T-cell therapies for HIV: Preclinical successes and current clinical strategies.

scientific article published on 2 June 2016

T-cell therapies for HIV: Preclinical successes and current clinical strategies. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/J.JCYT.2016.04.007
P932PMC publication ID4935558
P698PubMed publication ID27265874

P50authorShabnum PatelQ87592399
Catherine M BollardQ91774704
P2093author name stringDouglas F Nixon
R Brad Jones
P2860cites workGenotypic and phenotypic characterization of HIV-1 patients with primary infectionQ22242245
RNA-guided human genome engineering via Cas9Q24598394
Genetic engineering of T cells for adoptive immunotherapyQ24642718
FokI dimerization is required for DNA cleavageQ24657843
Adoptive T cell therapy for cancer in the clinicQ24680405
Impact of HIV-related stigma on treatment adherence: systematic review and meta-synthesisQ26830838
CD4 T-cell immunotherapy for chronic viral infections and cancerQ27022957
Histone deacetylase inhibitors impair the elimination of HIV-infected cells by cytotoxic T-lymphocytesQ27324527
Engineering T Cells to Functionally Cure HIV-1 InfectionQ28086801
Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIVQ28235281
Eradication of HIV by transplantation of CCR5-deficient hematopoietic stem cellsQ28237048
Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selectionQ28245039
Use of a zinc-finger consensus sequence framework and specificity rules to design specific DNA binding proteinsQ28267567
Restoring function in exhausted CD8 T cells during chronic viral infectionQ28289222
CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21Q28307312
Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cellsQ28754733
Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantationQ29615068
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleasesQ29615069
DNA targeting specificity of RNA-guided Cas9 nucleasesQ29615793
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cellsQ29616045
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progressionQ29618956
T cell exhaustionQ29620463
Association between virus-specific cytotoxic T-lymphocyte and helper responses in human immunodeficiency virus type 1 infectionQ33817504
Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleasesQ33886716
HIV preferentially infects HIV-specific CD4+ T cellsQ33958893
Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infectionQ34093225
Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load.Q34468117
Clinical application of genetically modified T cells in cancer therapyQ34511646
Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunctionQ34570127
Enhancing SIV-specific immunity in vivo by PD-1 blockadeQ34601856
Transcriptional profiling of CD4 T cells identifies distinct subgroups of HIV-1 elite controllersQ34625953
Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirusQ34655645
Chemokine receptor 5 knockout strategiesQ34734219
HIV-specific CD8+ T cells from HIV+ individuals receiving HAART can be expanded ex vivo to augment systemic and mucosal immunity in vivoQ35029956
Decade-long safety and function of retroviral-modified chimeric antigen receptor T cellsQ35202343
HIV Excision Utilizing CRISPR/Cas9 Technology: Attacking the Proviral Quasispecies in Reservoirs to Achieve a CureQ35447267
Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutationsQ35521811
Improving T-cell therapy for relapsed EBV-negative Hodgkin lymphoma by targeting upregulated MAGE-A4Q35556061
Broadly-specific cytotoxic T cells targeting multiple HIV antigens are expanded from HIV+ patients: implications for immunotherapyQ35653249
Expanded cytotoxic T-cell lymphocytes target the latent HIV reservoirQ35812943
Zinc-finger nuclease editing of human cxcr4 promotes HIV-1 CD4(+) T cell resistance and enrichmentQ35876209
Length-encoded multiplex binding site determination: application to zinc finger proteinsQ35896081
Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primatesQ35928777
Interplay between T cell receptor binding kinetics and the level of cognate peptide presented by major histocompatibility complexes governs CD8+ T cell responsivenessQ36080586
Elite controllers with low to absent effector CD8+ T cell responses maintain highly functional, broadly directed central memory responsesQ36086732
Genome editing of CXCR4 by CRISPR/cas9 confers cells resistant to HIV-1 infection.Q36181852
Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primatesQ36183567
The Breadth of Expandable Memory CD8+ T Cells Inversely Correlates with Residual Viral Loads in HIV Elite ControllersQ36208223
Change in coreceptor use correlates with disease progression in HIV-1--infected individualsQ36376800
Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivationQ36409885
How do CARs work?: Early insights from recent clinical studies targeting CD19.Q36476104
