Molecular pathogenesis of infections caused by Legionella pneumophila

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Molecular pathogenesis of infections caused by Legionella pneumophila is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1128/CMR.00052-09
P932PMC publication ID2863363
P698PubMed publication ID20375353
P5875ResearchGate publication ID43073311

P50authorElizabeth L. HartlandQ47502191
Hayley J. NewtonQ48232510
Ian R van DrielQ37830536
Desmond K Y AngQ116996163
P2860cites workMolecular mimicry by an F-box effector of Legionella pneumophila hijacks a conserved polyubiquitination machinery within macrophages and protozoaQ21131567
Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticityQ22122047
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequenceQ22122411
The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7Q24292473
RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathwayQ24317317
EEA1 links PI(3)K function to Rab5 regulation of endosome fusionQ24322668
Deviant expression of Rab5 on phagosomes containing the intracellular pathogens Mycobacterium tuberculosis and Legionella pneumophila is associated with altered phagosomal fateQ24548766
Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectorsQ24645159
Structure and function of interacting IcmR-IcmQ domains from a type IVb secretion system in Legionella pneumophilaQ24649157
The phagosome proteome: insight into phagosome functionsQ24674883
Isolation of Legionella longbeachae serogroup 1 from potting mixesQ24676045
Legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 protein familyQ24677004
Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunityQ25257710
Crystal structure of Mip, a prolylisomerase from Legionella pneumophilaQ27634457
Crystal structure of a Legionella pneumophila ecto -triphosphate diphosphohydrolase, a structural and functional homolog of the eukaryotic NTPDasesQ27659876
Functional analysis of the multi-copper oxidase from Legionella pneumophilaQ45770773
Mip protein of Legionella pneumophila exhibits peptidyl-prolyl-cis/trans isomerase (PPlase) activityQ45771206
Electron microscopic examination of the inflammatory response to Legionella pneumophila in guinea pigs.Q46207200
SpoT governs Legionella pneumophila differentiation in host macrophagesQ46223959
Natural resistance to infection with Legionella pneumophila: chromosomal localization of the Lgn1 susceptibility geneQ46270718
Collagen binding protein Mip enables Legionella pneumophila to transmigrate through a barrier of NCI-H292 lung epithelial cells and extracellular matrixQ46300643
The prepilin peptidase is required for protein secretion by and the virulence of the intracellular pathogen Legionella pneumophilaQ46308706
Grouping of 20 reference strains of Legionella species by the growth ability within mouse and guinea pig macrophagesQ46520002
A mutation in an ompR-like gene on a Legionella longbeachae serogroup 1 plasmid attenuates virulenceQ46811836
Phagosomal acidification is not a prerequisite for intracellular multiplication of Legionella pneumophila in human monocytesQ47677295
Coxiella burnetii express type IV secretion system proteins that function similarly to components of the Legionella pneumophila Dot/Icm systemQ47725210
Legionella reveal dendritic cell functions that facilitate selection of antigens for MHC class II presentationQ47815851
A putative twin-arginine translocation pathway in Legionella pneumophila.Q47821431
Conjugative transfer by the virulence system of Legionella pneumophilaQ48040136
Identification and characterization of a new conjugation/type IVA secretion system (trb/tra) of Legionella pneumophila Corby localized on two mobile genomic islandsQ48077439
The Legionella IcmS-IcmW protein complex is important for Dot/Icm-mediated protein translocation.Q48153816
Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophilaQ48269403
Description of a putative type I secretion system in Legionella pneumophilaQ50101894
Siderophore activity among members of the Legionella genus.Q51611156
Role of interferon-gamma in inflammatory responses in murine respiratory infection with Legionella pneumophila.Q51725569
Direct demonstration and isolation of Legionella pneumophila (serogroup 1) from bathroom water specimens in a hotel.Q53049204
Induction of protective immunity by Legionella pneumophila flagellum in an A/J mouse model.Q53851473
Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila.Q53944716
Effects of an isogenic Zn-metalloprotease-deficient mutant of Legionella pneumophila in a guinea-pig pneumonia model.Q54203587
Phagocytosis of the Legionnaires' disease bacterium (Legionella pneumophila) occurs by a novel mechanism: engulfment within a pseudopod coil.Q54228644
Targeting eEF1A by a Legionella pneumophila effector leads to inhibition of protein synthesis and induction of host stress responseQ34257036
Immunophilins: structure-function relationship and possible role in microbial pathogenicityQ34292797
Relationship between endosomes and lysosomesQ34332410
lbtA and lbtB are required for production of the Legionella pneumophila siderophore legiobactinQ34353950
Pneumonia associated with HIV infectionQ34398368
The NOD: a signaling module that regulates apoptosis and host defense against pathogensQ34405567
Type II secretion: a protein secretion system for all seasonsQ34458508
A community-wide outbreak of legionnaires disease linked to industrial cooling towers--how far can contaminated aerosols spread?Q34472270
Identification of Legionella pneumophila-specific genes by genomic subtractive hybridization with Legionella micdadei and identification of lpnE, a gene required for efficient host cell entryQ34491737
