scholarly article | Q13442814 |
review article | Q7318358 |
P6179 | Dimensions Publication ID | 1023180561 |
P356 | DOI | 10.2165/00003495-198530040-00003 |
P698 | PubMed publication ID | 3905334 |
P2093 | author name string | E Lee | |
K Williams | |||
P2860 | cites work | The binding of the optical isomers of methadone, alpha-methadol, alpha-acetylmethadol and their N-demethylated derivatives to the opiate receptors of rat brain | Q28259252 |
Effects of pretreatment with phenobarbitone and phenytoin on the pharmacokinetics and toxicity of phenytoin on the pharmacokinetics and toxicity of misonidazole in mice | Q28328476 | ||
Stereoselective interaction of phenylbutazone with [12C/13C]warfarin pseudoracemates in man | Q28367057 | ||
Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacology | Q34054672 | ||
Pathways of metabolism of amphetamine and related compounds | Q34180095 | ||
Indacrinone: natriuretic and uricosuric effects of various ratios of its enantiomers in healthy men. | Q34262466 | ||
Plasma levels of (+) and (-)-propranolol and 4-hydroxypropranolol after administration of racemic (+/-)-propranolol in man | Q34511604 | ||
Stereoselective disposition of ibuprofen enantiomers in man | Q34622724 | ||
Altered Hepatic Blood Flow and Drug Disposition1 | Q35372340 | ||
Enzyme Reaction Stereospecificity: A Critical Revie | Q38362449 | ||
Pharmacological differences between the optical isomers of ibuprofen: evidence for metabolic inversion of the (—)-isomer | Q39099127 | ||
Stereospecific binding of timolol, a beta-adrenergic blocking agent | Q39107584 | ||
Stereoselective inversion of (R)-(-)-benoxaprofen to the (S)-(+)-enantiomer in humans | Q39296647 | ||
A critical evaluation of the application of amino acid racemization to geochronology and geothermometry | Q39709399 | ||
Optical resolution of some homobenzomorphan derivatives and their pharmacological properties | Q39712415 | ||
Epimers of moxalactam: in vitro comparison of activity and stability | Q39855402 | ||
Determination of moxalactam in human body fluids by liquid chromatographic and microbiological methods | Q39855613 | ||
Stereoisomerism and drug action in the nervous system | Q39873275 | ||
Molecular geometry and adrenergic drug activity. | Q39875629 | ||
The influence of stereochemical factors on drug disposition | Q39881489 | ||
Steric aspects of adrenergic drugs | Q39905881 | ||
The metabolic chiral inversion of 2-arylpropionic acids—a novel route with pharmacological consequences | Q40092311 | ||
Mechanism of Action of Barbiturates | Q40124760 | ||
Interrelationships between xenobiotic metabolism and lipid biosynthesis | Q40153015 | ||
Recent advances in methods of direct optical resolution | Q40178235 | ||
Noninvasive chemical methods of estimating pharmacokinetic parameters | Q40253387 | ||
High stereospecificity of the benzodiazepine binding site on human serum albumin. Studies with d- and l-oxazepam hemisuccinate | Q40310010 | ||
Warfarin. Stereochemical aspects of its metabolism and the interaction with phenylbutazone | Q40373479 | ||
Side effects of levomethadone and racemic methadone in a maintenance program | Q41048216 | ||
Antimalarial activity of the optical isomers of chloroquine diphosphate | Q41183025 | ||
The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias | Q41357289 | ||
Differential stereoselective metabolism of metoprolol in extensive and poor debrisoquin metabolizers | Q41588910 | ||
Stereoselective disposition of methadone in man. | Q41642344 | ||
Stereoselective oral bioavailability of (+/-)-propranolol in the dog. A GC-MS study using a stable isotope technique | Q41709229 | ||
Racemic Warfarin and Trimethoprim-Sulfamethoxazole Interaction in Humans | Q41721065 | ||
Stereoselective binding of propranolol enantiomers to human alpha 1-acid glycoprotein and human plasma | Q41940414 | ||
Comparative pharmacokinetics of coumarin anticoagulants XXXVI: Predicted steady-state patterns of prothrombin complex activity produced by equieffective doses of (R)-(+)- and (S)-(-)-warfarin in humans | Q41957399 | ||
