Apocytochrome c blocks caspase-9 activation and Bax-induced apoptosis

scientific article published on 18 October 2002

Apocytochrome c blocks caspase-9 activation and Bax-induced apoptosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M209369200
P698PubMed publication ID12393884

P50authorHoward O. FearnheadQ39738827
P2093author name stringAngel G Martin
P2860cites workDiva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell deathQ22008056
Boo, a novel negative regulator of cell death, interacts with Apaf-1.Q22008618
Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1Q24290112
PUMA induces the rapid apoptosis of colorectal cancer cellsQ24291462
PUMA, a novel proapoptotic gene, is induced by p53Q24291463
Caspase-10 is an initiator caspase in death receptor signalingQ24291922
Selective inhibitors of apoptotic caspases: implications for novel therapeutic strategiesQ59393051
Expression and functional analysis of Apaf-1 isoforms. Extra Wd-40 repeat is required for cytochrome c binding and regulated activation of procaspase-9Q73561050
Regulation of apoptosis by BH3 domains in a cell-free systemQ73908307
Bacterial expression of a mitochondrial cytochrome c. Trimethylation of lys72 in yeast iso-1-cytochrome c and the alkaline conformational transitionQ74477710
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascadeQ24311006
Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blockedQ24318845
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3Q24324482
Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionalityQ27622605
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machineryQ27860586
Mammalian caspases: structure, activation, substrates, and functions during apoptosisQ28139429
A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosisQ28139969
Negative regulation of the Apaf-1 apoptosome by Hsp70Q28143100
WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activationQ28290389
Apocytochrome c requires the TOM complex for translocation across the mitochondrial outer membraneQ28361325
Bax directly induces release of cytochrome c from isolated mitochondriaQ28588847
A mutational epitope for cytochrome C binding to the apoptosis protease activation factor-1Q28910385
Caspases: enemies withinQ29547315
Two CD95 (APO-1/Fas) signaling pathwaysQ29619631
IAP proteins: blocking the road to death's doorQ29619844
Apoptosis: a potential target for discovering novel therapies for cardiovascular diseasesQ33695709
Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosomeQ33912989
An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson's diseaseQ33943954
Post-cytochrome C protection from apoptosis conferred by a MAPK pathway in Xenopus egg extractsQ33953642
Apoptosis in neurodegenerative disordersQ34186312
Cellular stress response and apoptosis in cancer therapy.Q34417153
Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90Q34487157
Caspase-9 and APAF-1 form an active holoenzymeQ35210359
Cytochrome c binding to Apaf-1: the effects of dATP and ionic strengthQ35350697
Akt regulates cell survival and apoptosis at a postmitochondrial levelQ36342570
Oncogene-dependent apoptosis is mediated by caspase-9.Q36795978
B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathwayQ39446559
Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilizationQ40708852
Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: inhibition by PKB/Akt but not Raf signallingQ40852926
Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat regionQ40941506
Oncogene-dependent apoptosis in extracts from drug-resistant cellsQ41110154
Determinants of cytochrome c pro-apoptotic activity. The role of lysine 72 trimethylationQ41737271
Importance of the redox state of cytochrome c during caspase activation in cytosolic extractsQ42159495
Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in miceQ43977943
Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injuryQ44023078
Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosisQ44028668
Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c.Q46355494
Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation.Q55035703
P433issue52
P407language of work or nameEnglishQ1860
P304page(s)50834-50841
P577publication date2002-10-18
P1433published inJournal of Biological ChemistryQ867727
P1476titleApocytochrome c blocks caspase-9 activation and Bax-induced apoptosis
P478volume277

Reverse relations

cites work (P2860)
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