Targeting C-type lectin receptors: a high-carbohydrate diet for dendritic cells to improve cancer vaccines

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Targeting C-type lectin receptors: a high-carbohydrate diet for dendritic cells to improve cancer vaccines is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1189/JLB.5MR0217-059RR
P932PMC publication ID5597514
P698PubMed publication ID28729358

P50authorYvette van KooykQ29914012
Tanja D de GruijlQ90913412
Joke den HaanQ60250994
Dieke van DintherQ60252717
P2093author name stringRieneke van de Ven
Dorian A Stolk
P2860cites workAPCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motifQ22003753
Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granulesQ22011207
Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectinQ24315864
CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytesQ24320164
Molecular cloning and expression of cDNA encoding human macrophage C-type lectin. Its unique carbohydrate binding specificity for Tn antigenQ24321985
Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell developmentQ24645273
ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8alpha(+) dendritic cellsQ24672345
Dendritic-cell-associated C-type lectin 2 (DCAL-2) alters dendritic-cell maturation and cytokine productionQ24685926
Direct Delivery of Antigens to Dendritic Cells via Antibodies Specific for Endocytic Receptors as a Promising Strategy for Future TherapiesQ26752558
The development and maintenance of resident macrophagesQ26774975
Functional Specialization of Skin Dendritic Cell Subsets in Regulating T Cell ResponsesQ26777948
Adjuvant for vaccine immunotherapy of cancer--focusing on Toll-like receptor 2 and 3 agonists for safely enhancing antitumor immunityQ26782131
Immune Checkpoint Blockade in Cancer TherapyQ26830509
Tissue-resident macrophagesQ26991488
Antigen delivery to macrophages using liposomal nanoparticles targeting sialoadhesin/CD169Q27301034
Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell ImmunityQ27489852
Different cross-presentation pathways in steady-state and inflammatory dendritic cellsQ28115137
Sialoadhesin, a macrophage sialic acid binding receptor for haemopoietic cells with 17 immunoglobulin-like domainsQ28115533
Identification of mouse langerin/CD207 in Langerhans cells and some dendritic cells of lymphoid tissuesQ28214619
Structure and function of the spleenQ28264813
Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteriaQ28265610
The mannose receptorQ28274841
Development of human plasmacytoid dendritic cells depends on the combined action of the basic helix-loop-helix factor E2-2 and the Ets factor Spi-BQ28293931
Siglecs and their roles in the immune systemQ28294469
Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formationQ28393754
Porcine sialoadhesin (CD169/Siglec-1) is an endocytic receptor that allows targeted delivery of toxins and antigens to macrophagesQ28477167
Essential role for ICSBP in the in vivo development of murine CD8alpha + dendritic cellsQ28505356
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissuesQ28510383
Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cellsQ28591976
Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytesQ28592638
Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responsesQ28616569
EBI2-mediated bridging channel positioning supports splenic dendritic cell homeostasis and particulate antigen captureQ29347264
A Novel Human Cancer Vaccine Elicits Cellular Responses to the Tumor-Associated Antigen, Human Chorionic GonadotropinQ29391980
In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigensQ29615098
Differential antigen processing by dendritic cell subsets in vivoQ29615177
Taking dendritic cells into medicineQ29619243
Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophagesQ29620142
PD-1 blockade induces responses by inhibiting adaptive immune resistanceQ29620856
Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivoQ30080006
In vivo analysis of dendritic cell development and homeostasisQ30492687
Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonistQ30573156
Critical Role for CD103(+)/CD141(+) Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in MelanomaQ30843481
Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cellsQ30873503
Internalizing antibodies to the C-type lectins, L-SIGN and DC-SIGN, inhibit viral glycoprotein binding and deliver antigen to human dendritic cells for the induction of T cell responsesQ33229932
Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC networkQ33590503
