Chemical and pharmacological studies on enantiomerically pure p-methoxytacripyrines, promising multi-target-directed ligands for the treatment of Alzheimer's disease

scientific article published on 24 August 2011

Chemical and pharmacological studies on enantiomerically pure p-methoxytacripyrines, promising multi-target-directed ligands for the treatment of Alzheimer's disease is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/CMDC.201100239
P698PubMed publication ID21990269
P5875ResearchGate publication ID51709840

P50authorIsabel IriepaQ56925426
Manuela BartoliniQ38802804
Manuela LópezQ39676372
Javier EgeaQ41539393
Ignacio MoraledaQ48131084
Vincenza AndrisanoQ56441574
P2093author name stringAbdelouahid Samadi
José Marco-Contelles
Marco Pistolozzi
Enrique Gálvez
P2860cites workSpecific Targeting of Acetylcholinesterase and Butyrylcholinesterase Recognition Sites. Rational Design of Novel, Selective, and Highly Potent Cholinesterase InhibitorsQ58855822
Heterodimeric Tacrine-Based Acetylcholinesterase Inhibitors: Investigating Ligand−Peripheral Site InteractionsQ59215340
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A new and rapid colorimetric determination of acetylcholinesterase activityQ26778487
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Prazosin-Related Compounds. Effect of Transforming the Piperazinylquinazoline Moiety into an Aminomethyltetrahydroacridine System on the Affinity for α1-AdrenoreceptorsQ29036292
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CSF amyloid-beta-peptides in Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease dementiaQ33239180
N-Methylated peptide inhibitors of beta-amyloid aggregation and toxicity. Optimization of the inhibitor structureQ33253112
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Both the D-(+) and L-(-) enantiomers of nicotine inhibit Abeta aggregation and cytotoxicityQ40597988
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A conformational restriction approach to the development of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for Alzheimer's diseaseQ44586144
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First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor.Q46943887
A gorge-spanning, high-affinity cholinesterase inhibitor to explore beta-amyloid plaques.Q48456115
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Brain acetylcholinesterase promotes amyloid-beta-peptide aggregation but does not hydrolyze amyloid precursor protein peptidesQ48527315
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Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease.Q53290732
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Synthesis and biological evaluation of NO-donor-tacrine hybrids as hepatoprotective anti-Alzheimer drug candidates.Q53391276
P433issue11
P921main subjectAlzheimer's diseaseQ11081
enantiomerQ494483
P304page(s)1990-1997
P577publication date2011-08-24
P1433published inChemMedChemQ2962252
P1476titleChemical and pharmacological studies on enantiomerically pure p-methoxytacripyrines, promising multi-target-directed ligands for the treatment of Alzheimer's disease
P478volume6

Reverse relations

cites work (P2860)
Q569603305-Methyl--(8-(5,6,7,8-tetrahydroacridin-9-ylamino)octyl)-5-indolo[2,3-]quinolin-11-amine: a highly potent human cholinesterase inhibitor
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Q59807620Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer's disease therapy
Q39199947Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase/butyrylcholinesterase inhibitors: effect against amyloid-β-induced neurotoxicity.

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