Growth of Legionella pneumophila in Acanthamoeba castellanii enhances invasion.Q34532981
Human and guinea pig immune responses to Legionella pneumophila protein antigens OmpS and Hsp60.Q34534352
Bacterial interactions with the autophagic pathwayQ34539331
Legionella effectors that promote nonlytic release from protozoaQ34545894
Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf.Q34567184
A live avirulent mutant Legionella pneumophila vaccine induces protective immunity against lethal aerosol challengeQ34567957
Planktonic replication is essential for biofilm formation by Legionella pneumophila in a complex medium under static and dynamic flow conditionsQ34570406
Iron acquisition by Legionella pneumophilaQ34593124
Interaction between the legionnaires' disease bacterium (Legionella pneumophila) and human alveolar macrophages. Influence of antibody, lymphokines, and hydrocortisoneQ34613387
Members of a Legionella pneumophila family of proteins with ExoU (phospholipase A) active sites are translocated to target cellsQ34680988
How does Legionella pneumophila exit the host cell?Q34712599
Interaction of Legionella pneumophila with Acanthamoeba castellanii: uptake by coiling phagocytosis and inhibition of phagosome-lysosome fusionQ34731994
The phagosome containing Legionella pneumophila within the protozoan Hartmannella vermiformis is surrounded by the rough endoplasmic reticulumQ34734516
The TPR snap helix: a novel protein repeat motif from mitosis to transcriptionQ34840242
A type II secreted RNase of Legionella pneumophila facilitates optimal intracellular infection of Hartmannella vermiformisQ34953095
High-resolution genetic and physical map of the Lgn1 interval in C57BL/6J implicates Naip2 or Naip5 in Legionella pneumophila pathogenesisQ35028621
Autophagy is an immediate macrophage response to Legionella pneumophilaQ35060246
Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infectionQ35060264
Legionella pneumophila Mip, a surface-exposed peptidylproline cis-trans-isomerase, promotes the presence of phospholipase C-like activity in culture supernatantsQ35073681
A Legionella pneumophila gene encoding a species-specific surface protein potentiates initiation of intracellular infectionQ35094500
DNA sequence of mip, a Legionella pneumophila gene associated with macrophage infectivityQ35094542
Identification of mip-like genes in the genus LegionellaQ35103931
Legionella pneumophila glucosyltransferase inhibits host elongation factor 1A.Q35130836
Legionella pneumophila serogroup 1 strain Paris: endemic distribution throughout FranceQ35155683
A Legionella pneumophila-translocated substrate that is required for growth within macrophages and protection from host cell deathQ35161315
Toll-like receptor 4 is not involved in host defense against pulmonary Legionella pneumophila infection in a mouse modelQ39172615
The Legionella pneumophila rpoS gene is required for growth within Acanthamoeba castellaniiQ39496795
Discovery of a nonclassical siderophore, legiobactin, produced by strains of Legionella pneumophilaQ39498823
Activation of caspase 3 during Legionella pneumophila-induced apoptosis.Q39512039
Secreted enzymatic activities of wild-type and pilD-deficient Legionella pneumophilaQ39514957
Identification of Legionella pneumophila genes important for infection of amoebas by signature-tagged mutagenesisQ39518358
Phagocytosis of wild-type Legionella pneumophila occurs through a wortmannin-insensitive pathwayQ39521625
Serum cytokines in patients with Legionella pneumonia: relative predominance of Th1-type cytokinesQ39552195
Sequence-based classification scheme for the genus Legionella targeting the mip geneQ39553997
The Legionella pneumophila icmGCDJBF genes are required for killing of human macrophagesQ39571241
The Legionella autoinducer synthase LqsA produces an alpha-hydroxyketone signaling moleculeQ39600517
Legionella pneumophila contains a type II general secretion pathway required for growth in amoebae as well as for secretion of the Msp proteaseQ39613138
icmT is essential for pore formation-mediated egress of Legionella pneumophila from mammalian and protozoan cells.Q39653596
Intracellular growth of Legionella pneumophila gives rise to a differentiated form dissimilar to stationary-phase formsQ39663154
Characterization of a Legionella pneumophila relA insertion mutant and toles of RelA and RpoS in virulence gene expression.Q39678018
Ultrastructural analysis of differentiation in Legionella pneumophilaQ39680837
The autoinducer synthase LqsA and putative sensor kinase LqsS regulate phagocyte interactions, extracellular filaments and a genomic island of Legionella pneumophilaQ39740927
Functional similarities between the icm/dot pathogenesis systems of Coxiella burnetii and Legionella pneumophilaQ39776740
Identification of CpxR as a positive regulator of icm and dot virulence genes of Legionella pneumophilaQ39794022
Influence of iron-limited continuous culture on physiology and virulence of Legionella pneumophilaQ39823331
Influence of site specifically altered Mip proteins on intracellular survival of Legionella pneumophila in eukaryotic cellsQ39823589
Temporal resolution of two-tracked NF-kappaB activation by Legionella pneumophilaQ39830075
A Legionella effector acquired from protozoa is involved in sphingolipids metabolism and is targeted to the host cell mitochondria.Q39852238
Relationship between Legionella pneumophila and Acanthamoeba polyphaga: physiological status and susceptibility to chemical inactivationQ39894381
Rab1 guanine nucleotide exchange factor SidM is a major phosphatidylinositol 4-phosphate-binding effector protein of Legionella pneumophila.Q39903653