Effective collaboration between marginal metallophilic macrophages and CD8+ dendritic cells in the generation of cytotoxic T cellsQ33591529
Induction and activation of human Th17 by targeting antigens to dendritic cells via dectin-1.Q33723950
The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8alpha+ dendritic cellsQ33902379
Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cellsQ33902421
Distribution and function of macrophage galactose-type C-type lectin 2 (MGL2/CD301b): efficient uptake and presentation of glycosylated antigens by dendritic cellsQ33911282
CD8(+) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo.Q33928441
High sensitivity of cancer exome-based CD8 T cell neo-antigen identificationQ33930588
Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIRQ34163004
Skin immune sentinels in health and diseaseQ34165173
Antigen targeting to dendritic cells combined with transient regulatory T cell inhibition results in long-term tumor regressionQ36060263
Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogenyQ36263627
Extrafollicular B cell activation by marginal zone dendritic cells drives T cell-dependent antibody responsesQ36278067
Blood-derived dermal langerin+ dendritic cells survey the skin in the steady stateQ36294401
Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cellsQ36333494
Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identifiedQ36367631
Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell toleranceQ36376611
In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccinationQ36402359
The BXH2 mutation in IRF8 differentially impairs dendritic cell subset development in the mouseQ36445813
A new synthetic TLR4 agonist, GLA, allows dendritic cells targeted with antigen to elicit Th1 T-cell immunity in vivoQ36452968
Immunomodulation of the melanoma sentinel lymph node: a novel adjuvant therapeutic optionQ36571695
Engineered lentivector targeting of dendritic cells for in vivo immunizationQ36629181
Characterisation of murine MICL (CLEC12A) and evidence for an endogenous ligandQ36725571
The multifaceted biology of plasmacytoid dendritic cellsQ36731249
Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursorsQ36775202
Local delivery of CpG-B and GM-CSF induces concerted activation of effector and regulatory T cells in the human melanoma sentinel lymph nodeQ36783070
Similar antigen cross-presentation capacity and phagocytic functions in all freshly isolated human lymphoid organ-resident dendritic cellsQ36822691
Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activationQ36835483
IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responsesQ36882237
Targeted cancer therapy: conferring specificity to cytotoxic drugsQ36912991
Dendritic-cell immunotherapy: from ex vivo loading to in vivo targetingQ36939901
The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancementQ36941087
CD141+ dendritic cells produce prominent amounts of IFN-α after dsRNA recognition and can be targeted via DEC-205 in humanized miceQ36945969
Distinct Transcriptional Programs Control Cross-Priming in Classical and Monocyte-Derived Dendritic CellsQ37086985
Peptide-loaded Langerhans cells, despite increased IL15 secretion and T-cell activation in vitro, elicit antitumor T-cell responses comparable to peptide-loaded monocyte-derived dendritic cells in vivo.Q37095794
Identification of a dendritic cell receptor that couples sensing of necrosis to immunityQ37164859
Targeting CLEC9A delivers antigen to human CD141(+) DC for CD4(+) and CD8(+)T cell recognitionQ37277188
CD301b⁺ dermal dendritic cells drive T helper 2 cell-mediated immunityQ37284012
Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and SpeciesQ37293474
Antibody and T cell responses of patients with adenocarcinoma immunized with mannan-MUC1 fusion proteinQ37375709
A novel peptide targeting Clec9a on dendritic cell for cancer immunotherapyQ37457907
Transcriptional Control of Dendritic Cell Development.Q37468541
Density of immunogenic antigens does not explain the presence or absence of the T-cell-inflamed tumor microenvironment in melanomaQ37473978
RAB43 facilitates cross-presentation of cell-associated antigens by CD8α+ dendritic cells.Q37500322
Human dendritic cells (DCs) are derived from distinct circulating precursors that are precommitted to become CD1c+ or CD141+ DCs.Q37500375
Human skin dendritic cells can be targeted in situ by intradermal injection of antibodies against lectin receptors.Q42106951
Langerin-expressing dendritic cells in human tissues are related to CD1c+ dendritic cells and distinct from Langerhans cells and CD141high XCR1+ dendritic cells.Q42108118