Pharmacokinetics of the enantiomers of acenocoumarol in man | Q42048596 | ||
Stereoselective first-pass metabolism of highly cleared drugs: studies of the bioavailability of L- and D-verapamil examined with a stable isotope technique | Q42126042 | ||
Stereoselective inversion of (R)-fenoprofen to (S)-fenoprofen in humans | Q42225734 | ||
Phenylbutazone-warfarin interaction in man: further stereochemical and metabolic considerations | Q42246990 | ||
Studies on the optical enantiomorphs of warfarin in man | Q69355706 | ||
The hemodynamic effects of beta adrenergic blockade on the flow-dependent hepatic clearance of propranolol | Q69381509 | ||
Some comparative effects of racemic methadone and its optical isomers in rodents | Q69764722 | ||
Stereoselective disposition--basis for variability in response to NSAID's | Q69853636 | ||
Analgesic and other effects of the d- and l-isomers of penzocine | Q69880676 | ||
The disposition of propranolol. 8. General implications of the effects of liver blood flow on elimination from the perfused rat liver | Q70043133 | ||
Stereoselective interaction of sulfinpyrazone with racemic warfarin and its separated enantiomorphs in man | Q70263948 | ||
Drug interactions with warfarin | Q70268807 | ||
Quantitation of methadone enantiomers in humans using stable isotope-labeled [2H3]-, [2H5]-, and [2H8]Methadone | Q70274771 | ||
Enantiomers of indacrinone: a new approach to producing an isouricemic diuretic | Q70334319 | ||
Oxidation of (R)- and (S)-propranolol in human and dog liver microsomes. Species differences in stereoselectivity | Q70406123 | ||
Ticrynafen-racemic warfarin interaction: hepatotoxic or stereoselective? | Q70425480 | ||
The importance of stereochemistry in the clinical pharmacokinetics of the 2-arylpropionic acid non-steroidal anti-inflammatory drugs | Q70584608 | ||
Stereoselective binding of disopyramide to human plasma protein | Q70626111 | ||
Pharmacokinetics of the enantiomers of indoprofen in man | Q70647051 | ||
Kinetics of misonidazole enantiomers | Q70670632 | ||
Stereospecific inversion of (R)-(-)-benoxaprofen in rat and man | Q70680959 | ||
Pharmacokinetic implications of stereoselective changes in plasma-protein binding: warfarin/sulfinpyrazone | Q70738455 | ||
Pharmacology of enantiomers and (–) p-OH metabolite of indacrinone | Q70758053 | ||
No stereoselective first-pass hepatic extraction of propranolol | Q70904334 | ||
Comparative interaction of sulfinpyrazone and phenylbutazone with racemic warfarin: alteration in vivo of free fraction of plasma warfarin | Q70978535 | ||
Effect of Pentobarbital on the Formation of Diastereomeric Oxazepam Glucuronides in Man: Analysis by High Performance Liquid Chromatography | Q71093508 | ||
Stereoselective binding of propranolol to human plasma, alpha 1-acid glycoprotein, and albumin | Q71098357 | ||
Stereoselective interaction of trimethoprim-sulfamethoxazole with the separated enantiomorphs of racemic warfarin in man | Q71128161 | ||
Effects of verapamil and its optical isomers on repetitive slow responses induced by electrical depolarization in canine ventricular myocardium | Q71189953 | ||
Entero-hepatic cycling of methotrexate estimated by use of the D-isomer as a reference marker | Q71324283 | ||
Stereospecific assay for (-)- and (+)-propranolol in human and dog plasma | Q71404946 | ||
The effect of d-timolol on intraocular pressure in patients with ocular hypertension | Q71415526 | ||
Effects of enantiomers of indacrinone (MK-196) on cation transport by the loop of Henle and distal tubule studied by microperfusion in vivo | Q71434284 | ||
Propranolol and essential tremor: rôle of the membrane effect | Q71450335 | ||
Dynamic interaction between disulfiram and separated enantiomorphs of racemic warfarin | Q71509185 | ||
Enhancement of uricosuric properties of indacrinone by manipulation of the enantiomer ratio | Q71509193 | ||
