Pharmacokinetics of (+)-, (-)- and (+/-)-verapamil after intravenous administration

scientific article published on April 1984

Pharmacokinetics of (+)-, (-)- and (+/-)-verapamil after intravenous administration is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1365-2125.1984.TB02371.X
P932PMC publication ID1463390
P698PubMed publication ID6721991
P5875ResearchGate publication ID16476953

P50authorGerd MikusQ37382592
P2093author name stringM Eichelbaum
B Vogelgesang
P2860cites workLinear pharmacokinetic equations allowing direct calculation of many needed pharmacokinetic parameters from the coefficients and exponents of polyexponential equations which have been fitted to the dataQ30558717
Pharmacokinetics, bioavailability and ECG response of verapamil in patients with liver cirrhosisQ34448937
Systemic availability of oral verapamil and effect on PR interval in manQ34449063
Influence of meso-caval shunt surgery on verapamil kinetics, bioavailability and responseQ43242625
Relationship of antiarrhythmic to inotropic activity and antiarrhythmic qualities of the optical isomers of verapamilQ46842897
Nonlinear least-squares regression programs for microcomputersQ52231910
Simultaneous determination of the intravenous and oral pharmacokinetic parameters of D,L-verapamil using stable isotope-labelled verapamil.Q52435676
Effects on atrioventricular conduction and blood flow of enantiomers of verapamil and of tetrodotoxin injected into the posterior and the anterior septal artery of the atrioventricular node preparation of the dogQ52701844
Verapamil kinetics in normal subjects and patients with coronary artery spasmQ52733119
Determination of verapamil in human plasma by mass fragmentography using stable isotope-labelled verapamil as internal standardQ52821925
Physiological disposition of verapamil in manQ57072038
Effects of verapamil on P-R-intervals in relation to verapamil plasma levels following single i.v. and oral administration and during chronic treatmentQ57072042
The pharmacology of verapamil. IV. Kinetic and dynamic effects after single intravenous and oral dosesQ70283797
Clinical pharmacokinetics of verapamil in patients with atrial fibrillationQ70478662
Comparison of intravenous and oral verapamil dosingQ70509532
Superiority of stable isotope techniques in the assessment of the bioavailability of drugs undergoing extensive first pass elimination. Studies of the relative bioavailability of verapamil tabletsQ70681056
Verapamil disposition kinetics in chronic atrial fibrillationQ70791160
Direct determination of hepatic extraction of verapamil in cardiac patientsQ70791163
Effects of verapamil and its optical isomers on repetitive slow responses induced by electrical depolarization in canine ventricular myocardiumQ71189953
Verapamil disposition in liver disease and intensive-care patients: kinetics, clearance, and apparent blood flow relationshipsQ71472633
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectpharmacokineticsQ323936
P304page(s)453-458
P577publication date1984-04-01
P1433published inBritish Journal of Clinical PharmacologyQ176044
P1476titlePharmacokinetics of (+)-, (-)- and (+/-)-verapamil after intravenous administration
P478volume17

