| scholarly article | Q13442814 |
| P356 | DOI | 10.1093/HMG/DDR271 |
| P698 | PubMed publication ID | 21659333 |
| P50 | author | Mar Orzaez | Q57608754 |
| P2093 | author name string | Rodrigo J Carbajo | |
| Enrique Pérez-Payá | |||
| Mónica Sancho | |||
| Antonio Pineda-Lucena | |||
| Andrés E Herrera | |||
| Anna Gortat | |||
| P2860 | cites work | An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9 | Q22009407 |
| Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1 | Q24290112 | ||
| Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c | Q24309066 | ||
| No death without life: vital functions of apoptotic effectors | Q24319057 | ||
| Nonapoptotic role for Apaf-1 in the DNA damage checkpoint | Q40043968 | ||
| Suppression of polyglutamine-induced toxicity in cell and animal models of Huntington's disease by ubiquilin | Q40320091 | ||
| Novel small molecule inhibitors of caspase-3 block cellular and biochemical features of apoptosis | Q40682421 | ||
| Apocytochrome c blocks caspase-9 activation and Bax-induced apoptosis | Q40694903 | ||
| Cell-free systems to study apoptosis | Q40800603 | ||
| Caspases: preparation and characterization | Q41644637 | ||
| Inhibition of human caspases by peptide-based and macromolecular inhibitors | Q42538024 | ||
| Minocycline blocks nitric oxide-induced neurotoxicity by inhibition p38 MAP kinase in rat cerebellar granule neurons | Q43801054 | ||
| Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice | Q43977943 | ||
| Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders. | Q44286601 | ||
| Minocycline inhibits caspase activation and reactivation, increases the ratio of XIAP to smac/DIABLO, and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO. | Q44785095 | ||
| Lack of evidence of direct mitochondrial involvement in the neuroprotective effect of minocycline | Q45157781 | ||
| Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo | Q45294913 | ||
| Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis. | Q45295534 | ||
| Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates | Q45305166 | ||
| Minocycline up-regulates BCL-2 levels in mitochondria and attenuates male germ cell apoptosis | Q46733808 | ||
| Re-evaluation of mitochondrial permeability transition as a primary neuroprotective target of minocycline | Q48386601 | ||
| Bcl-xL does not inhibit the function of Apaf-1. | Q48892500 | ||
| Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease | Q48948068 | ||
| Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways. | Q52652438 | ||
| Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. | Q55035703 | ||
| Epidermal immunization by a needle-free powder delivery technology: Immunogenicity of influenza vaccine and protection in mice | Q56772848 | ||
| Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha | Q24322072 | ||
| Structure of the apoptotic protease-activating factor 1 bound to ADP | Q28245105 | ||
| Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex | Q28263687 | ||
| Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization | Q28275527 | ||
| WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation | Q28290389 | ||
| Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria | Q28574259 | ||
| A unified model for apical caspase activation | Q28609101 | ||
| Identification of compounds with binding affinity to proteins via magnetization transfer from bulk water. | Q30619297 | ||
| NMR spectroscopy techniques for screening and identifying ligand binding to protein receptors | Q30887851 | ||
| Small molecule inhibitors of Apaf-1-related caspase- 3/-9 activation that control mitochondrial-dependent apoptosis | Q33229065 | ||
| Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia | Q33612679 | ||
| Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models | Q33752885 | ||
| An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson's disease | Q33943954 | ||
| Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis. | Q33948101 | ||
| Huntington's disease: the challenge for cell biologists | Q34106564 | ||
| Minocycline: A review of its antibacterial and pharmacokinetic properties and therapeutic use | Q34455914 | ||
| Effects of minocycline on Fas-mediated fulminant hepatitis in mice | Q35048549 | ||
| Cytochrome c binding to Apaf-1: the effects of dATP and ionic strength | Q35350697 | ||
| Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease | Q35918549 | ||
| Tetracyclines: nonantibiotic properties and their clinical implications | Q36380200 | ||
| Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1 | Q36429868 | ||
| Oncogene-dependent apoptosis is mediated by caspase-9. | Q36795978 | ||
| Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury | Q36853743 | ||
| The endoplasmic reticulum and the unfolded protein response | Q37006310 | ||
| Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease | Q37083085 | ||
| Huntington's disease: from pathology and genetics to potential therapies | Q37157909 | ||
| The endoplasmic reticulum in apoptosis and autophagy: role of the BCL-2 protein family. | Q37310187 | ||
| Minocycline and neurodegenerative diseases | Q37314674 | ||
| Mitochondria, Bcl-2 family proteins and apoptosomes: of worms, flies and men. | Q37410556 | ||
| Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis | Q37633650 | ||
| Integrating stress signals at the endoplasmic reticulum: The BCL-2 protein family rheostat. | Q37814626 | ||
| Aven blocks DNA damage-induced apoptosis by stabilising Bcl-xL. | Q39682156 | ||
| A chemical inhibitor of Apaf-1 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint | Q39893781 | ||
| P433 | issue | 18 | |
| P921 | main subject | minocycline | Q415336 |
| cell death | Q2383867 | ||
| P304 | page(s) | 3545-3553 | |
| P577 | publication date | 2011-06-09 | |
| P1433 | published in | Human Molecular Genetics | Q2720965 |
| P1476 | title | Minocycline inhibits cell death and decreases mutant Huntingtin aggregation by targeting Apaf-1 | |
| P478 | volume | 20 |
| Q47149019 | Apoptotic Protease Activating Factor-1 Inhibitor Mitigates Myocardial Ischemia Injury via Disturbing Procaspase-9 Recruitment by Apaf-1. |
| Q38792714 | Discovery of Therapeutic Approaches for Polyglutamine Diseases: A Summary of Recent Efforts |
| Q38259591 | From pathways to targets: understanding the mechanisms behind polyglutamine disease. |
| Q35901927 | Glioma-associated microglial MMP9 expression is upregulated by TLR2 signaling and sensitive to minocycline. |
| Q39274559 | MiR-155 inhibits the sensitivity of lung cancer cells to cisplatin via negative regulation of Apaf-1 expression |
| Q30412597 | Minocycline protection of neomycin induced hearing loss in gerbils |
| Q47144590 | Minocycline treatment increases resistance to oxidative stress and extends lifespan in Drosophila via FOXO. |
| Q37710612 | Minocycline treatment suppresses juvenile development and growth by attenuating insulin/TOR signaling in Drosophila animal model |
| Q92269192 | Neuroprotective Effects of Doxycycline in the R6/2 Mouse Model of Huntington's Disease |
| Q38165760 | Studying neurodegenerative diseases in culture models. |
| Q90552914 | The Involvement of NLRP3 on the Effects of Minocycline in an AD-Like Pathology Induced by β-Amyloid Oligomers Administered to Mice |
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