An unbiased genome-wide analysis of zinc-finger nuclease specificity

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An unbiased genome-wide analysis of zinc-finger nuclease specificity is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1033698278
P356DOI10.1038/NBT.1948
P8608Fatcat IDrelease_fnpauh4q3fahdp5s7g45kio3gq
P698PubMed publication ID21822255
P5875ResearchGate publication ID51552709

P50authorChristof von KalleQ1084355
Luigi NaldiniQ16574299
Angelo Leone LombardoQ43197801
Philip D GregoryQ54131584
Pietro GenoveseQ56826350
Manfred SchmidtQ100717967
P2093author name stringJeffrey C Miller
Michael C Holmes
Jianbin Wang
Cynthia C Bartholomae
Ali Nowrouzi
Anne Arens
Christine Kaeppel
Hanno Glimm
Richard Gabriel
Geoffrey Friedman
P2860cites workHybrid restriction enzymes: zinc finger fusions to Fok I cleavage domainQ24567623
Knockout rats via embryo microinjection of zinc-finger nucleasesQ24633888
Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modificationQ24651280
FokI dimerization is required for DNA cleavageQ24657843
BLAT—The BLAST-Like Alignment ToolQ24682492
Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferencesQ24798872
Basic local alignment search toolQ25938991
Enhancing Gene Targeting with Designed Zinc Finger NucleasesQ28202461
Highly efficient endogenous human gene correction using designed zinc-finger nucleasesQ28243157
Distinct factors control histone variant H3.3 localization at specific genomic regionsQ28275277
Genome editing with engineered zinc finger nucleasesQ28290795
An improved zinc-finger nuclease architecture for highly specific genome editingQ28307951
Capture of DNA sequences at double-strand breaks in mammalian chromosomesQ28346450
Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector deliveryQ29014419
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vectorQ29547503
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleasesQ29615069
HIV-1 integration in the human genome favors active genes and local hotspotsQ29618457
Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleasesQ29622846
Rapid and efficient clathrin-mediated endocytosis revealed in genome-edited mammalian cellsQ30585064
Mutations in the human immunodeficiency virus type 1 integrase D,D(35)E motif do not eliminate provirus formation.Q33783966
Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domainsQ33786657
Stimulation of homologous recombination through targeted cleavage by chimeric nucleasesQ33927812
Promiscuous patching of broken chromosomes in mammalian cells with extrachromosomal DNA.Q33948430
Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genomeQ34018343
The discovery of zinc fingers and their applications in gene regulation and genome manipulation.Q34101354
A rapid and general assay for monitoring endogenous gene modificationQ34129397
Binding of two zinc finger nuclease monomers to two specific sites is required for effective double-strand DNA cleavageQ34222841
Targeted chromosomal cleavage and mutagenesis in Drosophila using zinc-finger nucleasesQ34615432
Role of the non-homologous DNA end joining pathway in the early steps of retroviral infectionQ34770002
Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic riskQ35038004
Targeted gene addition into a specified location in the human genome using designed zinc finger nucleasesQ35645641
Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapyQ35916142
Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases.Q36545930
Expanding or restricting the target site repertoire of zinc-finger nucleases: the inter-domain linker as a major determinant of target site selectivityQ39500874
Frequent endonuclease cleavage at off-target locations in vivo.Q39729952
Generation of a triple-gene knockout mammalian cell line using engineered zinc-finger nucleases.Q39756306
Non-homologous end-joining for repairing I-SceI-induced DNA double strand breaks in human cellsQ40171846
Transient gene expression by nonintegrating lentiviral vectorsQ40300665
Adeno-associated virus vectors integrate at chromosome breakage sitesQ40543184
Novel integrase-defective lentiviral episomal vectors for gene transferQ44423281
Comprehensive genomic access to vector integration in clinical gene therapyQ45855528
Genome-wide high-throughput integrome analyses by nrLAM-PCR and next-generation sequencingQ45862487
High-resolution insertion-site analysis by linear amplification-mediated PCR (LAM-PCR).Q45873348
Targeted genome modifications using integrase-deficient lentiviral vectors.Q50657873
FokI requires two specific DNA sites for cleavageQ74326486
P433issue9
P921main subjectbiasQ742736
P304page(s)816-823
P577publication date2011-08-07
P1433published inNature BiotechnologyQ1893837
P1476titleAn unbiased genome-wide analysis of zinc-finger nuclease specificity
P478volume29

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