Cilia, Wnt signaling, and the cytoskeleton

scientific article published on 2 May 2012

Cilia, Wnt signaling, and the cytoskeleton is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P6179Dimensions Publication ID1049704746
P356DOI10.1186/2046-2530-1-7
P932PMC publication ID3555707
P698PubMed publication ID23351924
P5875ResearchGate publication ID235374058

P2093author name stringMatthew W Kelley
Helen L May-Simera
P2860cites workThe Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complexQ21145025
Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor proteinQ22008584
The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assemblyQ24293516
BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assemblyQ24295491
Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methodsQ24296940
Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathwayQ24300418
Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signalingQ24301800
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathwaysQ24302034
Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesisQ24304699
Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamicsQ24305196
A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesisQ24311615
Motile cilia of human airway epithelia are chemosensoryQ24317210
Regulation of planar cell polarity by Smurf ubiquitin ligasesQ24317525
APC binds to the novel protein EB1Q24317778
Ciliary and centrosomal defects associated with mutation and depletion of the Meckel syndrome genes MKS1 and MKS3Q24337720
Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease.Q51953017
Cdc42 controls the polarity of the actin and microtubule cytoskeletons through two distinct signal transduction pathways.Q53673562
Observations on axonemes and membranes of olfactory and respiratory cilia in frogs and rats using tannic acid-supplemented fixation and photographic rotationQ72736596
The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progressionQ24337908
Cep97 and CP110 suppress a cilia assembly programQ24338361
CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficient in human ciliary diseaseQ24568058
Intraflagellar transport molecules in ciliary and nonciliary cells of the retinaQ24595309
Scaffold proteins: hubs for controlling the flow of cellular informationQ24611517
Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndromeQ24622660
Mutations in TMEM216 perturb ciliogenesis and cause Joubert, Meckel and related syndromesQ24625476
Intraflagellar transport motors in cilia: moving along the cell's antennaQ24645583
Centrioles in the cell cycle. I. Epithelial cellsQ24681444
Spectrum of clinical diseases caused by disorders of primary ciliaQ27024881
Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndromeQ27919661
MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesisQ28000044
Ciliogenesis: building the cell's antennaQ28000047
Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activityQ28114807
Intraflagellar transportQ28131775
Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determinationQ28188363
Critical role for the EB1 and APC interaction in the regulation of microtubule polymerizationQ28208418
Depletion of centromeric MCAK leads to chromosome congression and segregation defects due to improper kinetochore attachmentsQ28236606
Cdc42--the centre of polarityQ28250444
FGF-dependent left-right asymmetry patterning in zebrafish is mediated by Ier2 and Fibp1Q28312172
Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway componentsQ28505068
PCP effector gene Inturned is an important regulator of cilia formation and embryonic development in mammalsQ28505120
Fuz controls the morphogenesis and differentiation of hair follicles through the formation of primary ciliaQ28505257
Planar cell polarity effector gene Fuzzy regulates cilia formation and Hedgehog signal transduction in mouseQ28505727
Impaired Wnt-beta-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathyQ28506100
An Ift80 mouse model of short rib polydactyly syndromes shows defects in hedgehog signalling without loss or malformation of ciliaQ28506229
Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebratesQ28506652
A role for the primary cilium in Notch signaling and epidermal differentiation during skin developmentQ28510710
Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalusQ28511503
Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair folliclesQ28513824
The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic developmentQ28584722
The subcellular destinations of APC proteinsQ34623795
Ciliopathies: an expanding disease spectrumQ34626170