Effects of phenytoin, phenobarbital, and ascorbic acid on misonidazole elimination | Q71662476 | ||
High-performance liquid chromatographic determination of stereoselective disposition of carprofen in humans | Q72097547 | ||
Potentiation of anticoagulant effect of warfarin by phenylbutazone | Q72204481 | ||
Potentiation of warfarin action by sulphinpyrazone | Q72419029 | ||
Sulphinpyrazone and warfarin: a probable drug interaction | Q72420477 | ||
Stereoselectivity in the disposition and metabolism of the uricosuric-diuretic agent, indacrinone, in Rhesus monkeys | Q72529868 | ||
Stereoselective binding of the (-)-enantiomer of propranolol to plasma and extravascular binding sites in the dog | Q72561779 | ||
The specific binding of L-tryptophan to serum albumin | Q78478028 | ||
Separation of morphine-like effects by optical resolution. Levo isomers as strong analgetics and narcotic antagonists | Q93788343 | ||
Optical isomers of miscellaneous strong analgetics | Q93808036 | ||
Stereochemical aspects of para-chloroamphetamine metabolism. Rabbit liver microsomal metabolism of RS-, R(-)-. and S(+)-para-chloroamphetamine | Q42263315 | ||
Interaction of secobarbital with warfarin pseudoracemates | Q42272532 | ||
Pharmacokinetics of (+)-, (-)- and (+/-)-verapamil after intravenous administration | Q42532060 | ||
Single dose pharmacokinetics and bioavailability of methadone in man studied with a stable isotope method | Q42671123 | ||
Anticoagulant activity of the enantiomers of acenocoumarol | Q43251820 | ||
Methadone in man: Pharmacokinetic and excretion studies in acute and chronic treatment | Q43415761 | ||
Benzodiazepines: specific competitors for the binding of L-tryptophan to human serum albumin | Q43805157 | ||
Observations on the differential metabolism and biological activity of the optical isomers of cyclophosphamide | Q43988051 | ||
Commentary: a physiological approach to hepatic drug clearance | Q43996648 | ||
Present status of enantiomeric analysis by gas chromatography | Q44357688 | ||
The disposition of propranolol. VII. The effects of saturable hepatic tissue uptake on drug clearance by the perfused rat liver | Q44386068 | ||
Cerebral protection with barbiturates: relation to anesthetic effect | Q44853861 | ||
Modification of Parkinsonism--chronic treatment with L-dopa | Q45300970 | ||
Possible interaction of sulfinpyrazone with coumarins | Q46613900 | ||
Relationship of antiarrhythmic to inotropic activity and antiarrhythmic qualities of the optical isomers of verapamil | Q46842897 | ||
Effect of l-propoxyphene on plasma levels and analgesic activity of d-propoxyphene in the rat. | Q48354306 | ||
Treatment of acute focal cerebral ischemia with propranolol | Q48948936 | ||
Absorption, distribution and toxicity of ibuprofen | Q51160157 | ||
Respiratory and subjective effects of dand l-pentazocine. | Q51340760 | ||
Stereospecific salivary excretion of tocainide enantiomers in man. | Q51848465 | ||
Kinetics of microsomal metabolism and binding of enantiomerically related substrates. | Q53798353 | ||
Studies on the interaction of warfarin and clofibrate in man. | Q54483209 | ||
Coronary vasodilator and cardiac effects of optical isomers of verapamil in the dog. | Q54563735 | ||
Regional hemodynamic effects of beta-adrenergic blockade with propranolol in the unanesthetized primate | Q54653336 | ||
Pharmacokinetics and pharmacodynamics of the enantiomers of warfarin in man | Q54693988 | ||
Effects of verapamil on P-R-intervals in relation to verapamil plasma levels following single i.v. and oral administration and during chronic treatment | Q57072042 | ||
Liquid Chromatographic Determination and Plasma Concentration Profile of Optical Isomers of Ibuprofen in Humans | Q57415363 | ||
Interaction of clofibrate with warfarin. I. Effect of clofibrate on the disposition of the optical enantiomorphs of warfarin | Q58817421 | ||
Active Transport of L-Dopa in the Intestine | Q59068223 | ||
Chromatographic resolution of enantiomers selective review | Q66902935 | ||
