Genome editing of CXCR4 by CRISPR/cas9 confers cells resistant to HIV-1 infection.

scientific article

Genome editing of CXCR4 by CRISPR/cas9 confers cells resistant to HIV-1 infection. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SREP15577
P932PMC publication ID4612538
P698PubMed publication ID26481100
P5875ResearchGate publication ID283594093

P50authorDeyin GuoQ39988945
P2093author name stringJian Huang
Yu Chen
Wei Hou
Wenzhe Ho
Xiao Yu
Shuliang Chen
Meng Jiang
Shilei Wang
Panpan Hou
Ke Zhuang
P2860cites workNon-homologous end joining as a mechanism of DNA repairQ74185601
Zinc-finger nuclease editing of human cxcr4 promotes HIV-1 CD4(+) T cell resistance and enrichmentQ35876209
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Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cellsQ37148527
CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activityQ37271186
Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection.Q37429714
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The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entryQ24315492
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Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIVQ28235281
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HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapyQ28339571
CCR5 gene disruption via lentiviral vectors expressing Cas9 and single guided RNA renders cells resistant to HIV-1 infectionQ28542878
CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1Q28646859
Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infectionQ29614956
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Genetic screens in human cells using the CRISPR-Cas9 systemQ29617411
Decay characteristics of HIV-1-infected compartments during combination therapyQ29619375
Neutralization profiles of primary human immunodeficiency virus type 1 isolates in the context of coreceptor usageQ33783714
Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infectionQ33854184
Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleasesQ33886716
CCR5 deficiency is a risk factor for early clinical manifestations of West Nile virus infection but not for viral transmissionQ34108023
RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphomaQ34121209
Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivoQ34124290
A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study TeamQ34438252
Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9Q34727851
DNA double-strand break repair by homologous recombinationQ34835417
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectCRISPRQ412563
Cas9Q16965677
CRISPR-Cas methodQ17310682
P304page(s)15577
P577publication date2015-10-20
P1433published inScientific ReportsQ2261792
P1476titleGenome editing of CXCR4 by CRISPR/cas9 confers cells resistant to HIV-1 infection
P478volume5

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