Nde1-mediated inhibition of ciliogenesis affects cell cycle re-entryQ34796294
Centriole age underlies asynchronous primary cilium growth in mammalian cellsQ34997578
Defective Wnt-dependent cerebellar midline fusion in a mouse model of Joubert syndromeQ35032831
The small GTPase Cdc42 is necessary for primary ciliogenesis in renal tubular epithelial cellsQ35063130
EB1 and EB3 promote cilia biogenesis by several centrosome-related mechanismsQ35112285
Cilium, centrosome and cell cycle regulation in polycystic kidney disease.Q35112926
Cell biological regulation of division fate in vertebrate neuroepithelial cellsQ35116856
Accumulation of the Raf-1 kinase inhibitory protein (Rkip) is associated with Cep290-mediated photoreceptor degeneration in ciliopathiesQ35150162
NPHP4, a cilia-associated protein, negatively regulates the Hippo pathwayQ35196050
Cilia and cell cycle re-entry: more than a coincidenceQ35559947
ARF family G proteins and their regulators: roles in membrane transport, development and disease.Q35632439
STAM and Hrs down-regulate ciliary TRP receptorsQ35949117
APC is a component of an organizing template for cortical microtubule networksQ36012265
Adenomatous polyposis coli and EB1 localize in close proximity of the mother centriole and EB1 is a functional component of centrosomes.Q36012450
Cdc42 and noncanonical Wnt signal transduction pathways cooperate to promote cell polarityQ36119733
The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.Q36237136
Asymmetric centrosome behavior and the mechanisms of stem cell divisionQ36404828
Asymmetric stem cell division and function of the niche in the Drosophila male germ lineQ36420003
Planar cell polarity acts through septins to control collective cell movement and ciliogenesis.Q36433141
Lucky 13-microtubule depolymerisation by kinesin-13 motorsQ36599332
What is the function of centrioles?Q36658029
Wnt signalling and the actin cytoskeletonQ36672682
Centrosome duplication: of rules and licensesQ36769585
Intraflagellar transport: from molecular characterisation to mechanismQ36992512
Functional modules, mutational load and human genetic diseaseQ37086760
Assembly of primary ciliaQ37130367
Building it up and taking it down: the regulation of vertebrate ciliogenesisQ37147143
Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without ciliaQ37314322
Planar cell polarity signaling: the developing cell's compass.Q37412656
Making sense of cilia in disease: the human ciliopathies.Q37624563
Planar cell polarity: keeping hairs straight is not so simpleQ37698284
CEP290, a gene with many faces: mutation overview and presentation of CEP290base.Q37778326
Mechanisms of mammalian ciliary motility: Insights from primary ciliary dyskinesia geneticsQ37812789
Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and ciliaQ37834841
Kinesins and protein kinases: key players in the regulation of microtubule dynamics and organizationQ37846270
Regulating the transition from centriole to basal bodyQ37871223
Ultrastructure of cilia and flagella - back to the future!Q37897615
Inversin, Wnt signaling and primary ciliaQ37972186
Polarity proteins control ciliogenesis via kinesin motor interactionsQ38337461
Ciliary transition zone activation of phosphorylated Tctex-1 controls ciliary resorption, S-phase entry and fate of neural progenitorsQ39537369
Primary cilia regulate mTORC1 activity and cell size through Lkb1.Q39640418
Aberrant activation of fatty acid synthesis suppresses primary cilium formation and distorts tissue development.Q39648686
Flow modulates centriole movements in tubular epithelial cellsQ39990068
MCAK associates with EB1.Q40060454
Adenomatous polyposis coli (APC) protein moves along microtubules and concentrates at their growing ends in epithelial cellsQ40901818
Fine mapping of regulatory loci for mammalian gene expression using radiation hybridsQ41588995
Asymmetric inheritance of mother versus daughter centrosome in stem cell divisionQ41956545
The PCP pathway instructs the planar orientation of ciliated cells in the Xenopus larval skinQ42113899
The Microtubule plus end-tracking protein EB1 is localized to the flagellar tip and basal bodies in Chlamydomonas reinhardtiiQ42452654
Coupling between hydrodynamic forces and planar cell polarity orients mammalian motile ciliaQ42469073
Bbs8, together with the planar cell polarity protein Vangl2, is required to establish left-right asymmetry in zebrafish.Q42474570
Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signalingQ42491186
Sperm ultrastructure and spermiogenesis of Coniopterygidae (Neuroptera, Insecta).Q43772808
