RNAi-Mediated CCR5 Knockdown Provides HIV-1 Resistance to Memory T Cells in Humanized BLT Mice

scientific article published on 17 February 2015

RNAi-Mediated CCR5 Knockdown Provides HIV-1 Resistance to Memory T Cells in Humanized BLT Mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/MTNA.2015.3
P932PMC publication ID4345313
P698PubMed publication ID25689223
P5875ResearchGate publication ID272512303

P2093author name stringDavid Elashoff
Jerome A Zack
Saki Shimizu
Irvin S Y Chen
Dong Sung An
Gene-Errol Ringpis
Matthew D Marsden
Holly M Wilhalme
Ruth V Cortado
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Functional deletion of the CCR5 receptor by intracellular immunization produces cells that are refractory to CCR5-dependent HIV-1 infection and cell fusionQ24678540
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Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor geneQ29614892
Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infectionQ29614956
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A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse modelQ33697336
Naïve and memory CD4 T cells differ in their susceptibilities to human immunodeficiency virus type 1 infection following CD28 costimulation: implicatip6s for transmission and pathogenesis.Q33784940
Up-regulation of CCR5 and CCR6 on distinct subpopulations of antigen-activated CD4+ T lymphocytesQ34105986
Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivoQ34124290
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Inhibition of HIV-1 infection by lentiviral vectors expressing Pol III-promoted anti-HIV RNAs.Q34220767
High CCR5 density on central memory CD4+ T cells in acute HIV-1 infection is mostly associated with rapid disease progressionQ34490116
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Stem cell-based anti-HIV gene therapyQ34769333
Inhibition of HIV-1 infection by a unique short hairpin RNA to chemokine receptor 5 delivered into macrophages through hematopoietic progenitor cell transductionQ35122039
Generation of HIV latency in humanized BLT miceQ35666126
Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primatesQ35928777
Generation of an HIV-1-resistant immune system with CD34(+) hematopoietic stem cells transduced with a triple-combination anti-HIV lentiviral vector.Q35943417
The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytesQ36028490
Stable gene transfer of CCR5 and CXCR4 siRNAs by sleeping beauty transposon system to confer HIV-1 resistanceQ36870325
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Specific transduction of HIV-susceptible cells for CCR5 knockdown and resistance to HIV infection: a novel method for targeted gene therapy and intracellular immunization.Q37184391
CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activityQ37271186
P304page(s)e227
P577publication date2015-02-17
P1433published inMolecular Therapy. Nucleic acidsQ27724110
P1476titleRNAi-Mediated CCR5 Knockdown Provides HIV-1 Resistance to Memory T Cells in Humanized BLT Mice
P478volume4

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