Effects of phenylbutazone, tolbutamide, and clofibric acid on binding of racemic warfarin and its enantiomers to human serum albumin | Q66986044 | ||
Pharmacokinetics of warfarin enantiomers: A search for intrasubject correlations | Q67250003 | ||
The disposition of propranolol. 3. Decreased half-life and volume of distribution as a result of plasma binding in man, monkey, dog and rat | Q67251918 | ||
The participation of ethyl 4-benzyloxybenzoate (BRL 10894) and other aryl-substituted acids in glycerolipid metabolism | Q67253777 | ||
The metabolism of ibuprofen | Q67267970 | ||
Inotropic and electrophysiological actions of verapamil and D 600 in mammalian myocardium. III. Effects of the optical isomers on transmembrane action potentials | Q67317634 | ||
Comparative Pharmacokinetics of Coumarin Anticoagulants XIV: Relationship between Protein Binding, Distribution, and Elimination Kinetics of Warfarin in Rats | Q67341246 | ||
Optical isomers of verapamil on canine heart. Prevention of ventricular fibrillation induced by coronary artery occlusion, impaired atrioventricular conductance and negative inotropic and chronotropic effects | Q67358648 | ||
Serum protein binding as a determinant of warfarin body clearance and anticoagulant effect | Q67462261 | ||
Optical studies on the mechanism of the interaction of the enantiomers of the antiocagulant drugs phenprocoumon and warfarin with human serum albumin | Q67542817 | ||
Clinical effects and pharmacokinetics of racemic methadone and its optical isomers | Q67548895 | ||
Protein binding of warfarin enantiomers in serum of humans and rats | Q67571004 | ||
The metabolism and antitumour activity of the enantiomers of cis- and trans-4-methylcyclophosphamide | Q67652806 | ||
The stereoselective interaction of warfarin and metronidazole in man | Q67745717 | ||
Stereospecific radioimmunoassay for propranolol isomers | Q67759023 | ||
The enantiomers of phenprocoumon: pharmacodynamic and pharmacokinetic studies | Q67785438 | ||
The relation between biological activity and the degree of resolution of optical isomers | Q68768503 | ||
P433 | issue | 4 | |
P921 | main subject | pharmacology | Q128406 |
enantiomer | Q494483 | ||
P304 | page(s) | 333-354 | |
P577 | publication date | 1985-10-01 | |
P1433 | published in | Drugs | Q3040094 |
P1476 | title | Importance of drug enantiomers in clinical pharmacology | |
P478 | volume | 30 |
Q41565534 | (S)-Oxiracetam is the Active Ingredient in Oxiracetam that Alleviates the Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion in Rats |
Q53217992 | A dispersive liquid-liquid microextraction and chiral separation of carvedilol in human plasma using capillary electrophoresis. |
Q36176850 | A rapid and efficient analytical method for the quantification of a novel anticholinergic compound, R-phencynonate, by stable isotope-dilution LC-MS/MS and its application to bioavailability and dose proportionality studies |
Q37985855 | A review of the physiological bases of the anorexic action of phenylpropanolamine (d,1-norephedrine). |
Q40080180 | Absolute configuration of beer's bitter compounds. |
Q44388238 | Albendazole sulphoxide enantiomers in pregnant rats' embryo concentrations and developmental toxicity |
Q71455369 | Albumin binding sites for etodolac enantiomers |
Q37127629 | An Enantiomer of an Oral Small-Molecule TSH Receptor Agonist Exhibits Improved Pharmacologic Properties |
Q68631795 | Analysis of drugs and other toxic substances in biological samples for pharmacokinetic studies |
Q36806955 | Bioequivalence of two tablet formulations of nadolol using single and multiple dose data: assessment using stereospecific and nonstereospecific assays |
Q86399673 | Chiral Pool-Based Synthesis of Naphtho-Fused Isocoumarins |
Q77323711 | Chiral high-performance liquid chromatographic analysis of enantiomers of losigamone, a new candidate antiepileptic drug |
Q30991436 | Chiral resolution of flurbiprofen and ketoprofen enantiomers by HPLC on a glycopeptide-type column chiral stationary phase |
