Stereoselectivity: an issue of significant importance in clinical pharmacology

scientific article published on January 1988

Stereoselectivity: an issue of significant importance in clinical pharmacology is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1002/J.1875-9114.1988.TB04069.X
P698PubMed publication ID3050903

P2093author name stringLam YW
P2860cites workInteraction of clofibrate with warfarin. I. Effect of clofibrate on the disposition of the optical enantiomorphs of warfarinQ58817421
Active Transport of L-Dopa in the IntestineQ59068223
Toxicity and Teratogenicity of Optical Isomers of ThalidomideQ59099301
Untoward effects associated with practolol administration: oculomucocutaneous syndromeQ24674646
Possible role of antibody specific for a practolol metabolite in the pathogenesis of oculomucocutaneous syndromeQ24675553
Effect of verapamil studied by programmed electrical stimulation of the heart in patients with paroxysmal re-entrant supraventricular tachycardiaQ28333056
Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacologyQ34054672
Bronchial beta-adrenoceptor blockade following eyedrops of timolol and its isomer L-714,465 in normal subjectsQ34446748
Plasma levels of (+) and (-)-propranolol and 4-hydroxypropranolol after administration of racemic (+/-)-propranolol in manQ34511604
(+)-Propranolol clearance, an estimation of hepatic blood flow in manQ34516519
Stereoselective renal clearance of pindolol in humansQ34563398
Differentiation of Receptor Systems activated by Sympathomimetic AminesQ34706728
Methadone binding to orosomucoid (alpha 1-acid glycoprotein): determinant of free fraction in plasmaQ34716290
Verapamil in the treatment of paroxysmal supraventricular tachycardiaQ36810365
Simultaneous determination of (–)- and (+)- propranolol by gas chromatography-mass spectrometry using a deuterium labeling techniqueQ39122875
A functional basis for classification of α-adrenergic receptorsQ39165904
Cimetidine: interaction with oral anticoagulants in manQ39559857
The Adrenergic ReceptorQ40044009
Recent advances in methods of direct optical resolutionQ40178235
Serum tocainide enantiomer concentrations in human subjectsQ40210377
Warfarin. Stereochemical aspects of its metabolism and the interaction with phenylbutazoneQ40373479
The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmiasQ41357289
Differential stereoselective metabolism of metoprolol in extensive and poor debrisoquin metabolizersQ41588910
Warfarin metabolism in man: identification of metabolites in urineQ41710726
The alpha- and beta-adrenoceptor blocking potencies of labetalol and its individual stereoisomers in anaesthetized dogs and in isolated tissuesQ41893893
Stereoselective binding of propranolol enantiomers to human alpha 1-acid glycoprotein and human plasmaQ41940414
Stereoselective interaction between the R enantiomer of warfarin and cimetidineQ42073220
The warfarin-cimetidine interaction: stereochemical considerationsQ42074620
A comparison of the cardiovascular effects of (+)-sotalol and (+/-)-sotalol following intravenous administration in normal volunteersQ42077131
Stereoselective first-pass metabolism of highly cleared drugs: studies of the bioavailability of L- and D-verapamil examined with a stable isotope techniqueQ42126042
Phenylbutazone-warfarin interaction in man: further stereochemical and metabolic considerationsQ42246990
Pharmacokinetics of (+)-, (-)- and (+/-)-verapamil after intravenous administrationQ42532060
Modification of Parkinsonism--chronic treatment with L-dopaQ45300970
Treatment of acute focal cerebral ischemia with propranololQ48948936
Effects on atrioventricular conduction and blood flow of enantiomers of verapamil and of tetrodotoxin injected into the posterior and the anterior septal artery of the atrioventricular node preparation of the dogQ52701844
Regional hemodynamic effects of beta-adrenergic blockade with propranolol in the unanesthetized primateQ54653336
Pharmacokinetics and pharmacodynamics of the enantiomers of warfarin in manQ54693988
Cutaneous and ocular reactions to practolol.Q55109534
Immediate Effects of Intravenous Verapamil in Cardiac ArrhythmiasQ55359543
Effects of verapamil on P-R-intervals in relation to verapamil plasma levels following single i.v. and oral administration and during chronic treatmentQ57072042
In vivo interaction of the enantiomers of disopyramide in human subjectsQ58817353
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectstereoselectivityQ903429
P304page(s)147-157
P577publication date1988-01-01
P1433published inPharmacotherapyQ7180800
P1476titleStereoselectivity: an issue of significant importance in clinical pharmacology
P478volume8

Reverse relations

cites work (P2860)
Q36176850A rapid and efficient analytical method for the quantification of a novel anticholinergic compound, R-phencynonate, by stable isotope-dilution LC-MS/MS and its application to bioavailability and dose proportionality studies
Q42032895Age-dependent stereoselective increase in the oral clearance of hexobarbitone isomers caused by rifampicin
Q38758099Dilevalol: a selective beta-2 adrenergic agonist vasodilator with beta adrenergic blocking activity
Q37913132Drug interactions in hypertensive patients. Pharmacokinetic, pharmacodynamic and genetic considerations
Q36138026Drug interactions: Part I
Q44288491High-performance liquid-chromatographic determination of warfarin enantiomers in plasma with automated on-line sample enrichment
Q31115254In vitro assessment of stereoselective hepatic metabolism of disopyramide in humans: Comparison with in vivo data
Q68506534Nonsteroidal anti-inflammatory drugs
Q35871814Sedation and histamine H1-receptor antagonism: studies in man with the enantiomers of chlorpheniramine and dimethindene
Q40858967Stereoselective and isozyme-selective drug interactions
Q34402549Use of pseudoracemic nitrendipine to elucidate the metabolic steps responsible for stereoselective disposition of nitrendipine enantiomers