Origin of the lamina propria dendritic cell networkQ42117974
Dendritic cell-associated lectin 2 (DCAL2) defines a distinct CD8α- dendritic cell subsetQ42143775
Nanoparticle-mediated combinatorial targeting of multiple human dendritic cell (DC) subsets leads to enhanced T cell activation via IL-15-dependent DC crosstalk.Q42202638
Ex vivo generation of interstitial and Langerhans cell-like dendritic cell subset-based vaccines for hematological malignanciesQ42219829
In vivo targeting of human DC-SIGN drastically enhances CD8⁺ T-cell-mediated protective immunityQ42258180
Cationic amphiphile with shikimic acid headgroup shows more systemic promise than its mannosyl analogue as DNA vaccine carrier in dendritic cell based genetic immunizationQ42830712
Glycosidic Tn-based vaccines targeting dermal dendritic cells favor germinal center B-cell development and potent antibody response in the absence of adjuvantQ42933566
Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cellsQ43120646
Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergenQ43468956
Mannose polyethylenimine conjugates for targeted DNA delivery into dendritic cellsQ43552844
DCIR acts as an inhibitory receptor depending on its immunoreceptor tyrosine-based inhibitory motifQ43883767
The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cellsQ43891685
Two distinct types of Langerhans cells populate the skin during steady state and inflammationQ43924469
The macrophage C-type lectin specific for galactose/N-acetylgalactosamine is an endocytic receptor expressed on monocyte-derived immature dendritic cellsQ43937127
Decreased pathology and prolonged survival of human DC-SIGN transgenic mice during mycobacterial infectionQ44331115
Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responsesQ44606736
Interaction of dendritic cells with antigen-containing liposomes: effect of bilayer compositionQ44879296
Targeting dendritic cells with antigen-containing liposomes: a highly effective procedure for induction of antitumor immunity and for tumor immunotherapyQ44942720
Macrophage heterogeneity in lymphoid tissuesQ44969513
Glycan-modified liposomes boost CD4+ and CD8+ T-cell responses by targeting DC-SIGN on dendritic cellsQ45153139
Laminarin-mediated targeting to Dectin-1 enhances antigen-specific immune responsesQ45348881
The adjuvanticity of a mannosylated antigen reveals TLR4 functionality essential for subset specialization and functional maturation of mouse dendritic cellsQ45653426
DCIR is endocytosed into human dendritic cells and inhibits TLR8-mediated cytokine productionQ46084329
Influence of ligand valency on the targeting of immature human dendritic cells by mannosylated liposomesQ46216588
Transcriptional profiling of human skin-resident Langerhans cells and CD1a+ dermal dendritic cells: differential activation states suggest distinct functionsQ46626936
Spatial and mechanistic separation of cross-presentation and endogenous antigen presentationQ46674193
Delivery of antigen using a novel mannosylated dendrimer potentiates immunogenicity in vitro and in vivoQ46804413
Glycan modification of the tumor antigen gp100 targets DC-SIGN to enhance dendritic cell induced antigen presentation to T cellsQ46934267
Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow.Q47687570
Potent antitumor immunity generated by a CD40-targeted adenoviral vaccine.Q50064816
Induction of antigen-specific immunity with a vaccine targeting NY-ESO-1 to the dendritic cell receptor DEC-205.Q50457532
High and interrelated rates of PD-L1+CD14+ antigen-presenting cells and regulatory T cells mark the microenvironment of metastatic lymph nodes from patients with cervical cancer.Q50773034
CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis.Q50787445
Lectin Receptors Expressed on Myeloid Cells.Q51364012
Effective induction of naive and recall T-cell responses by targeting antigen to human dendritic cells via a humanized anti-DC-SIGN antibody.Q51475003
Targeting DC-SIGN via its neck region leads to prolonged antigen residence in early endosomes, delayed lysosomal degradation, and cross-presentation.Q51765801
Tumour-associated glycan modifications of antigen enhance MGL2 dependent uptake and MHC class I restricted CD8 T cell responses.Q51773605
MGL-mediated internalization and antigen presentation by dendritic cells: a role for tyrosine-5.Q51796251
Regulation of effector T cells by antigen-presenting cells via interaction of the C-type lectin MGL with CD45.Q51803715
The vast majority of CLA+ T cells are resident in normal skin.Q51984006