Q33232408 | Chiral separation by high performance liquid chromatography. I. Review on indirect separation of enantiomers as diastereomeric derivatives using ultraviolet, fluorescence and electrochemical detection |
Q90660546 | Chiral separation of diastereomers of the cyclic nonapeptides vasopressin and desmopressin by uniform field ion mobility mass spectrometry |
Q36820837 | Chiral stereoisomeric molecules in the treatment of arthritis |
Q37973723 | Chirality and anaesthetic drugs: A review and an update |
Q48027985 | Chirality and neuropsychiatric drugs: an update on stereoselective disposition and clinical pharmacokinetics of bupropion |
Q40579187 | Chirality in new drug development. Clinical pharmacokinetic considerations |
Q37920866 | Chirality. Clinical pharmacokinetic and pharmacodynamic considerations |
Q38730316 | Clinical pharmacokinetic considerations in the elderly. An update |
Q37290795 | Clinical pharmacokinetics and kinetic-dynamic relationships of dilevalol and labetalol |
Q39463386 | Clinical pharmacokinetics of beta-adrenoceptor antagonists. An update |
Q38235680 | Clinical pharmacology and use of nonsteroidal anti-inflammatory drugs. |
Q34358841 | Clinical pharmacology through the looking glass: reflections on the racemate vs enantiomer debate |
Q67928918 | Comparison of the rat liver microsomal metabolism of the enantiomers of warfarin and 4′-nitrowarfarin (Acenocoumarol) |
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Q69026230 | Determination of the enantiomeric composition of ibuprofen in human plasma by high-performance liquid chromatography |
Q68781928 | Determination of the enantiomers of suprofen and [2H3]suprofen in plasma by capillary gas chromatography-mass spectrometry |
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Q77206217 | Effect of clofibrate on the chiral inversion of ibuprofen in healthy volunteers |
Q73163251 | Effects of disopyramide and verapamil on renal disposition and nephrotoxicity of cisplatin in rats |
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Q70553440 | Enantioselective pharmacokinetics of dl-threo-methylphenidate in humans |
Q45156161 | Enantioselective pharmacokinetics of homochlorcyclizine. II: Disposition and metabolism of (+)-, (-)- and racemic homochlorcyclizine after oral administration to man. |
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Q51921628 | Human pharmacokinetics and interconversion of enantiomers of MK-0767, a dual PPARalpha/gamma agonist. |
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Q68743123 | Influence of dose and route of administration on the kinetics of fluoxetine and its metabolite norfluoxetine in the rat |
Q47234727 | Influence of oxytetracycline on carprofen pharmacodynamics and pharmacokinetics in calves |
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Q69462559 | Mephenytoin stereoselective elimination in the rat: II. Comparison of mephenytoin stereoselective clearance during chronic intravenous and hepatic portal vein administration |
Q77505222 | Methamphetamine--properties and analytical methods of enantiomer determination |
Q37544345 | Molecular asymmetry and its pharmacological consequences |
Q43510422 | Optical resolution and absolute configuration of a nonsteroidal antiinflammatory drug, 2-(10,11-dihydro-10-oxodibenzo- [b,f]thiepin-2-yl)propionic acid |
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Q71189979 | Pharmacodynamics and chiral pharmacokinetics of carprofen in calves |
Q44741967 | Pharmacokinetic interactions of cefprozil with food, propantheline, metoclopramide, and probenecid in healthy volunteers |
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Q56620130 | Pharmacokinetics and Metabolism of Bisoprolol Enantiomers in Humans |
Q68372040 | Pharmacokinetics of Ketoprofen Enantiomers in Young and Elderly Arthritic Patients following Single and Multiple Doses |
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