Cooperation of E2F-p130 and Sp1-pRb complexes in repression of the Chinese hamster dhfr gene

scientific article published on February 2001

Cooperation of E2F-p130 and Sp1-pRb complexes in repression of the Chinese hamster dhfr gene is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.21.4.1121-1131.2001
P932PMC publication ID99566
P698PubMed publication ID11158299

P50authorNicholas H. HeintzQ109339637
P2093author name stringS Illenye
Y C Chang
P2860cites workMutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteinsQ22253968
Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2FQ24317554
Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activationQ24318303
E2F and histone deacetylase mediate transforming growth factor beta repression of cdc25A during keratinocyte cell cycle arrestQ24554533
Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repressionQ24607675
The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylaseQ24642494
Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interactionQ24650233
Association of p107 with Sp1: genetically separable regions of p107 are involved in regulation of E2F- and Sp1-dependent transcriptionQ24651154
A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressorQ24656541
Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1Q28145116
Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoterQ28146156
Retinoblastoma protein recruits histone deacetylase to repress transcriptionQ28262144
Retinoblastoma protein represses transcription by recruiting a histone deacetylaseQ28262155
Rb Interacts with Histone Deacetylase to Repress TranscriptionQ28263985
A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3pQ28276243
The regulation of E2F by pRB-family proteinsQ28278789
Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family membersQ28291576
The plant amino acid mimosine may inhibit initiation at origins of replication in Chinese hamster cellsQ30311493
Regulation of E2F: a family of transcription factors involved in proliferation controlQ33751868
Regulation of Cellular Genes in a Chromosomal Context by the Retinoblastoma Tumor Suppressor ProteinQ33775157
Histone deacetylase inhibitor activates the p21/WAF1/Cip1 gene promoter through the Sp1 sitesQ33833418
Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virusQ33927279
Histone deacetylase 1 can repress transcription by binding to Sp1.Q33958899
Target gene specificity of E2F and pocket protein family members in living cellsQ33964977
Functional interactions between the retinoblastoma (Rb) protein and Sp-family members: superactivation by Rb requires amino acids necessary for growth suppressionQ34396889
Transcriptional regulation of the dihydrofolate reductase geneQ34732742
Sp-1 binds promoter elements regulated by the RB protein and Sp-1-mediated transcription is stimulated by RB coexpressionQ36234059
Protein-DNA interactions at the major and minor promoters of the divergently transcribed dhfr and rep3 genes during the Chinese hamster ovary cell cycleQ36557150
Position-dependent transcriptional regulation of the murine dihydrofolate reductase promoter by the E2F transactivation domainQ36567545
A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoterQ36676009
Transcription factor E2F is required for efficient expression of the hamster dihydrofolate reductase gene in vitro and in vivoQ36795598
The retinoblastoma gene product regulates Sp1-mediated transcriptionQ36816438
The retinoblastoma gene product RB stimulates Sp1-mediated transcription by liberating Sp1 from a negative regulatorQ38306731
Cell-growth regulation of the hamster dihydrofolate reductase gene promoter by transcription factor Sp1.Q38341788
Regulation of dihydrofolate reductase gene expression and E2F components in human diploid fibroblasts during growth and senescenceQ38353456
Accumulation of E2F-4.DP-1 DNA binding complexes correlates with induction of dhfr gene expression during the G1 to S phase transitionQ39457727
Transcriptional regulation of the dihydrofolate reductase/rep-3 locusQ40647915
Regulation of cell proliferation by the E2F transcription factorsQ40864375
Association with E2F-1 governs intracellular trafficking and polyubiquitination of DP-1.Q40973401
Butyrate Activates the WAF1/Cip1 Gene Promoter through Sp1 Sites in a p53-negative Human Colon Cancer Cell LineQ41092576
Sodium butyrate inhibits the phosphorylation of the retinoblastoma gene product in mouse fibroblasts by a transcription-dependent mechanismQ41225744
Mechanism of active transcriptional repression by the retinoblastoma proteinQ42479902
Activation of the murine dihydrofolate reductase promoter by E2F1. A requirement for CBP recruitmentQ42815429
Growth/cell cycle regulation of Sp1 phosphorylationQ42822980
Distinct roles for Sp1 and E2F sites in the growth/cell cycle regulation of the DHFR promoterQ42834714
pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genesQ54048106
Effect of Differential Polyadenylation and Cell Growth Phase on Dihydrofolate Reductase mRNA StabilityQ61986104
Retinoblastoma protein associates with SP1 and activates the hamster dihydrofolate reductase promoterQ61986108
p21WAF1/CIP1/SDI1 is elevated through a p53-independent pathway by mimosineQ71538039
Mimosine arrests DNA synthesis at replication forks by inhibiting deoxyribonucleotide metabolismQ72167893
Histone deacetylase inhibition selectively alters the activity and expression of cell cycle proteins leading to specific chromatin acetylation and antiproliferative effectsQ73212118
Transcriptional squelching by ectopic expression of E2F-1 and p53 is alleviated by proteasome inhibitors MG-132 and lactacystinQ73615062
Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNFQ73707174
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectcooperationQ380962
P304page(s)1121-1131
P577publication date2001-02-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleCooperation of E2F-p130 and Sp1-pRb complexes in repression of the Chinese hamster dhfr gene
P478volume21

Reverse relations

cites work (P2860)
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