The inositol polyphosphate 5-phosphatase OCRL1 restricts intracellular growth of Legionella, localizes to the replicative vacuole and binds to the bacterial effector LpnE.Q39914102
Influence of temperature and plumbing material selection on biofilm formation and growth of Legionella pneumophila in a model potable water system containing complex microbial flora.Q39914857
Large-scale identification of Legionella pneumophila Dot/Icm substrates that modulate host cell vesicle trafficking pathwaysQ39915159
The PmrA/PmrB two-component system of Legionella pneumophila is a global regulator required for intracellular replication within macrophages and protozoaQ39927528
IFNbeta responses induced by intracellular bacteria or cytosolic DNA in different human cells do not require ZBP1 (DLM-1/DAI).Q39943290
Legionella pneumophila proteins that regulate Rab1 membrane cyclingQ40064228
Modulation of ubiquitin dynamics and suppression of DALIS formation by the Legionella pneumophila Dot/Icm systemQ40068268
Ecological distribution of Legionella pneumophila.Q40079072
Differential 2-D protein gel electrophoresis analysis of Legionella pneumophila wild type and Tat secretion mutantsQ40088858
The Legionella pneumophila response regulator LqsR promotes host cell interactions as an element of the virulence regulatory network controlled by RpoS and LetA.Q40110647
A bacterial ecto-triphosphate diphosphohydrolase similar to human CD39 is essential for intracellular multiplication of Legionella pneumophilaQ40153860
The response regulator PmrA is a major regulator of the icm/dot type IV secretion system in Legionella pneumophila and Coxiella burnetiiQ40170771
Detection of mip gene by PCR for diagnosis of Legionnaires' disease.Q40181319
Charcoal-yeast extract agar: primary isolation medium for Legionella pneumophilaQ40228948
Amino acid requirements of Legionella pneumophilaQ40229959
Rab proteins as membrane organizersQ27860861
Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cellsQ28116211
Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusionQ28141271
Subunit structure of a mammalian ER/Golgi SNARE complexQ28141448
X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modesQ28189754
Rab1 interaction with a GM130 effector complex regulates COPII vesicle cis--Golgi tetheringQ28210212
The LetA-RsmYZ-CsrA regulatory cascade, together with RpoS and PmrA, post-transcriptionally regulates stationary phase activation of Legionella pneumophila Icm/Dot effectorsQ28243105
A bifunctional bacterial protein links GDI displacement to Rab1 activationQ28253847
Legionella pneumophila induces IFNbeta in lung epithelial cells via IPS-1 and IRF3, which also control bacterial replicationQ28264386
Early trafficking and intracellular replication of Legionella longbeachaea within an ER-derived late endosome-like phagosomeQ28288972
Proteome analysis of Legionella vacuoles purified by magnetic immunoseparation reveals secretory and endosomal GTPasesQ28299601
The Legionella pneumophila IcmSW complex interacts with multiple Dot/Icm effectors to facilitate type IV translocationQ28471800
Type IV secretion-dependent activation of host MAP kinases induces an increased proinflammatory cytokine response to Legionella pneumophilaQ28474072
Chemical genetics reveals bacterial and host cell functions critical for type IV effector translocation by Legionella pneumophilaQ28475654
Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functionsQ28485639
Studies on the mechanisms of autophagy: formation of the autophagic vacuoleQ28565520
Type I IFN protects permissive macrophages from Legionella pneumophila infection through an IFN-gamma-independent pathwayQ28585517
Surface-associated hsp60 chaperonin of Legionella pneumophila mediates invasion in a HeLa cell modelQ28905118
Recognition of cytosolic DNA activates an IRF3-dependent innate immune responseQ29616156
A rab protein is required for the assembly of SNARE complexes in the docking of transport vesiclesQ29620271
Adherence of Legionella pneumophila to U-937 cells, guinea-pig alveolar macrophages, and MRC-5 cells by a novel, complement-independent binding mechanismQ30420327
Caenorhabditis is a metazoan host for LegionellaQ30431794
Structural considerations of the snake venom metalloproteinases, key members of the M12 reprolysin family of metalloproteinases.Q30436990
Packaging of live Legionella pneumophila into pellets expelled by Tetrahymena spp. does not require bacterial replication and depends on a Dot/Icm-mediated survival mechanismQ30441290
Interaction of Legionella micdadei with human monocytesQ30451163
Identification of novel loci involved in entry by Legionella pneumophilaQ30877506
Identification of host cytosolic sensors and bacterial factors regulating the type I interferon response to Legionella pneumophilaQ30912277
Temporal pore formation-mediated egress from macrophages and alveolar epithelial cells by Legionella pneumophilaQ30944261
Quantitative real-time Legionella PCR for environmental water samples: data interpretation.Q31036223
The C-terminus of IcmT is essential for pore formation and for intracellular trafficking of Legionella pneumophila within Acanthamoeba polyphagaQ32068477
Cloning and characterization of the gene encoding the major cell-associated phospholipase A of Legionella pneumophila, plaB, exhibiting hemolytic activityQ33202129
Cytochrome c maturation proteins are critical for in vivo growth of Legionella pneumophilaQ33209856
A yeast genetic system for the identification and characterization of substrate proteins transferred into host cells by the Legionella pneumophila Dot/Icm systemQ33214421