Lentiviral vectors encoding human immunodeficiency virus type 1 (HIV-1)-specific T-cell receptor genes efficiently convert peripheral blood CD8 T lymphocytes into cytotoxic T lymphocytes with potent in vitro and in vivo HIV-1-specific inhibitory actQ36484055
Efficiency of CD19 chimeric antigen receptor-modified T cells for treatment of B cell malignancies in phase I clinical trials: a meta-analysisQ36545348
Functionally Active HIV-Specific T Cells that Target Gag and Nef Can Be Expanded from Virus-Naïve Donors and Target a Range of Viral Epitopes: Implications for a Cure Strategy after Allogeneic Hematopoietic Stem Cell TransplantationQ36578672
Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infectionQ36979967
Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma.Q37095348
Exploiting the curative potential of adoptive T-cell therapy for cancerQ37576033
The time is now: moving toward virus-specific T cells after allogeneic hematopoietic stem cell transplantation as the standard of careQ37592177
Differential impact of PD-1 and/or interleukin-10 blockade on HIV-1-specific CD4 T cell and antigen-presenting cell functionsQ37644041
CD19-CAR trialsQ37692134
Antibody-modified T cells: CARs take the front seat for hematologic malignanciesQ37723469
HIV-specific CD4 T cells and immune control of viral replicationQ37866624
From crucial to negligible: functional CD8⁺ T-cell responses and their dependence on CD4⁺ T-cell helpQ38005963
HIV infection and depressionQ38189503
HIV-1 adaptation to HLA: a window into virus-host immune interactionsQ38329384
High-Throughput Silencing Using the CRISPR-Cas9 System: A Review of the Benefits and ChallengesQ38498286
Inhibition of HIV-1 infection of primary CD4+ T-cells by gene editing of CCR5 using adenovirus-delivered CRISPR/Cas9.Q38889625
Identification of a Titin-derived HLA-A1-presented peptide as a cross-reactive target for engineered MAGE A3-directed T cellsQ39113639
CCR5 Disruption in Induced Pluripotent Stem Cells Using CRISPR/Cas9 Provides Selective Resistance of Immune Cells to CCR5-tropic HIV-1 VirusQ39119223
An unbiased genome-wide analysis of zinc-finger nuclease specificityQ39493921
T-cell engineering by a chimeric T-cell receptor with antibody-type specificity for the HIV-1 gp120.Q40501551
Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptorQ41410840
The functional aspects of bacterial CRISPR-cas systems and interactions between phages and its bacterial hosts--a reviewQ41678465
CCR5 Gene Editing of Resting CD4(+) T Cells by Transient ZFN Expression From HIV Envelope Pseudotyped Nonintegrating Lentivirus Confers HIV-1 Resistance in Humanized MiceQ41721624
Prolonged survival and tissue trafficking following adoptive transfer of CD4zeta gene-modified autologous CD4(+) and CD8(+) T cells in human immunodeficiency virus-infected subjectsQ41750120
CD4 T-cell regeneration in HIV-1 elite controllersQ41996620
Safety and stability of retrovirally transduced chimeric antigen receptor T cellsQ44057238
A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapyQ44165805
Safety of autologous, ex vivo-expanded human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte infusion in HIV-infected patients.Q45760355
Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individualsQ45862722
In vivo migration and function of transferred HIV-1-specific cytotoxic T cellsQ47995100
Rapid death of adoptively transferred T cells in acquired immunodeficiency syndrome.Q49086716
A multi-step pace towards a cure for HIV: kick, kill, and contain.Q51866015
HIV: Shock and kill.Q55056512
Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progressionQ71803154
Allogeneic transplantation of CCR5-deficient progenitor cells in a patient with HIV infection: an update after 3 years and the search for patient no. 2Q82971212
[HIV-1 eradication with the "shock and kill" strategy]Q84122710
Multiple Roles of CD4 and CD8 in T Cell ActivationQ84774251
P433issue8
P304page(s)931-942
P577publication date2016-06-02
P1433published inCytotherapyQ5201399
P1476titleT-cell therapies for HIV: Preclinical successes and current clinical strategies
P478volume18

Reverse relations

cites work (P2860)
Q96306123A Trispecific Anti-HIV Chimeric Antigen Receptor Containing the CCR5 N-Terminal Region
Q34047460CRISPR/Cas9 in allergic and immunologic diseases
Q47236016Cell and Gene Therapy for HIV Cure
Q59359586Chimeric antigen receptor T-cell approaches to HIV cure
Q95272150Nanoparticle-Based Immunoengineered Approaches for Combating HIV
Q92436551Review: HIV-1 phylogeny during suppressive antiretroviral therapy
Q52608538Simian Immunodeficiency Virus (SIV)-Specific Chimeric Antigen Receptor-T Cells Engineered to Target B Cell Follicles and Suppress SIV Replication.
Q55078034The Use of the Humanized Mouse Model in Gene Therapy and Immunotherapy for HIV and Cancer.
Q60046873Therapeutic Targeting of HIV Reservoirs: How to Give T Cells a New Direction