Cutting edge: generation of splenic CD8+ and CD8- dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow cultures.Q52049353
Selective expression of the chemokine receptor XCR1 on cross-presenting dendritic cells determines cooperation with CD8+ T cells.Q52907264
Targeting antigen to mouse dendritic cells via Clec9A induces potent CD4 T cell responses biased toward a follicular helper phenotype.Q53085484
Self-renewal capacity of human epidermal Langerhans cells: observations made on a composite tissue allograft.Q53306436
Origin of dendritic cells in peripheral lymphoid organs of mice.Q53558035
A postmigrational switch among skin-derived dendritic cells to a macrophage-like phenotype is predetermined by the intracutaneous cytokine balance.Q53619786
Ex vivo targeting of the macrophage mannose receptor generates anti-tumor CTL responses.Q54047916
Intradermal delivery of TLR agonists in a human explant skin model: preferential activation of migratory dendritic cells by polyribosinic-polyribocytidylic acid and peptidoglycans.Q54445726
Exposure of CD34+ precursors to cytostatic anthraquinone-derivatives induces rapid dendritic cell differentiation: implications for cancer immunotherapy.Q39482884
Antibody-targeted NY-ESO-1 to mannose receptor or DEC-205 in vitro elicits dual human CD8+ and CD4+ T cell responses with broad antigen specificityQ39621141
Tumor- and Neoantigen-Reactive T-cell Receptors Can Be Identified Based on Their Frequency in Fresh TumorQ39647119
Concomitant activation and antigen uptake via human dectin-1 results in potent antigen-specific CD8+ T cell responsesQ39664739
Characterization of murine MGL1 and MGL2 C-type lectins: distinct glycan specificities and tumor binding propertiesQ39892006
Oligomannose-coated liposomes as a therapeutic antigen-delivery and an adjuvant vehicle for induction of in vivo tumor immunityQ39981419
Inducing antitumor T cell immunity: comparative functional analysis of interstitial versus Langerhans dendritic cells in a human cell line model.Q40000399
Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-alpha productionQ40015356
In vivo targeting of antigens to human dendritic cells through DC-SIGN elicits stimulatory immune responses and inhibits tumor growth in grafted mouse modelsQ40076581
The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+ Macrophages or Monocyte-Derived Dendritic CellsQ40172102
Toll-like receptor activation enhances cell-mediated immunity induced by an antibody vaccine targeting human dendritic cellsQ40179067
Modular expression analysis reveals functional conservation between human Langerhans cells and mouse cross-priming dendritic cells.Q40253946
Enhanced DNA vaccine potency by mannosylated lipoplex after intraperitoneal administrationQ40290035
Expression of human DEC-205 (CD205) multilectin receptor on leukocytes.Q40297027
Antibody-mediated targeting of antigen to C-type lectin-like receptors Clec9A and Clec12A elicits different vaccination outcomes.Q40408582
Carbohydrate profiling reveals a distinctive role for the C-type lectin MGL in the recognition of helminth parasites and tumor antigens by dendritic cellsQ40440515
Langerin-mediated internalization of a modified peptide routes antigens to early endosomes and enhances cross-presentation by human Langerhans cellsQ40443196
Enhanced antitumor immunity by targeting dendritic cells with tumor cell lysate-loaded chitosan nanoparticles vaccine.Q40462465
Enhanced Humoral Responses Induced by Targeting of Antigen to Murine Dendritic CellsQ40565323
Mannose receptor targeting of tumor antigen pmel17 to human dendritic cells directs anti-melanoma T cell responses via multiple HLA moleculesQ40587048
Antigen targeting reveals splenic CD169+ macrophages as promoters of germinal center B-cell responsesQ40593868
Spatiotemporally Distinct Interactions with Dendritic Cell Subsets Facilitates CD4+ and CD8+ T Cell Activation to Localized Viral InfectionQ40617421
A phase 1a, first-in-human, randomized study of a respiratory syncytial virus F protein vaccine with and without a toll-like receptor-4 agonist and stable emulsion adjuvantQ40787014
Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cellsQ40952120
In situ Delivery of Antigen to DC-SIGN(+)CD14(+) Dermal Dendritic Cells Results in Enhanced CD8(+) T-Cell ResponsesQ41054995
Targeting dendritic cells in humanized mice receiving adoptive T cells via monoclonal antibodies fused to Flu epitopesQ41080657
Comparative genomics analysis of mononuclear phagocyte subsets confirms homology between lymphoid tissue-resident and dermal XCR1(+) DCs in mouse and human and distinguishes them from Langerhans cellsQ41112925