RNA interference analysis of Legionella in Drosophila cells: exploitation of early secretory apparatus dynamicsQ33241705
Transient transgenic expression of gamma interferon promotes Legionella pneumophila clearance in immunocompetent hostsQ34009414
Involvement of fractalkine/CX3CL1 expression by dendritic cells in the enhancement of host immunity against Legionella pneumophilaQ34033832
Components of the Legionella pneumophila flagellar regulon contribute to multiple virulence traits, including lysosome avoidance and macrophage deathQ34034097
Legionnaires' disease: description of an epidemic of pneumoniaQ34049676
Production of respirable vesicles containing live Legionella pneumophila cells by two Acanthamoeba spp.Q34071145
The DotA protein from Legionella pneumophila is secreted by a novel process that requires the Dot/Icm transporterQ34083176
The cytochrome c maturation locus of Legionella pneumophila promotes iron assimilation and intracellular infection and contains a strain-specific insertion sequence elementQ34120954
Legionella pneumophila feoAB promotes ferrous iron uptake and intracellular infectionQ34132560
Distribution of Legionella species and serogroups isolated by culture in patients with sporadic community-acquired legionellosis: an international collaborative surveyQ34136087
Infection due to Legionella species other than L. pneumophilaQ34152383
Legionnaires' disease: isolation of a bacterium and demonstration of its role in other respiratory diseaseQ34175679
Characterization of the gene encoding the major secreted lysophospholipase A of Legionella pneumophila and its role in detoxification of lysophosphatidylcholineQ34185826
A 65-kilobase pathogenicity island is unique to Philadelphia-1 strains of Legionella pneumophilaQ35162381
Resuscitation of viable but nonculturable Legionella pneumophila Philadelphia JR32 by Acanthamoeba castellaniiQ35201201
In vivo regulation of replicative Legionella pneumophila lung infection by endogenous tumor necrosis factor alpha and nitric oxideQ35433678
Association of Legionella pneumophila with the macrophage endoplasmic reticulumQ35438605
Legionella pneumophila mutants that are defective for iron acquisition and assimilation and intracellular infectionQ35470009
Reduced interferon-gamma release in patients recovered from Legionnaires' diseaseQ35535418
Legionella pneumophila type II secretome reveals unique exoproteins and a chitinase that promotes bacterial persistence in the lungQ35539830
Clinical and environmental distributions of Legionella strains in France are differentQ35552937
Multiple substrates of the Legionella pneumophila Dot/Icm system identified by interbacterial protein transfer.Q35554474
Characterization of a new region required for macrophage killing by Legionella pneumophilaQ35559956
Role of Toll-like receptor 9 in Legionella pneumophila-induced interleukin-12 p40 production in bone marrow-derived dendritic cells and macrophages from permissive and nonpermissive miceQ35689020
Environmental mimics and the Lvh type IVA secretion system contribute to virulence-related phenotypes of Legionella pneumophilaQ35689293
Macrophage permissiveness for Legionella pneumophila growth modulated by ironQ35773236
Cytotoxicity of extracellular Legionella pneumophilaQ35781014
Vaccination with Legionella pneumophila membranes induces cell-mediated and protective immunity in a guinea pig model of Legionnaires' disease. Protective immunity independent of the major secretory protein of Legionella pneumophilaQ35820423
Replicative Legionella pneumophila lung infection in intratracheally inoculated A/J mice. A murine model of human Legionnaires' disease.Q35834271
Host cell killing and bacterial conjugation require overlapping sets of genes within a 22-kb region of the Legionella pneumophila genome.Q35880737
Host-dependent trigger of caspases and apoptosis by Legionella pneumophilaQ35913392
The secreted pyomelanin pigment of Legionella pneumophila confers ferric reductase activityQ35949713
Dictyostelium as host model for pathogenesisQ36023742
Survival of coliforms and bacterial pathogens within protozoa during chlorinationQ36096632
Legionella pneumophila inhibits acidification of its phagosome in human monocytesQ36212159
NF-kappaB translocation prevents host cell death after low-dose challenge by Legionella pneumophila.Q36228869
Legionella pneumophila type II protein secretion promotes virulence in the A/J mouse model of Legionnaires' disease pneumoniaQ36229196
A comparison of virulence of two strains of Legionella pneumophila based on experimental aerosol infection of guinea-pigsQ36250179
Aerosol infection of animals with strains of Legionella pneumophila of different virulence: comparison with intraperitoneal and intranasal routes of infectionQ36258311
Intermediary metabolism in Legionella pneumophila: utilization of amino acids and other compounds as energy sourcesQ36329866
The Legionnaires' disease bacterium (Legionella pneumophila) inhibits phagosome-lysosome fusion in human monocytesQ36348251
Formation of a novel phagosome by the Legionnaires' disease bacterium (Legionella pneumophila) in human monocytesQ36349063
Vaccination with the major secretory protein of Legionella pneumophila induces cell-mediated and protective immunity in a guinea pig model of Legionnaires' diseaseQ36356234
Legionella pneumophila replication vacuoles mature into acidic, endocytic organellesQ36369087
Legionella pneumophila is internalized by a macropinocytotic uptake pathway controlled by the Dot/Icm system and the mouse Lgn1 locusQ36369590
