Nilotinib alone or in combination with selumetinib is a drug candidate for neurofibromatosis type 2.

scientific article published on July 2011

Nilotinib alone or in combination with selumetinib is a drug candidate for neurofibromatosis type 2. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NEUONC/NOR056
P932PMC publication ID3129276
P698PubMed publication ID21727212
P5875ResearchGate publication ID51465408

P50authorClemens O. HanemannQ46766795
P2093author name stringSylwia Ammoun
Paul Manley
Marei Caroline Schmid
Joceline Triner
P2860cites workIsolation and characterization of Schwann cells from neurofibromatosis type 2 patientsQ47692368
Differential gene expression between human schwannoma and control Schwann cells.Q54573044
Upregulation of the Rac1/JNK signaling pathway in primary human schwannoma cellsQ73424194
Transduction of wild-type merlin into human schwannoma cells decreases schwannoma cell growth and induces apoptosisQ77437697
Imatinib mesylateQ82507538
Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitorsQ27658951
Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALLQ28246204
News on the genetics, epidemiology, medical care and translational research of SchwannomasQ28283074
ErbB/HER receptor activation and preclinical efficacy of lapatinib in vestibular schwannomaQ30474678
Nilotinib: a second-generation tyrosine kinase inhibitor for the treatment of chronic myelogenous leukemiaQ33382564
Point mutation in the NF2 gene of HEI-193 human schwannoma cells results in the expression of a merlin isoform with attenuated growth suppressive activityQ36445494
Magic but treatable? Tumours due to loss of merlin.Q36972789
Nilotinib concentration in cell lines and primary CD34(+) chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters.Q39807616
Imatinib induces apoptosis by inhibiting PDGF- but not insulin-induced PI 3-kinase/Akt survival signaling in RGC-5 retinal ganglion cells.Q39810675
Human schwannomas express activated platelet-derived growth factor receptors and c-kit and are growth inhibited by Gleevec (Imatinib Mesylate).Q39840621
Dissecting and targeting the growth factor-dependent and growth factor-independent extracellular signal-regulated kinase pathway in human schwannomaQ40075297
EGFR phosphorylation-dependent formation of cell-cell contacts by Ras/Erks cascade inhibitionQ40157531
Imatinib mesylate (Gleevec) inhibits ovarian cancer cell growth through a mechanism dependent on platelet-derived growth factor receptor alpha and Akt inactivationQ40593443
Overexpression of the NF2 gene inhibits schwannoma cell proliferation through promoting PDGFR degradationQ40617267
Growth factors in mechanisms of malignancy: roles for TGF-beta and FGF.Q41155490
Reduced apoptosis rates in human schwannomas.Q42475808
Imatinib targets PDGF signaling in melanoma and host smooth muscle neighboring cells.Q43046973
Clinical pharmacokinetics of the BCR-ABL tyrosine kinase inhibitor nilotinibQ43239053
Targeting ERK1/2 activation and proliferation in human primary schwannoma cells with MEK1/2 inhibitor AZD6244.Q43266903
Safety and pharmacokinetics of the dual action Raf kinase and vascular endothelial growth factor receptor inhibitor, BAY 43-9006, in patients with advanced, refractory solid tumorsQ46630294
Postnatal Schwann cell proliferation but not myelination is strictly and uniquely dependent on cyclin-dependent kinase 4 (cdk4).Q46810958
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)759-766
P577publication date2011-07-01
P1433published inNeuro-OncologyQ15724471
P1476titleNilotinib alone or in combination with selumetinib is a drug candidate for neurofibromatosis type 2
P478volume13

Reverse relations

cites work (P2860)
Q92505476An update on the CNS manifestations of neurofibromatosis type 2
Q46412577Axl/Gas6/NFκB signalling in schwannoma pathological proliferation, adhesion and survival.
Q50352494Bevacizumab decreases vestibular schwannomas growth rate in children and teenagers with neurofibromatosis type 2.
Q30364937Childhood neurofibromatosis type 2 (NF2) and related disorders: from bench to bedside and biologically targeted therapies.
Q57266579Consensus recommendations for current treatments and accelerating clinical trials for patients with neurofibromatosis type 2
Q57172733Contemporary Molecular Biology of Sporadic Vestibular Schwannomas: A Systematic Review and Clinical Implications
Q30389069Development of drug treatments for neurofibromatosis type 2-associated vestibular schwannoma
Q37885731Emerging therapeutic targets in schwannomas and other merlin-deficient tumors
Q30407175Imatinib in neurofibromatosis type 2.
Q28728224Investigation of the in vitro therapeutic efficacy of nilotinib in immortalized human NF2-null vestibular schwannoma cells
Q38010858Merlin, a multi-suppressor from cell membrane to the nucleus
Q35218073Neurofibromatosis-related tumors: emerging biology and therapies
Q42223215Ponatinib promotes a G1 cell-cycle arrest of merlin/NF2-deficient human schwann cells
Q38770185Radiation-Induced Schwannomas and Neurofibromas: A Systematic Review.
Q36189820Role of Merlin/NF2 inactivation in tumor biology
Q38180808Schwannomas and their pathogenesis
Q34393461Targeting the PDGF signaling pathway in tumor treatment
Q38666243The efficacy of lapatinib and nilotinib in combination with radiation therapy in a model of NF2 associated peripheral schwannoma.
Q41135859The p53/mouse double minute 2 homolog complex deregulation in merlin-deficient tumours
Q42509945The role of insulin-like growth factors signaling in merlin-deficient human schwannomas.
Q30357776Therapeutic advances for the tumors associated with neurofibromatosis type 1, type 2, and schwannomatosis

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