Role of the small GTPase Rap1 in signal transduction, cell dynamics and bacterial infection.

scientific article

Role of the small GTPase Rap1 in signal transduction, cell dynamics and bacterial infection. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1080/21541248.2017.1331721
P932PMC publication ID6748356
P698PubMed publication ID28632994

P50authorHubert HilbiQ58981515
Arjan KortholtQ60976005
P2093author name stringArjan Kortholt
Hubert Hilbi
P2860cites workRIAM activates integrins by linking talin to ras GTPase membrane-targeting sequencesQ24652493
Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytesQ26823331
IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic AcidQ27316130
Activation of Ran GTPase by a Legionella effector promotes microtubule polymerization, pathogen vacuole motility and infectionQ27333488
Structure of a double ubiquitin-like domain in the talin head: a role in integrin activationQ27659768
Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detectorQ27674334
Purification and proteomics of pathogen-modified vacuoles and membranesQ28080622
The guanine nucleotide-binding switch in three dimensionsQ28131710
Proteome analysis of Legionella vacuoles purified by magnetic immunoseparation reveals secretory and endosomal GTPasesQ28299601
Rap1 activation is required for Fc gamma receptor-dependent phagocytosisQ28565336
A Rap/phosphatidylinositol 3-kinase pathway controls pseudopod formation [corrected].Q30493612
A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migrationQ30495196
GxcC connects Rap and Rac signaling during Dictyostelium developmentQ30540406
Legionella pneumophila exploits PI(4)P to anchor secreted effector proteins to the replicative vacuoleQ33243973
Human RAS superfamily proteins and related GTPasesQ33689727
Molecular pathogenesis of infections caused by Legionella pneumophilaQ33825611
Regulating Rap small G-proteins in time and spaceQ34206255
Mitotic rounding alters cell geometry to ensure efficient bipolar spindle formationQ34341559
MAPK signal pathways in the regulation of cell proliferation in mammalian cellsQ34593370
Rap1-dependent pathways coordinate cytokinesis in DictyosteliumQ34680430
Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxisQ46458035
Isolation of Legionella-containing vacuoles by immuno-magnetic separation.Q48822809
RasGEF-containing proteins GbpC and GbpD have differential effects on cell polarity and chemotaxis in Dictyostelium.Q50771615
Legionella spp. outdoors: colonization, communication and persistence.Q50913097
Rap1 activation in response to cAMP occurs downstream of ras activation during Dictyostelium aggregation.Q51967719
RapGAP9 regulation of the morphogenesis and development in Dictyostelium.Q53067203
Covalent Coercion by Legionella pneumophilaQ59662924
IFN-gamma activates the C3G/Rap1 signaling pathwayQ73406992
The Legionella pneumophila phosphatidylinositol-4 phosphate-binding type IV substrate SidC recruits endoplasmic reticulum vesicles to a replication-permissive vacuoleQ81730696
Dynamic changes in Rap1 activity are required for cell retraction and spreading during mitosisQ34994560
Cellular functions of the Rap1 GTP-binding protein: a pattern emergesQ35036819
Minimization of the Legionella pneumophila genome reveals chromosomal regions involved in host range expansionQ35202685
Multiple substrates of the Legionella pneumophila Dot/Icm system identified by interbacterial protein transfer.Q35554474
The Rap1-Rgl-Ral signaling network regulates neuroblast cortical polarity and spindle orientationQ35670607
Rap1 controls cell adhesion and cell motility through the regulation of myosin II.Q36118074
Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factorsQ36322667
Rap1: a turnabout for the crosstalk between cadherins and integrinsQ36425017
Regulation of chemotaxis by the orchestrated activation of Ras, PI3K, and TOR.Q36494719
Direct Interaction between TalinB and Rap1 is necessary for adhesion of Dictyostelium cellsQ36883771
Highlighting the role of Ras and Rap during Dictyostelium chemotaxisQ37126989
The Legionella pneumophila replication vacuole: making a cosy niche inside host cellsQ37326393
Localized diacylglycerol-dependent stimulation of Ras and Rap1 during phagocytosis.Q37431056
Regulation of actin cytoskeleton by Rap1 binding to RacGEF1.Q37461797
Rap1, a mercenary among the Ras-like GTPasesQ37671129
Modulation of Host Cell Function byLegionella pneumophilaType IV EffectorsQ37798551
Subversion of Retrograde Trafficking by Translocated Pathogen EffectorsQ37837300
Phosphoinositide lipids and the Legionella pathogen vacuoleQ38126839
A Rab-centric perspective of bacterial pathogen-occupied vacuoles.Q38137410
The natural alternative: protozoa as cellular models for Legionella infectionQ38156244
Formation of a pathogen vacuole according to Legionella pneumophila: how to kill one bird with many stones.Q38436575
Functional analysis of novel Rab GTPases identified in the proteome of purified Legionella-containing vacuoles from macrophages.Q38438441
Icm/Dot-dependent inhibition of phagocyte migration by Legionella is antagonized by a translocated Ran GTPase activator.Q39036824
Delineation of the roles played by RasG and RasC in cAMP-dependent signal transduction during the early development of Dictyostelium discoideumQ39084334
The Legionella effector RidL inhibits retrograde trafficking to promote intracellular replication.Q39123373
Pathogen vacuole purification from legionella-infected amoeba and macrophagesQ39245223
Rap1 controls activation of the αMβ2 integrin in a talin‐dependent mannerQ39674641
A Gα-Stimulated RapGEF Is a Receptor-Proximal Regulator of Dictyostelium ChemotaxisQ39756806
Dictyostelium chemotaxis: essential Ras activation and accessory signalling pathways for amplificationQ39985505
Chemoattractant-induced Ras activation during Dictyostelium aggregationQ40102452
Role of phosphatidylinositol 3-kinases in chemotaxis in DictyosteliumQ40164677
Characterization of the GbpD-activated Rap1 pathway regulating adhesion and cell polarity in Dictyostelium discoideumQ40268739
Comparative Proteomics of Purified Pathogen Vacuoles Correlates Intracellular Replication of Legionella pneumophila with the Small GTPase Ras-related protein 1 (Rap1).Q40338157
A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomesQ40754890
Regulation of Rap1 activity by RapGAP1 controls cell adhesion at the front of chemotaxing cellsQ40802715
The small GTPases Ras and Rap1 bind to and control TORC2 activityQ41508599
Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movementQ42053161
Evidence for a role for the Dictyostelium Rap1 in cell viability and the response to osmotic stressQ44108513
P433issue5
P304page(s)336-342
P577publication date2017-06-23
P1433published inSmall GTPases (journal)Q15709529
P1476titleRole of the small GTPase Rap1 in signal transduction, cell dynamics and bacterial infection
P478volume10