A Common Dominant TLR5 Stop Codon Polymorphism Abolishes Flagellin Signaling and Is Associated with Susceptibility to Legionnaires' DiseaseQ36371497
Identification of a gene that affects the efficiency of host cell infection by Legionella pneumophila in a temperature-dependent fashionQ36375709
Legionella subvert the functions of Rab1 and Sec22b to create a replicative organelle.Q36399499
The type II secretion system of Legionella pneumophila elaborates two aminopeptidases, as well as a metalloprotease that contributes to differential infection among protozoan hosts.Q36430591
Multigenome analysis identifies a worldwide distributed epidemic Legionella pneumophila clone that emerged within a highly diverse speciesQ36484295
Nonpneumonic, Short-Incubation-Period Legionellosis (Pontiac Fever) in Men Who Cleaned a Steam Turbine CondenserQ36522724
Inflammasome adaptors and sensors: intracellular regulators of infection and inflammationQ36691082
Enzymatic properties of an ecto-nucleoside triphosphate diphosphohydrolase from Legionella pneumophila: substrate specificity and requirement for virulenceQ36741587
Significant role for ladC in initiation of Legionella pneumophila infection.Q36747109
Toll-like receptor 9 regulates the lung macrophage phenotype and host immunity in murine pneumonia caused by Legionella pneumophilaQ36747187
Legionella pathogenicity: genome structure, regulatory networks and the host cell responseQ36805537
Legionella pneumophila inhibits protein synthesis in Chinese hamster ovary cellsQ36959611
Legionella pneumophila EnhC is required for efficient replication in tumour necrosis factor alpha-stimulated macrophagesQ36964166
Passage through Tetrahymena tropicalis triggers a rapid morphological differentiation in Legionella pneumophilaQ36974544
Cell-mediated Immunity in Legionnaires' DiseaseQ36989852
Manipulation of rab GTPase function by intracellular bacterial pathogensQ37026524
Legionella pneumophila mip gene potentiates intracellular infection of protozoa and human macrophagesQ37048382
The manifold phospholipases A of Legionella pneumophila - identification, export, regulation, and their link to bacterial virulenceQ37051779
Approaching the degradome in idiopathic pulmonary fibrosisQ37061287
Clinical features of two cases of Legionnaires' disease with persistence of Legionella urinary antigen excretionQ37073371
The Coxiella burnetii ankyrin repeat domain-containing protein family is heterogeneous, with C-terminal truncations that influence Dot/Icm-mediated secretionQ37232712
Identification of a Legionella pneumophila locus required for intracellular multiplication in human macrophagesQ37246061
Purification of Legiobactin and importance of this siderophore in lung infection by Legionella pneumophilaQ37256486
A Legionella type IV effector activates the NF-kappaB pathway by phosphorylating the IkappaB family of inhibitorsQ37310577
The Legionella pneumophila replication vacuole: making a cosy niche inside host cellsQ37326393
Legionnaires' disease at a Dutch flower show: prognostic factors and impact of therapyQ37334472
Amino acid requirements for Legionella pneumophila growthQ37335773
The ubiquitylation machinery of the endoplasmic reticulumQ37424805
Interferons direct an effective innate response to Legionella pneumophila infectionQ37431639
Legionella pneumophila: population genetics, phylogeny and genomicsQ37486976
Modulation of caspases and their non-apoptotic functions by Legionella pneumophilaQ37623015
The phagosomal nutrient transporter (Pht) familyQ37858334
Incidence of community-acquired pneumonia requiring hospitalization. Results of a population-based active surveillance Study in Ohio. The Community-Based Pneumonia Incidence Study GroupQ37882238
Legionella pneumophila exploits PI(4)P to anchor secreted effector proteins to the replicative vacuoleQ33243973
Sel1 repeat protein LpnE is a Legionella pneumophila virulence determinant that influences vacuolar traffickingQ33300200
Proteomic characterization of the whole secretome of Legionella pneumophila and functional analysis of outer membrane vesiclesQ33318183
Legionella eukaryotic-like type IV substrates interfere with organelle traffickingQ33356625
Synergistic contribution of the Legionella pneumophila lqs genes to pathogen-host interactionsQ33370857
Non-opsonic phagocytosis of Legionella pneumophila by macrophages is mediated by phosphatidylinositol 3-kinaseQ33373341
A Legionella pneumophila effector protein encoded in a region of genomic plasticity binds to Dot/Icm-modified vacuolesQ33402465
Evidence that the intra-amoebal Legionella drancourtii acquired a sterol reductase gene from eukaryotesQ33423229
Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infectionQ33426360
Rapid pathogen-induced apoptosis: a mechanism used by dendritic cells to limit intracellular replication of Legionella pneumophilaQ33466758
Genome-scale identification of Legionella pneumophila effectors using a machine learning approachQ33480961
Mouse macrophages are permissive to motile Legionella species that fail to trigger pyroptosisQ33557896
Identification and subcellular localization of the Legionella pneumophila IcmX protein: a factor essential for establishment of a replicative organelle in eukaryotic host cellsQ33596507
Mycobacterium tuberculosis and Legionella pneumophila phagosomes exhibit arrested maturation despite acquisition of Rab7.Q33599349
Identification of Legionella pneumophila genes required for growth within and killing of human macrophagesQ33617859
In vivo regulation of replicative Legionella pneumophila lung infection by endogenous interleukin-12.Q33747346
Identification of linked Legionella pneumophila genes essential for intracellular growth and evasion of the endocytic pathwayQ33751274
