Stereoselective pharmacokinetics of ifosfamide in male and female rats

scientific article published on January 2000

Stereoselective pharmacokinetics of ifosfamide in male and female rats is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1208/PS020217
P932PMC publication ID2751031
P698PubMed publication ID11741233
P5875ResearchGate publication ID225777600

P2093author name stringH Lu
J J Wang
K K Chan
P2860cites workPharmacokinetics of ifosfamide and its enantiomers following a single 1 h intravenous infusion of the racemate in patients with small cell lung carcinomaQ34347516
Ifosfamide clinical pharmacokineticsQ34726639
Chirality. Clinical pharmacokinetic and pharmacodynamic considerationsQ37920866
Enantioselective aspects of drug action and disposition: therapeutic pitfallsQ38725198
Importance of drug enantiomers in clinical pharmacologyQ39834900
Stereospecific synthesis of chiral metabolites of ifosfamide and their determination in the urineQ42259368
Analysis of ifosfamide, 4-hydroxyifosfamide, N2-dechloroethylifosfamide, N3-dechloroethylifosfamide and iphosphoramide mustard in plasma by gas chromatography-mass spectrometryQ46281480
Preclinical pharmacokinetics and stability of isophosphoramide mustardQ46467130
A simple integrated method for drug and derived metabolite kinetics. An application of the statistical moment theoryQ52716803
Role of cytochrome P450 in oxazaphosphorine metabolism. Deactivation via N-dechloroethylation and activation via 4-hydroxylation catalyzed by distinct subsets of rat liver cytochromes P450Q58483717
Activation of the anti-cancer drug ifosphamide by rat liver microsomal P450 enzymesQ58483760
Role of CYP2B6 and CYP3A4 in the in vitro N-dechloroethylation of (R)- and (S)-ifosfamide in human liver microsomesQ64864256
Nonlinear disposition of intravenous 2',3'-dideoxyinosine in ratsQ67562012
Urinary excretion of the enantiomers of ifosfamide and its inactive metabolites in childrenQ68033255
Enantiomers of cyclophosphamide and iphosphamideQ68254991
Dechloroethylation of ifosfamide and neurotoxicityQ69889353
The N-dechloroethylation of ifosfamide: using stereochemistry to obtain an accurate picture of a clinically relevant metabolic pathwayQ70866618
Stereoselective pharmacokinetics of ifosfamide and its 2- and 3-N-dechloroethylated metabolites in female cancer patientsQ70997301
Enantioselective distribution of verapamil and norverapamil into human and rat erythrocytes: the role of plasma protein bindingQ71730856
Efficacy and toxicity of ifosfamide stereoisomers in an in vivo rat mammary carcinoma modelQ72092510
Ifosfamide enantiomers: pharmacokinetics in childrenQ72149453
Determination of the enantiomers of ifosfamide and its 2- and 3-N-dechloroethylated metabolites in plasma and urine using enantioselective gas chromatography with mass spectrometric detectionQ72273021
Influence of phenobarbital induction on the enantioselective N-dechloroethylation of ifosfamide enantiomers in the ratQ72345031
Ifosfamide stereoselective dichloroethylation and neurotoxicityQ72674801
Phenytoin-induced alteration in the N-dechloroethylation of ifosfamide stereoisomersQ73793468
Effects of phenobarbital on stereoselective metabolism of ifosfamide in ratsQ74507414
P433issue2
P921main subjectstereoselectivityQ903429
pharmacokineticsQ323936
ifosfamideQ418560
P304page(s)E17
P577publication date2000-01-01
P1433published inAAPS PharmSciQ26839729
P1476titleStereoselective pharmacokinetics of ifosfamide in male and female rats
P478volume2

Reverse relations

Q38134859Gender-dependent differences in uridine 5'-diphospho-glucuronosyltransferase have implications in metabolism and clearance of xenobioticscites workP2860