Adenomatous polyposis coli associates with the microtubule-destabilizing protein XMCAK.Q45158402
Regulation of primary cilia formation and left-right patterning in zebrafish by a noncanonical Wnt signaling mediator, duborayaQ46486197
FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination.Q46486386
Defective planar cell polarity in polycystic kidney diseaseQ46845250
Genome-wide analysis identifies a general requirement for polarity proteins in endocytic trafficQ47068800
Planar cell polarity signalling regulates cell adhesion properties in progenitors of the zebrafish laterality organQ47073220
Vangl2 directs the posterior tilting and asymmetric localization of motile primary cilia.Q47073501
Cystic kidney gene seahorse regulates cilia-mediated processes and Wnt pathwaysQ47073543
Dishevelled promotes axon differentiation by regulating atypical protein kinase C.Q48142245
Inactivation of Chibby affects function of motile airway ciliaQ28585930
Ciliary proteins link basal body polarization to planar cell polarity regulationQ28585995
Disruption of IFT complex A causes cystic kidneys without mitotic spindle misorientationQ28587960
Ahi1, whose human ortholog is mutated in Joubert syndrome, is required for Rab8a localization, ciliogenesis and vesicle traffickingQ28588535
Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closureQ28588549
Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney diseaseQ28592609
Hedgehog signalling in the mouse requires intraflagellar transport proteinsQ28593010
Identification of Vangl2 and Scrb1 as planar polarity genes in mammalsQ28593071
Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosisQ28633869
The primary cilium: a signalling centre during vertebrate developmentQ29547197
Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanismsQ29614613
PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblastsQ29614616
Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathwaysQ29614619
CEP290 tethers flagellar transition zone microtubules to the membrane and regulates flagellar protein content.Q29614822
The primary cilium as the cell's antenna: signaling at a sensory organelleQ29615165
Towards an integrated view of Wnt signaling in developmentQ29615175
The primary cilium as a complex signaling centerQ29615254
Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt responseQ29617051
Two populations of node monocilia initiate left-right asymmetry in the mouseQ29617071
Centrosome composition and microtubule anchoring mechanismsQ29619588
Centrioles and the formation of rudimentary cilia by fibroblasts and smooth muscle cellsQ29620499
Par3 functions in the biogenesis of the primary cilium in polarized epithelial cellsQ30441567
The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growthQ30480543
Dual role of Cdc42 in spindle orientation control of adherent cellsQ30487617
Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cellsQ30491381
Loss of oriented cell division does not initiate cyst formationQ30493527
Intraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapseQ30493645
Planar cell polarity breaks bilateral symmetry by controlling ciliary positioningQ30499162
The cilia protein IFT88 is required for spindle orientation in mitosisQ30499405
Planar cell polarity enables posterior localization of nodal cilia and left-right axis determination during mouse and Xenopus embryogenesis.Q30977459
Patterns of expression of Bardet-Biedl syndrome proteins in the mammalian cochlea suggest noncentrosomal functionsQ33435460
Primary cilia are not required for normal canonical Wnt signaling in the mouse embryo.Q33498502
Wnt regulates spindle asymmetry to generate asymmetric nuclear β-catenin in C. elegansQ34021395
Primary cilia regulate branching morphogenesis during mammary gland development.Q34047857
KIF17 stabilizes microtubules and contributes to epithelial morphogenesis by acting at MT plus ends with EB1 and APC.Q34069997
Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathwayQ34186612
The intraflagellar transport component IFT88/polaris is a centrosomal protein regulating G1-S transition in non-ciliated cellsQ34607735
P275copyright licenseCreative Commons Attribution 2.0 GenericQ19125117
P6216copyright statuscopyrightedQ50423863
P433issue1
P921main subjectcytoskeletonQ154626
P304page(s)7
P577publication date2012-05-02
P1433published inCiliaQ27724298
P1476titleCilia, Wnt signaling, and the cytoskeleton
P478volume1

Reverse relations

cites work (P2860)
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