not associated with renal or cardiac pathologiesQ83643707
Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor-deficient miceQ83886178
Involvement of receptor-bound prorenin in development of nephropathy in diabetic db/db miceQ84088936
Deterioration of kidney function by the (pro)renin receptor blocker handle region peptide in aliskiren-treated diabetic transgenic (mRen2)27 ratsQ87593501
P433issue10
P304page(s)1245-1256
P577publication date2017-06-15
P1433published inPfluegers ArchivQ1091689
P1476titleThe (pro)renin receptor and its interaction partners
P478volume469