CDK5 downregulation enhances synaptic plasticity

scientific article published on 9 August 2016

CDK5 downregulation enhances synaptic plasticity is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00018-016-2333-8
P698PubMed publication ID27506619

P50authorGloria Patricia Cardona-GomezQ38322880
Alfredo KirkwoodQ86847004
P2093author name stringNibaldo C Inestrosa
Steffen Härtel
Christian González-Billault
Rafael Andrés Posada-Duque
Felipe Bodaleo
Omar Ramirez
P2860cites workA synaptic model of memory: long-term potentiation in the hippocampusQ22337276
Silencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's miceQ24628256
Local, persistent activation of Rho GTPases during plasticity of single dendritic spinesQ24629206
A hippocampal Cdk5 pathway regulates extinction of contextual fearQ24649571
p120 catenin regulates dendritic spine and synapse development through Rho-family GTPases and cadherinsQ24654118
Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegenerationQ28140796
The molecular basis of CaMKII function in synaptic and behavioural memoryQ28216850
p120-catenin is necessary for neuroprotection induced by CDK5 silencing in models of Alzheimer's diseaseQ28386238
CDK5 knockdown prevents hippocampal degeneration and cognitive dysfunction produced by cerebral ischemiaQ28395690
Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradationQ28506134
Regulation of NMDA receptors by cyclin-dependent kinase-5Q28567371
Cdk5 and Trio modulate endocrine cell exocytosisQ28582462
Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowthQ28594587
Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatumQ28594634
The role of the Rho GTPases in neuronal developmentQ29616295
Molecular mechanisms of dendritic spine morphogenesisQ29903592
Cdk5 is a New Rapid Synaptic Homeostasis Regulator Capable of Initiating the Early Alzheimer-Like PathologyQ30279162
Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neuronsQ33277107
Memory enhancement by targeting Cdk5 regulation of NR2B.Q33566334
Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington's disease mice.Q33713689
Essential roles of Drosophila RhoA in the regulation of neuroblast proliferation and dendritic but not axonal morphogenesisQ33893511
A decade of CDK5.Q34093501
Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's miceQ34159111
Cyclin-dependent protein kinase 5 (Cdk5) and the regulation of neurofilament metabolismQ34180836
Activity-dependent CREB phosphorylation: convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathwayQ34496578
Dendritic spine dynamics.Q34990526
Control of synapse development and plasticity by Rho GTPase regulatory proteins.Q35084942
Constitutive cAMP response element binding protein (CREB) activation by Alzheimer's disease presenilin-driven inositol trisphosphate receptor (InsP3R) Ca2+ signaling.Q35164866
Increasing CREB function in the CA1 region of dorsal hippocampus rescues the spatial memory deficits in a mouse model of Alzheimer's diseaseQ35222767
Cyclin-dependent kinase 5 regulates PSD-95 ubiquitination in neuronsQ35306317
Cdk5 Modulation of mitogen-activated protein kinase signaling regulates neuronal survivalQ35613392
Cyclin-Dependent kinase 5 targeting prevents β-Amyloid aggregation involving glycogen synthase kinase 3β and phosphatases.Q35772503
p35 and Rac1 underlie the neuroprotection and cognitive improvement induced by CDK5 silencingQ35815964
Defective Age-Dependent Metaplasticity in a Mouse Model of Alzheimer's Disease.Q35941413
Synaptic roles of Cdk5: implications in higher cognitive functions and neurodegenerative diseasesQ36442919
Electrical stimulation protocols for hippocampal synaptic plasticity and neuronal hyper-excitability: are they effective or relevant?Q36720349
The roles of cyclin-dependent kinase 5 in dendrite and synapse developmentQ36831780
Potential adaptive function for altered long-term potentiation mechanisms in aging hippocampusQ37040738
Balancing structure and function at hippocampal dendritic spinesQ37088448
Different Rho GTPase-dependent signaling pathways initiate sequential steps in the consolidation of long-term potentiationQ37267709
Recent advances in understanding the roles of Cdk5 in synaptic plasticityQ37482522
Cdk5-mediated phosphorylation of delta-catenin regulates its localization and GluR2-mediated synaptic activityQ37616216