Expression of Legionella pneumophila virulence traits in response to growth conditionsQ33755799
A C-terminal translocation signal required for Dot/Icm-dependent delivery of the Legionella RalF protein to host cellsQ33756497
Characterization of the major secreted zinc metalloprotease- dependent glycerophospholipid:cholesterol acyltransferase, PlaC, of Legionella pneumophilaQ33769080
Preliminary report on the pathogenicity of Legionella pneumophila for freshwater and soil amoebaeQ33848527
Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' diseaseQ33851201
Major cytoplasmic membrane protein of Legionella pneumophila, a genus common antigen and member of the hsp 60 family of heat shock proteins, induces protective immunity in a guinea pig model of Legionnaires' diseaseQ33891710
The phagosomal transporter A couples threonine acquisition to differentiation and replication of Legionella pneumophila in macrophagesQ33895970
The Legionella pneumophila major secretory protein, a protease, is not required for intracellular growth or cell killing.Q33924228
Pathogen effector protein screening in yeast identifies Legionella factors that interfere with membrane traffickingQ33935172
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cellsQ33987714
Intracellular growth in Acanthamoeba castellanii affects monocyte entry mechanisms and enhances virulence of Legionella pneumophila.Q34001674
The Legionella pneumophila iraAB locus is required for iron assimilation, intracellular infection, and virulenceQ34003442
Immunomodulatory role of endogenous interleukin-18 in gamma interferon-mediated resolution of replicative Legionella pneumophila lung infectionQ34005119
Legionella pneumophila major acid phosphatase and its role in intracellular infectionQ34005553
Legionella pneumophila entry gene rtxA is involved in virulenceQ34005732
Type II protein secretion is a subset of the PilD-dependent processes that facilitate intracellular infection by Legionella pneumophilaQ34006686
Comparison of virulence of Legionella longbeachae strains in guinea pigs and U937 macrophage-like cellsQ34008830
Growth-phase-dependent mobility of the lvh-encoding region in Legionella pneumophila strain Paris.Q54568001
Low mannose-binding lectin complement activation function is associated with predisposition to Legionnaires' disease.Q55043718
Evidence of horizontal gene transfer between amoeba and bacteriaQ56583000
MyD88-dependent IFN-gamma production by NK cells is key for control of Legionella pneumophila infectionQ57217265
The Genomic Sequence of the Accidental Pathogen Legionella pneumophilaQ57265781
Experimental Legionella longbeachae infection in intratracheally inoculated miceQ57818988
Virulence strategies for infecting phagocytes deduced from the in vivo transcriptional program of Legionella pneumophilaQ57954214
Domain Motions of the Mip Protein fromLegionella pneumophila†,‡Q60633090
The Legionella pneumophila effector protein DrrA is a Rab1 guanine nucleotide-exchange factorQ60648871
The Legionella pneumophila GacA homolog (LetA) is involved in the regulation of icm virulence genes and is required for intracellular multiplication in Acanthamoeba castellaniiQ62673789
Streptococcus pneumoniae and Legionella pneumophila pneumonia in HIV-infected patientsQ64133516
Transcriptional regulation of the macrophage‐induced gene ( gspA ) of Legionella pneumophila and phenotypic characterization of a null mutantQ64138960
In vitro secretion kinetics of proteins from Legionella pneumophila in comparison to proteins from non-pneumophila speciesQ64449539
Analysis of proteins and respiratory cells obtained from human lungs by bronchial lavageQ68787625
Cytolytic activity of human peripheral blood leukocytes against Legionella pneumophila-infected monocytes: characterization of the effector cell and augmentation by interleukin 2Q68823068
Virulence associated ingestion of Legionella pneumophila by HeLa cellsQ68843249
Immunogenicity and adjuvanticity of lipopolysaccharide from Legionella pneumophilaQ69735046
Comparison of multiplex PCR and culture for detection of Legionellae in cooling tower water samplesQ71075328
A homodimer represents an active species of the peptidyl‐prolyl cis/trans isomerase FKBP25mem from Legionella pneumophilaQ71650108
Lgn1, a gene that determines susceptibility to Legionella pneumophila, maps to mouse chromosome 13Q71867211
The rickettsia-like organisms TATLOCK (1943) and HEBA (1959): bacteria phenotypically similar to but genetically distinct from Legionella pneumophila and the WIGA bacteriumQ72124525
Interferon-gamma (IFN-gamma) production by human T lymphocytes upon Legionella pneumophila stimulation in vitroQ72388704
Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophilaQ72951041
Investigation of mechanisms involved in phagocytosis of Legionella pneumophila by human cellsQ73087341
The response regulator LetA regulates the stationary-phase stress response in Legionella pneumophila and is required for efficient infection of Acanthamoeba castellaniiQ73087352
Heterogeneity in intracellular replication and cytopathogenicity of Legionella pneumophila and Legionella micdadei in mammalian and protozoan cellsQ73141923
The Legionella pneumophila LidA protein: a translocated substrate of the Dot/Icm system associated with maintenance of bacterial integrityQ73215694
LegionellosisQ73648619
Aberrantly low transferrin receptor expression on human monocytes is associated with nonpermissiveness for Legionella pneumophila growthQ73670483
Entry and intracellular localization of Legionella dumoffii in Vero cellsQ74237677