Klf4 expression in conventional dendritic cells is required for T helper 2 cell responses.Q41214702
Targeting to porcine sialoadhesin receptor improves antigen presentation to T cells.Q41537516
Antibodies targeting Clec9A promote strong humoral immunity without adjuvant in mice and non-human primatesQ41610389
Plasmacytoid dendritic cells efficiently cross-prime naive T cells in vivo after TLR activation.Q41819217
IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microgliaQ37615661
Induction of innate and adaptive immunity by delivery of poly dA:dT to dendritic cellsQ37626826
Deciphering the transcriptional network of the dendritic cell lineageQ37700905
The dermis as a portal for dendritic cell-targeted immunotherapy of cutaneous melanomaQ37890966
CDX-1307: a novel vaccine under study as treatment for muscle-invasive bladder cancer.Q37892578
An evolutionary perspective on C-type lectins in infection and immunityQ37979878
Multivalency as a chemical organization and action principleQ38041060
The physiological role of DC-SIGN: a tale of mice and men.Q38100871
Skin-resident antigen-presenting cells: instruction manual for vaccine developmentQ38117141
Inflammatory dendritic cells in mice and humansQ38119788
Dendritic Cell Plasticity in Tumor-Conditioned Skin: CD14(+) Cells at the Cross-Roads of Immune Activation and SuppressionQ38170109
Cross-presentation by human dendritic cell subsetsQ38170876
The origins and functions of dendritic cells and macrophages in the skinQ38214043
Human skin dendritic cells in health and diseaseQ38258710
Synthesis of glycocluster-tumor antigenic peptide conjugates for dendritic cell targeting.Q38300387
Cross-presentation through langerin and DC-SIGN targeting requires different formulations of glycan-modified antigensQ38301229
Enhanced immunogenicity of a tricomponent mannan tetanus toxoid conjugate vaccine targeted to dendritic cells via Dectin-1 by incorporating β-glucanQ38316887
Purification and properties of sialoadhesin, a sialic acid-binding receptor of murine tissue macrophages.Q38334463
Design of neo-glycoconjugates that target the mannose receptor and enhance TLR-independent cross-presentation and Th1 polarizationQ38336731
High and low affinity carbohydrate ligands revealed for murine SIGN-R1 by carbohydrate array and cell binding approaches, and differing specificities for SIGN-R3 and langerinQ38341351
Characterization of carbohydrate recognition by langerin, a C-type lectin of Langerhans cellsQ38356938
Cross-Presentation in Mouse and Human Dendritic CellsQ38527616
Matched skin and sentinel lymph node samples of melanoma patients reveal exclusive migration of mature dendritic cellsQ38597659
Langerhans cell origin and regulationQ38629610
Human lymphoid organ dendritic cell identity is predominantly dictated by ontogeny, not tissue microenvironmentQ38636864
Expansion and Activation of CD103(+) Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition.Q38776860
Dendritic Cell-Based Immunotherapy: State of the Art and Beyond.Q38809786
Rational Design of Adjuvant for Skin Delivery: Conjugation of Synthetic β-Glucan Dectin-1 Agonist to Protein AntigenQ38888077
High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanomaQ38926293
Targeted delivery of α-galactosylceramide to CD8α+ dendritic cells optimizes type I NKT cell-based antitumor responsesQ38986327
Antigen delivery to CD11c+CD8- dendritic cells induces protective immune responses against experimental melanoma in mice in vivo.Q38994851
Antigen-Presenting Cells in the SkinQ39146789
DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissuesQ39374974
CLEC12A-Mediated Antigen Uptake and Cross-Presentation by Human Dendritic Cell Subsets Efficiently Boost Tumor-Reactive T Cell Responses.Q39448429
Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cellsQ85634389
Arming the Melanoma Sentinel Lymph Node through Local Administration of CpG-B and GM-CSF: Recruitment and Activation of BDCA3/CD141(+) Dendritic Cells and Enhanced Cross-PresentationQ86623565
Targeting nanoparticles to CD40, DEC-205 or CD11c molecules on dendritic cells for efficient CD8(+) T cell response: a comparative studyQ87455611
Topical rather than intradermal application of the TLR7 ligand imiquimod leads to human dermal dendritic cell maturation and CD8+ T-cell cross-primingQ87870332
Antitumor activity of liposomal ErbB2/HER2 epitope peptide-based vaccine constructs incorporating TLR agonists and mannose receptor targeting.Q54598048
Antigen crosspresentation by human plasmacytoid dendritic cells.Q55044627