Reverse relations

cites work (P2860)
Q40633547(R)- and (S)-[11C]verapamil as PET-tracers for measuring P-glycoprotein function: in vitro and in vivo evaluation.
Q42585832A combined accelerator mass spectrometry-positron emission tomography human microdose study with 14C- and 11C-labelled verapamil.
Q41180399A comparative review of the adverse effects of calcium antagonists
Q54191138A phase I trial of intrahepatic verapamil and doxorubicin. Regional therapy to overcome multidrug resistance.
Q40359652A physiologically based pharmacokinetic model to predict the pharmacokinetics of highly protein-bound drugs and the impact of errors in plasma protein binding
Q47285157A semi-automated method for the integrated evaluation of half-life and metabolic soft spots of discovery compounds
Q73073722Achiral and chiral high-performance liquid chromatography of verapamil and its metabolites in serum samples
Q34347537Age and gender related changes in stereoselective pharmacokinetics and pharmacodynamics of verapamil and norverapamil
Q36947632Age dependency of cerebral P-gp function measured with (R)-[11C]verapamil and PET.
Q68631795Analysis of drugs and other toxic substances in biological samples for pharmacokinetic studies
Q36517093Applications of minimal physiologically-based pharmacokinetic models
Q41565334Bioequivalence of chiral drugs. Stereospecific versus non-stereospecific methods
Q56832288Cardiovascular effects of (R)- and (S)-verapamil and racemic verapamil in humans: a placebo-controlled study
Q36705746Chiral aspects of drug action at ion channels: A commentary on the stereoselectivity of drug actions at voltage-gated ion channels with particular reference to verapamil actions at the Ca2+ channel
Q36820837Chiral stereoisomeric molecules in the treatment of arthritis
Q38679209Chirality: pharmacokinetics and pharmacodynamics in 3 dimensions
Q36115910Clinical pharmacokinetics of calcium antagonists. An update
Q39754378Clinical pharmacokinetics of verapamil, nifedipine and diltiazem
Q68019659Column-switching high-performance liquid chromatography for on-line simultaneous determination and resolution of enantiomers of verapamil and its metabolites
Q71267288Determination of R(+)- and S(-)-lansoprazole using chiral stationary-phase liquid chromatography and their enantioselective pharmacokinetics in humans
Q58860170Determination of salbutamol enantiomers by high-performance capillary electrophoresis and its application to dissolution assays
Q42807085Development of 2D chiral chromatography with accelerator mass spectrometry for quantification of (14)C-labeled R- and S-verapamil in plasma.
Q36582463Drug disposition in three dimensions: an update on stereoselectivity in pharmacokinetics
Q46955216Effect of naringin pretreatment on bioavailability of verapamil in rabbits
Q34597408Effect of pioglitazone on the pharmacokinetics of verapamil and its major metabolite, norverapamil, in rats
Q42138751Effects of calcium channel blockers on the development of early rat postimplantation embryos in culture
Q43246010Effects of lovastatin on the pharmacokinetics of verapamil and its active metabolite, norverapamil in rats: possible role of P-glycoprotein inhibition by lovastatin
Q43158040Effects of simvastatin on the pharmacokinetics of verapamil and its main metabolite, norverapamil, in rats
Q40087720Enantioselective disposition of ofloxacin in humans
Q56832394Enantioselective gallopamil protein binding
Q47678802Enantioselective tissue distribution of the basic drugs disopyramide, flecainide and verapamil in rats: role of plasma protein and tissue phosphatidylserine binding
Q46617166Enhanced bioavailability of verapamil after oral administration with hesperidin in rats
Q43204832Evaluation of potential pharmacodynamic and pharmacokinetic interactions between verapamil and propranolol in normal subjects
Q54152616Fully automated high yield synthesis of (R)- and (S)-[11C]verapamil for measuring P-glycoprotein function with positron emission tomography
Q35802166Gut wall metabolism of verapamil in older people: effects of rifampicin-mediated enzyme induction
Q46706108Identification of intestinal loss of a drug through physiologically based pharmacokinetic simulation of plasma concentration-time profiles
Q34725737Impact of stereoselectivity on the pharmacokinetics and pharmacodynamics of antiarrhythmic drugs
Q39834900Importance of drug enantiomers in clinical pharmacology
