Exendin-4 increases the expression of hypoxia-inducible factor-1α in rat islets and preserves the endocrine cell volume of both free and macroencapsulated islet grafts

scientific article

Exendin-4 increases the expression of hypoxia-inducible factor-1α in rat islets and preserves the endocrine cell volume of both free and macroencapsulated islet grafts is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3727/096368911X627408
P698PubMed publication ID22405036

P2093author name stringFeng Wang
Amit Sharma
Shinji Yamamoto
Xiaohui Jia
Makiko Kumagai-Braesch
Anne K Sörenby
Annika B Tibell
Annika M Wernerson
P2860cites workIslet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimenQ28141785
Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic ratsQ28578709
Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human isletsQ28591503
Inflammation blockade improves pancreatic islet functionQ30435500
Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B.Q33215328
Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expressionQ34770083
Islet transplantation for brittle type 1 diabetes: the UIC protocolQ34774804
Long-term insulin independence and improvement in insulin secretion after supplemental islet infusion under exenatide and etanerceptQ37381194
Glucagon-like peptide-1 analog and insulin combination therapy in the management of adults with type 2 diabetes mellitusQ37763417
Beneficial effects of desferrioxamine on encapsulated human islets--in vitro and in vivo studyQ39677920
Establishment of mouse pancreatic stem cell lineQ39796077
Further Characterization of a Rat Ovarian Testosterone Receptor with Evidence for Nuclear TranslocationQ40007274
Exendin 4 controls insulin production in rat islet beta cells predominantly by potentiation of glucose-stimulated proinsulin biosynthesis at the translational levelQ42503036
Glucose Sensitivity and Metabolism-Secretion Coupling Studied during Two-Year Continuous Culture in INS-1E Insulinoma CellsQ42798453
Long-term metabolic and hormonal effects of exenatide on islet transplant recipients with allograft dysfunctionQ43225003
Exendin-4 normalized postcibal glycemic excursions in type 1 diabetesQ44968815
Improved histological evaluation of vascularity around an immunoisolation device by correlating number of vascular profiles to glucose exchangeQ45222560
The portal immunosuppressive storm: relevance to islet transplantation?Q45234964
Effect of donor treatment with heparinoids on graft function after intraportal transplantation of a marginal islet mass: an experimental studyQ45248085
Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreasQ46364782
Preimplantation of an immunoprotective device can lower the curative dose of islets to that of free islet transplantation: studies in a rodent modelQ46470363
Islet transplantation outcomes in mice are better with fresh islets and exendin-4 treatmentQ46678794
GLP-1 receptor signaling protects pancreatic beta cells in intraportal islet transplant by inhibiting apoptosisQ46796844
Intraislet endothelial cells contribute to revascularization of transplanted pancreatic isletsQ47690560
Beneficial role of pancreatic microenvironment for angiogenesis in transplanted pancreatic islets.Q47708847
Reversal of hyperglycemia in mice after subcutaneous transplantation of macroencapsulated islets.Q51468524
A comparison of twice-daily exenatide and biphasic insulin aspart in patients with type 2 diabetes who were suboptimally controlled with sulfonylurea and metformin: a non-inferiority study.Q51483637
Incompatibility between human blood and isolated islets of Langerhans: a finding with implications for clinical intraportal islet transplantation?Q52536571
Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function.Q53591473
Exendin-4 treatment improves metabolic control after rat islet transplantation to athymic mice with streptozotocin-induced diabetes.Q53627911
P433issue6
P304page(s)1269-1283
P577publication date2012-03-08
P1433published inCell TransplantationQ15761863
P1476titleExendin-4 increases the expression of hypoxia-inducible factor-1α in rat islets and preserves the endocrine cell volume of both free and macroencapsulated islet grafts
P478volume21

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cites work (P2860)
Q39189393Dual factor delivery of CXCL12 and Exendin-4 for improved survival and function of encapsulated beta cells under hypoxic conditions
Q34512289Enhancing human islet transplantation by localized release of trophic factors from PLG scaffolds
Q53256328High Seeding Density Induces Local Hypoxia and Triggers a Proinflammatory Response in Isolated Human Islets.
Q88963353Insulin-producing Cells from Adult Human Bone Marrow Mesenchymal Stromal Cells Could Control Chemically Induced Diabetes in Dogs: A Preliminary Study
Q56875353The TheraCyte™ Device Protects against Islet Allograft Rejection in Immunized Hosts
Q27013927Use of glucagon-like peptide-1 agonists to improve islet graft performance

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