CD169-positive macrophages dominate antitumor immunity by crosspresenting dead cell-associated antigens.Q55053710
F-Actin Is an Evolutionarily Conserved Damage-Associated Molecular Pattern Recognized by DNGR-1, a Receptor for Dead CellsQ56880701
Intradermal CpG-B activates both plasmacytoid and myeloid dendritic cells in the sentinel lymph node of melanoma patientsQ56901384
Antigen Presentation the Macrophage WayQ56988446
The C-Type Lectin Clec12A Present on Mouse and Human Dendritic Cells Can Serve as a Target for Antigen Delivery and Enhancement of Antibody ResponsesQ57133306
Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activationQ57195316
Tumor-Associated Tn-MUC1 Glycoform Is Internalized through the Macrophage Galactose-Type C-Type Lectin and Delivered to the HLA Class I and II Compartments in Dendritic CellsQ57195392
Targeting glycan modified OVA to murine DC-SIGN transgenic dendritic cells enhances MHC class I and II presentationQ57261981
Cell-mediated immune responses to MUC1 fusion protein coupled to mannanQ57594351
Natural Human Plasmacytoid Dendritic Cells Induce Antigen-Specific T-Cell Responses in Melanoma PatientsQ57779512
Effective Clinical Responses in Metastatic Melanoma Patients after Vaccination with Primary Myeloid Dendritic CellsQ58619819
Targeting Uptake Receptors on Human Plasmacytoid Dendritic Cells Triggers Antigen Cross-Presentation and Robust Type I IFN SecretionQ58619877
Comparison of antibodies and carbohydrates to target vaccines to human dendritic cells via DC-SIGNQ58619885
The C-type lectin receptor CLEC9A mediates antigen uptake and (cross-)presentation by human blood BDCA3+ myeloid dendritic cellsQ58619899
DEC-205 mediates antigen uptake and presentation by both resting and activated human plasmacytoid dendritic cellsQ58619914
In Vivo Targeting of DC-SIGN-positive Antigen-presenting Cells in a Nonhuman Primate ModelQ58619996
Mannan Mucin-1 Peptide Immunization: Influence of Cyclophosphamide and the Route of InjectionQ74186524
Development of a cancer vaccine: peptides, proteins, and DNAQ74194968
Lewis X oligosaccharides targeting to DC-SIGN enhanced antigen-specific immune responseQ79983205
Preferential induction of CD4+ T cell responses through in vivo targeting of antigen to dendritic cell-associated C-type lectin-1Q80057988
Cutting edge: langerin/CD207 receptor on dendritic cells mediates efficient antigen presentation on MHC I and II products in vivoQ80825231
Local administration of granulocyte/macrophage colony-stimulating factor increases the number and activation state of dendritic cells in the sentinel lymph node of early-stage melanomaQ81019105
Single chain antibody fragments for the selective targeting of antigens to dendritic cellsQ81647965
The C-type lectin macrophage galactose-type lectin impedes migration of immature APCsQ81803363
Inhibition of melanoma growth by targeting of antigen to dendritic cells via an anti-DEC-205 single-chain fragment variable moleculeQ82994736
Tumor-specific CD8+ T cell reactivity in the sentinel lymph node of GM-CSF-treated stage I melanoma patients is associated with high myeloid dendritic cell contentQ83289196
Delivery of antigen to sialoadhesin or CD163 improves the specific immune response in pigsQ84072295
Activation of antigen-specific T cell-responses by mannan-decorated PLGA nanoparticlesQ84074937
Vaccination with filamentous bacteriophages targeting DEC-205 induces DC maturation and potent anti-tumor T-cell responses in the absence of adjuvantsQ84396239
Targeting of DEC-205 on human dendritic cells results in efficient MHC class II-restricted antigen presentationQ84450879
Characterization of four conventional dendritic cell subsets in human skin-draining lymph nodes in relation to T-cell activationQ84547662
Human Langerhans cells use an IL-15R-α/IL-15/pSTAT5-dependent mechanism to break T-cell tolerance against the self-differentiation tumor antigen WT1.Q36014997
Low Mutation Burden in Ovarian Cancer May Limit the Utility of Neoantigen-Targeted Vaccines.Q36021163
Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophagesQ36021832
Robust Anti-viral Immunity Requires Multiple Distinct T Cell-Dendritic Cell InteractionsQ36054488
Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult miceQ34214131
Human dermal CD14⁺ cells are a transient population of monocyte-derived macrophagesQ34244161
Improved cellular and humoral immune responses in vivo following targeting of HIV Gag to dendritic cells within human anti–human DEC205 monoclonal antibodyQ34310888