Q37544345Molecular asymmetry and its pharmacological consequences
Q38023576New concepts affecting the use of antiarrhythmic agents
Q52262360New mathematical implementation of generalized pharmacodynamic models: method and clinical evaluation.
Q37742565Nonlinear pharmacokinetics: clinical Implications
Q36953090PET and SPECT radiotracers to assess function and expression of ABC transporters in vivo
Q34396966Pharmacokinetic evaluation in man of terbutaline given as separate enantiomers and as the racemate
Q35976246Pharmacokinetic interaction between epirubicin and the multidrug resistance reverting agent D-verapamil
Q39662361Pharmacokinetic interactions of cimetidine 1987.
Q42005077Pharmacokinetics and pharmacodynamics of verapamil following sublingual and oral administration to healthy volunteers
Q28282551Pharmacokinetics of (+)-rolipram and (-)-rolipram in healthy volunteers
Q64885687Pharmacokinetics of S(+)- and R(-)-ibuprofen in volunteers and first clinical experience of S(+)-ibuprofen in rheumatoid arthritis.
Q39513598Pharmacokinetics of calcium antagonists under development
Q43916480Pharmacokinetics of controlled-release verapamil in healthy volunteers and patients with hypertension or angina.
Q41095274Pharmacokinetics of the enantiomers of verapamil in the dog.
Q46511734Pharmacokinetics of verapamil and its major metabolite, norverapamil from oral administration of verapamil in rabbits with hepatic failure induced by carbon tetrachloride
Q69720626Pharmacokinetics of verapamil in patients with hypertension
Q51250114Prediction of hepatic plasma clearance in vivo from gel-entrapped rat and human hepatocytes.
Q77331770Properties of the racemic species of verapamil hydrochloride and gallopamil hydrochloride
Q48420233Quantitative determination of disopyramide, verapamil and flecainide enantiomers in rat plasma and tissues by high-performance liquid chromatography.
Q43554159Race but not age affects erythromycin breath test results in older hypertensive men.
Q36003980Relationship between the stereoselective negative inotropic effects of verapamil enantiomers and their binding to putative calcium channels in human heart
Q43222574Serum binding of nifedipine and verapamil in patients with ischaemic heart disease on monotherapy
Q72598322Simple and reliable radioreceptor assay for beta-adrenoceptor antagonists and active metabolites in native human plasma
Q40529605Stereochemistry in pharmacotherapy: when mirror images are not identical
Q39746510Stereochemistry: a source of problems in medicinal chemistry
Q34447697Stereoselective disposition of mexiletine in man
Q42126042Stereoselective first-pass metabolism of highly cleared drugs: studies of the bioavailability of L- and D-verapamil examined with a stable isotope technique
Q73204587Stereoselective metabolism of famprofazone in humans: N-dealkylation and beta- and p-hydroxylation
Q45720989Stereoselective plasma protein binding of ibuprofen enantiomers
Q40832872Stereoselectivity in S- and N-oxygenation by the mammalian flavin-containing and cytochrome P-450 monooxygenases
Q37946823Stereoselectivity in clinical pharmacokinetics and drug development
Q37229338Stereoselectivity in pharmacokinetics: a general theory
Q39529348Stereoselectivity: an issue of significant importance in clinical pharmacology
Q40458699The Genetic Basis of Resistance to Cancer Chemotherapy
Q45162718The effect of quercetin on the pharmacokinetics of verapamil and its major metabolite, norverapamil, in rabbits
Q44862793The influence of cimetidine on the pharmacokinetics of the enantiomers of verapamil in the dog during multiple oral dosing
Q34191085The mechanism of action of the optical enantiomers of verapamil against ischaemia-induced arrhythmias in the conscious rat.
Q68859240The pharmacokinetics of d-sotalol and d,l-sotalol in healthy volunteers
Q53763140The stereoselectivity of the 'single drug binding site' of human alpha 1-acid glycoprotein (orosomucoid).
Q35170048Therapeutic drug monitoring of antiarrhythmic drugs
Q37909320Therapeutic drug monitoring of antiarrhythmic drugs. Rationale and current status
Q30858015Thin-layer chromatography separation of enantiomers of verapamil using macrocyclic antibiotic as a chiral selector
Q51586621Verapamil stereoisomerism: Enantiomeric ratios in plasma dependent on peak concentrations, oral input rate, or both*
Q38679740Verapamil. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension

Search more.