Legionella pneumophila infection in intratracheally inoculated T cell-depleted or -nondepleted A/J miceQ74463677
Legionella and immunosuppressionQ74714360
Co-ordination of legionella pneumophila virulence with entry into stationary phase by ppGppQ78127783
Legionella pneumophila induces apoptosis via the mitochondrial death pathwayQ78504758
Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sitesQ78559396
Identification of the core transmembrane complex of the Legionella Dot/Icm type IV secretion systemQ79239016
Legionella pneumophila CsrA is a pivotal repressor of transmission traits and activator of replicationQ79293753
Macroautophagy is dispensable for intracellular replication of Legionella pneumophila in Dictyostelium discoideumQ79338625
Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathwaysQ80345055
Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophilaQ81550394
Activated macrophages infected with Legionella inhibit T cells by means of MyD88-dependent production of prostaglandinsQ81598360
Mannose-binding lectin genotypes in susceptibility to community-acquired pneumoniaQ81670395
Legionella pneumophila Philadelphia-1 tatB and tatC affect intracellular replication and biofilm formationQ81729935
The Legionella pneumophila phosphatidylinositol-4 phosphate-binding type IV substrate SidC recruits endoplasmic reticulum vesicles to a replication-permissive vacuoleQ81730696
TNF receptor 1 and 2 contribute in different ways to resistance to Legionella pneumophila-induced mortality in miceQ82220345
The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infectionQ82412798
Deficient mannose-binding lectin-mediated complement activation despite mannose-binding lectin-sufficient genotypes in an outbreak of Legionella pneumophila pneumoniaQ82919441
Myeloid differentiation primary response gene (88)- and toll-like receptor 2-deficient mice are susceptible to infection with aerosolized Legionella pneumophilaQ83352250
Cytolytic and phospholipase C activity in Legionella speciesQ93618103
Chemically defined medium for Legionella pneumophila growthQ40231695
Metal requirements of Legionella pneumophila.Q40232360
Anti-apoptotic signalling by the Dot/Icm secretion system of L. pneumophilaQ40243451
Targeting of host Rab GTPase function by the intravacuolar pathogen Legionella pneumophila.Q40258153
Involvement of tumor necrosis factor alpha in intracellular multiplication of Legionella pneumophila in human monocytes.Q40269694
Attachment and fusion of endoplasmic reticulum with vacuoles containing Legionella pneumophilaQ40293289
Legionella pneumophila - Host Interactions: Insights Gained from Comparative Genomics and Cell BiologyQ40381939
A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomesQ40754890
Legionella pneumophila replication vacuole formation involves rapid recruitment of proteins of the early secretory systemQ40764000
Icm/dot-dependent upregulation of phagocytosis by Legionella pneumophila.Q40766603
Pontiac fever associated with a whirlpool spa.Q40822943
Localization of Legionella bacteria within ribosome-studded phagosomes is not restricted to Legionella pneumophilaQ40847668
Experimental transmission of legionnaires' disease by exposure to aerosols of Legionella pneumophilaQ40849203
The LetE protein enhances expression of multiple LetA/LetS-dependent transmission traits by Legionella pneumophilaQ40882993
The type II protein secretion system of Legionella pneumophila promotes growth at low temperaturesQ40902083
Isolation of the Legionnaires' Disease Bacterium from Environmental SamplesQ41029667
Two small ncRNAs jointly govern virulence and transmission in Legionella pneumophilaQ41210826
Loss of RNase R induces competence development in Legionella pneumophila.Q41365469
Interferon-gamma-activated human monocytes inhibit the intracellular multiplication of Legionella pneumophilaQ41381283
Altered intracellular targeting properties associated with mutations in the Legionella pneumophila dotA geneQ41432231
The Legionella pneumophila icm locus: a set of genes required for intracellular multiplication in human macrophagesQ41432238
Classification of the Legionnaires' disease bacterium: Legionella pneumophila, genus novum, species nova, of the family Legionellaceae, familia novaQ41536915
Survival of the Legionnaires' Disease Bacterium in WaterQ41536923
Immunologic protection against the Legionnaires' disease bacterium in the AKR/J mouseQ41536939
Opsonin-independent adherence and intracellular development of Legionella pneumophila within U-937 cells.Q41544215
Intracellular multiplication of Legionella pneumophila in HL-60 cells differentiated by 1,25-dihydroxyvitamin D3 and the effect of interferon gammaQ41544700
Endosomal and secretory markers of the Legionella-containing vacuoleQ41787047
Importance of type II secretion for survival of Legionella pneumophila in tap water and in amoebae at low temperaturesQ41833606
MyD88-dependent responses involving toll-like receptor 2 are important for protection and clearance of Legionella pneumophila in a mouse model of Legionnaires' diseaseQ41838511
Characterization of avirulent mutant Legionella pneumophila that survive but do not multiply within human monocytesQ41869148
LidA, a translocated substrate of the Legionella pneumophila type IV secretion system, interferes with the early secretory pathwayQ41897005
Interaction ofL. pneumophilaand a free living amoeba (Acanthamoeba palestinensis)Q41942351
Distribution of Legionella longbeachae serogroup 1 and other legionellae in potting soils in AustraliaQ41995902
Legionella pneumophila secretes an endoglucanase that belongs to the family-5 of glycosyl hydrolases and is dependent upon type II secretionQ41998921