Differential roles for CaM kinases in mediating excitation-morphogenesis coupling during formation and maturation of neuronal circuits.Q37800116
Analysis of CaM-kinase signaling in cellsQ37870268
Truncated TrkB: beyond a dominant negative receptorQ37985103
A Functional Role for CREB as a Positive Regulator of Memory Formation and LTP.Q38074149
Atorvastatin requires geranylgeranyl transferase-I and Rac1 activation to exert neuronal protection and induce plasticityQ38317653
The Cdk5 inhibitor Roscovitine increases LTP induction in corticostriatal synapses.Q38362167
CDK5 knockdown in astrocytes provide neuroprotection as a trophic source via Rac1.Q38854729
Microtubule-associated protein 1B (MAP1B) is required for dendritic spine development and synaptic maturationQ39242448
Insect cells as a factory to produce adeno-associated virus type 2 vectorsQ40690831
Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating.Q41256595
The neuronal architecture of Xenopus retinal ganglion cells is sculpted by rho-family GTPases in vivoQ41691431
Ultrastructure of dendritic spines: correlation between synaptic and spine morphologiesQ42401437
Switching on and off fear by distinct neuronal circuits.Q42438392
Defining mechanisms of actin polymerization and depolymerization during dendritic spine morphogenesisQ43107811
Roscovitine increases intracellular calcium release and capacitative calcium entry in PC12 cellsQ43234303
The role of calcium-calmodulin kinase II in three forms of synaptic plasticityQ43531753
Regulation of rho GTPases by crosstalk and neuronal activity in vivo.Q43906183
Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability.Q44728737
Cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the postsynaptic density protein PSD-95 in neurons.Q44746561
Proteomic analysis of in vivo phosphorylated synaptic proteins.Q45168689
Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalitiesQ45310539
Targeting CDK5 post-stroke provides long-term neuroprotection and rescues synaptic plasticity.Q45857092
Neurotoxic calcium transfer from endoplasmic reticulum to mitochondria is regulated by cyclin-dependent kinase 5-dependent phosphorylation of tau.Q46448197
The p75 neurotrophin receptor negatively modulates dendrite complexity and spine density in hippocampal neurons.Q46776170
Presynaptic calcium is increased during normal synaptic transmission and paired-pulse facilitation, but not in long-term potentiation in area CA1 of hippocampusQ48186242
Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survivalQ48271519
TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory.Q48336985
Enhanced activation of Ca2+/calmodulin-dependent protein kinase II upon downregulation of cyclin-dependent kinase 5-p35.Q48486674
Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice.Q48546084
Excitotoxicity downregulates TrkB.FL signaling and upregulates the neuroprotective truncated TrkB receptors in cultured hippocampal and striatal neurons.Q48593409
Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunctionQ50335730
Cdk5 Regulates Activity-Dependent Gene Expression and Dendrite Development.Q50549989
Dimensions and density of dendritic spines from rat dentate granule cells based on reconstructions from serial electron micrographs.Q52196720
Rho GTPases regulate distinct aspects of dendritic arbor growth in Xenopus central neurons in vivoQ73505059
P433issue1
P921main subjectsynaptic plasticityQ1551556
P304page(s)153-172
P577publication date2016-08-09
P1433published inCellular and Molecular Life SciencesQ5058352
P1476titleCDK5 downregulation enhances synaptic plasticity
P478volume74

Reverse relations

cites work (P2860)
Q47890221Cdk5 Contributes to Huntington's Disease Learning and Memory Deficits via Modulation of Brain Region-Specific Substrates.
Q55177664Cdk5 Inhibitory Peptide Prevents Loss of Dopaminergic Neurons and Alleviates Behavioral Changes in an MPTP Induced Parkinson's Disease Mouse Model.
Q28817091Dementia, Preclinical Studies in Neurodegeneration and its Potential for Translational Medicine in South America
Q41348645Differentially expressed lncRNAs and miRNAs with associated ceRNA networks in aged mice with postoperative cognitive dysfunction.
Q47230764Furin promotes dendritic morphogenesis and learning and memory in transgenic mice.

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