KLRL1, a novel killer cell lectinlike receptor, inhibits natural killer cell cytotoxicityQ34331615
Antibody-antigen-adjuvant conjugates enable co-delivery of antigen and adjuvant to dendritic cells in cis but only have partial targeting specificityQ34341859
Murine Langerin+ dermal dendritic cells prime CD8+ T cells while Langerhans cells induce cross-toleranceQ34342500
Targeting DNGR-1 (CLEC9A) with antibody/MUC1 peptide conjugates as a vaccine for carcinomas.Q34406488
Neoantigens in cancer immunotherapy.Q34470074
Dendritic cell immunotherapy: clinical outcomesQ34511606
Combination immunotherapy: a road map.Q34552128
Transcriptional profiling of human dendritic cell populations and models--unique profiles of in vitro dendritic cells and implications on functionality and applicabilityQ34558328
Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A.Q34573130
Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation.Q34623431
Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunityQ34625640
T cell memory. A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cellsQ34626234
Survey of immune-related, mannose/fucose-binding C-type lectin receptors reveals widely divergent sugar-binding specificitiesQ34661542
IL-10 conditioning of human skin affects the distribution of migratory dendritic cell subsets and functional T cell differentiation.Q34854946
Targeting the non-structural protein 1 from dengue virus to a dendritic cell population confers protective immunity to lethal virus challengeQ34855420
Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microgliaQ34918881
DNA vaccines targeting the encoded antigens to dendritic cells induce potent antitumor immunity in miceQ34939255
Intestinal lamina propria dendritic cell subsets have different origin and functions.Q35001346
Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skinQ35030843
Virological and preclinical characterization of a dendritic cell targeting, integration-deficient lentiviral vector for cancer immunotherapyQ35069876
IRF8 mutations and human dendritic-cell immunodeficiencyQ35106002
Phase I study utilizing a novel antigen-presenting cell-targeted vaccine with Toll-like receptor stimulation to induce immunity to self-antigens in cancer patientsQ35116211
Epidermal Langerhans cells rapidly capture and present antigens from C-type lectin-targeting antibodies deposited in the dermis.Q35119724
Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas.Q35148879
Proinflammatory microenvironments within the intestine regulate the differentiation of tissue-resident CD8⁺ T cells responding to infectionQ35202406
Enhanced cross-presentation and improved CD8+ T cell responses after mannosylation of synthetic long peptides in miceQ35227905
CD169+ macrophages are sufficient for priming of CTLs with specificities left out by cross-priming dendritic cellsQ35567056
Self- and nonself-recognition by C-type lectins on dendritic cellsQ35698392
Characterization of resident and migratory dendritic cells in human lymph nodesQ35894149
The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected miceQ35913706
Mannose receptor-targeted vaccinesQ35967297
P275copyright licenseCreative Commons Attribution-NonCommercial 4.0 InternationalQ34179348
P921main subjectdendritic cellQ506253
neoplasmQ1216998
cancer vaccineQ2378309
helper-inducer T-lymphocytesQ65983548
C-type lectinsQ66023678
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P577publication date2017-07-20
2017-10-01
P1433published inJournal of Leukocyte BiologyQ1524048
P1476titleTargeting C-type lectin receptors: a high-carbohydrate diet for dendritic cells to improve cancer vaccines

Reverse relations

cites work (P2860)
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Q58761430Comparison of Protein and Peptide Targeting for the Development of a CD169-Based Vaccination Strategy Against Melanoma
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Q92988727Glycan-Modified Apoptotic Melanoma-Derived Extracellular Vesicles as Antigen Source for Anti-Tumor Vaccination
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Q52584422Targeting Mycobacterium tuberculosis Antigens to Dendritic Cells via the DC-Specific-ICAM3-Grabbing-Nonintegrin Receptor Induces Strong T-Helper 1 Immune Responses.
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Q64057499Use of Dendritic Cell Receptors as Targets for Enhancing Anti-Cancer Immune Responses
Q89965725Various Tastes of Sugar: The Potential of Glycosylation in Targeting and Modulating Human Immunity via C-Type Lectin Receptors

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