The Legionella pneumophila tatB gene facilitates secretion of phospholipase C, growth under iron-limiting conditions, and intracellular infectionQ42010509
Region of elongation factor 1A1 involved in substrate recognition by Legionella pneumophila glucosyltransferase Lgt1: identification of Lgt1 as a retaining glucosyltransferaseQ42023887
The response regulator CpxR directly regulates expression of several Legionella pneumophila icm/dot components as well as new translocated substrates.Q42032194
A Legionella pneumophila peptidyl-prolyl cis-trans isomerase present in culture supernatants is necessary for optimal growth at low temperaturesQ42094779
A Dot/Icm-translocated ankyrin protein of Legionella pneumophila is required for intracellular proliferation within human macrophages and protozoa.Q42175516
Multiple MyD88-dependent responses contribute to pulmonary clearance of Legionella pneumophilaQ42568936
The amoebal MAP kinase response to Legionella pneumophila is regulated by DupAQ42592086
cDNA cloning and the 5'genomic organization of Naip2, a candidate gene for murine Legionella resistanceQ42604410
The purified and recombinant Legionella pneumophila chaperonin alters mitochondrial trafficking and microfilament organizationQ42613097
Vaccination with the major secretory protein of Legionella induces humoral and cell-mediated immune responses and protective immunity across different serogroups of Legionella pneumophila and different species of LegionellaQ42616380
The transfer region of IncI1 plasmid R64: similarities between R64 tra and legionella icm/dot genesQ42623822
Pore formation triggered by Legionella spp. is an Nlrc4 inflammasome-dependent host cell response that precedes pyroptosisQ42910230
Mediators of lipid A modification, RNA degradation, and central intermediary metabolism facilitate the growth of Legionella pneumophila at low temperaturesQ42932913
Asc and Ipaf Inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophilaQ43127944
Surface translocation by Legionella pneumophila: a form of sliding motility that is dependent upon type II protein secretion.Q43173562
Role of biofilms in the survival of Legionella pneumophila in a model potable-water systemQ43349443
RpoS co-operates with other factors to induce Legionella pneumophila virulence in the stationary phaseQ43636755
How the parasitic bacterium Legionella pneumophila modifies its phagosome and transforms it into rough ER: implications for conversion of plasma membrane to the ER membraneQ43855825
A two-component regulator induces the transmission phenotype of stationary-phase Legionella pneumophila.Q43967545
Legionella pneumophila genes that encode lipase and phospholipase C activities.Q44052663
Engulfment of the Philadelphia strain of Legionella pneumophila within pseudopod coils in human phagocytes. Comparison with other Legionella strains and species.Q44478549
Evidence for pore-forming ability by Legionella pneumophilaQ44534416
IcmR-regulated membrane insertion and efflux by the Legionella pneumophila IcmQ proteinQ44660931
Activation of caspase-3 by the Dot/Icm virulence system is essential for arrested biogenesis of the Legionella-containing phagosomeQ44695321
Clonal population structure of Legionella pneumophila inferred from allelic profiling.Q44833675
Intracellular multiplication of Legionella pneumophila depends on host cell amino acid transporter SLC1A5.Q45273584
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectLegionella pneumophilaQ147885
pathogenesisQ372016
P1104number of pages25
P304page(s)274-298
P577publication date2010-04-01
P1433published inClinical Microbiology ReviewsQ5133777
P1476titleMolecular pathogenesis of infections caused by Legionella pneumophila
P478volume23

Reverse relations

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Q38156244The natural alternative: protozoa as cellular models for Legionella infection
Q41727068The novel Legionella pneumophila type II secretion substrate NttC contributes to infection of amoebae Hartmannella vermiformis and Willaertia magna
Q35362525The surfactant of Legionella pneumophila Is secreted in a TolC-dependent manner and is antagonistic toward other Legionella species
Q54257153The α-hydroxyketone LAI-1 regulates motility, Lqs-dependent phosphorylation signalling and gene expression of Legionella pneumophila.
Q27679717TheLegionella pneumophila kaioperon is implicated in stress response and confers fitness in competitive environments
Q28468502Transcriptome Analysis of the Intracellular Facultative Pathogen Piscirickettsia salmonis: Expression of Putative Groups of Genes Associated with Virulence and Iron Metabolism
Q35755229Transcriptomic changes of Legionella pneumophila in water
Q39877074Two Cases of Hypophosphatemia with Increased Renal Phosphate Excretion in Legionella Pneumonia.
Q40164466Type II Secretion Substrates of Legionella pneumophila Translocate Out of the Pathogen-Occupied Vacuole via a Semipermeable Membrane
Q40092833Ubiquitin Chains Modified by the Bacterial Ligase SdeA Are Protected from Deubiquitinase Hydrolysis
Q41572903Updated Insight into the Physiological and Pathological Roles of the Retromer Complex
Q36173904Utility of PCR, Culture, and Antigen Detection Methods for Diagnosis of Legionellosis
Q36396778Virulence phenotypes of Legionella pneumophila associated with noncoding RNA lpr0035
Q51148471Virulence traits of environmental and clinical Legionella pneumophila MLVA genotypes.
Q39113393Whole-genome comparative analysis of the pathogen Piscirickettsia salmonis
Q36036849α-Hydroxyketone synthesis and sensing by Legionella and Vibrio

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