Preclinical pharmacokinetics and stability of isophosphoramide mustard

scientific article published in January 1994

Preclinical pharmacokinetics and stability of isophosphoramide mustard is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S002800050071
P8608Fatcat IDrelease_vagzksccnvdzdimosxpj2akigi
P698PubMed publication ID8306413

P50authorFranco MuggiaQ30512486
P2093author name stringK K Chan
J J Zheng
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Isophosphoramide mustard, a metabolite of ifosfamide with activity against murine tumours comparable to cyclophosphamideQ36047370
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Blood levels of alkylating metabolites of cyclophosphamide in the mouse after iv or oral administrationQ41429850
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Accelerated decomposition of 4-hydroxycyclophosphamide by human serum albumin.Q54137859
Isolation and mass spectral identification of blood metabolities of cyclophosphamide: Evidence for phosphoramide mustard as the biologically active metaboliteQ66931110
Identification of phosphorodiamidic acid mustard as a human metabolite of cyclop hosphamideQ66931794
Quantitation by gas chromatography-chemical ionization mass spectrometry of cyclophosphamide, phosphoramide mustard, and nornitrogen mustard in the plasma and urine of patients receiving cyclophosphamide therapyQ67249744
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A biologically active metabolite of cyclophosphamideQ69500918
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Bioassay and relative cytotoxic potency of cyclophosphamide metabolites generated in vitro and in vivoQ69551574
Some studies of the active intermediates formed in the microsomal metabolism of cyclophosphamide and isophosphamideQ69733875
Plasma concentrations of 4-hydroxycyclophosphamide and phosphoramide mustard in patients repeatedly given high doses of cyclophosphamide in preparation for bone marrow transplantationQ70412322
Comparative in vitro cytotoxicity of cyclophosphamide, its major active metabolites and the new oxazaphosphorine ASTA Z 7557 (INN mafosfamide)Q70589430
Observations on the effects of cyclophosphamide, phosphoramide mustard and some activated oxazaphosphorines on murine L1210 leukemiaQ70589434
Effect of damaged liver parenchyma, renal insufficiency and hemodialysis on the pharmacokinetics of cyclophosphamide and its activated metabolitesQ70657594
Comparative study on human pharmacokinetics of activated ifosfamide and cyclophosphamide by a modified fluorometric testQ70797964
Simple reliable method for chronic cannulation of the jugular vein for pharmacokinetic studies in ratsQ71074108
Comparison of cytotoxic action of iphosphamide and cyclophosphamideQ71110478
Kinetics of cyclophosphamide biotransformation in vivoQ71127536
[Blood level and urinary excretion of activated cyclophosphamide and its deactivation products in man (author's transl)]Q71143704
Quantification by gas chromatography of N,N'-di-(2-chloroethyl)-phosphorodiamidic acid in the plasma of patients receiving isophosphamideQ71393836
Cytotoxic activity relative to 4-hydroxycyclophosphamide and phosphoramide mustard concentrations in the plasma of cyclophosphamide-treated ratsQ71661503
Clinical toxicologic study of cyclohexylamine salt of N,N-bis(2-chlorethyl)phosphorodiamidic acid (NSC-69945; OMF-59)Q72255780
Disposition of enalapril and its diacid metabolite, enalaprilat, in a perfused rat liver preparation. Presence of a diffusional barrier for enalaprilat into hepatocytesQ72581661
Half-life of oxazaphosphorines in biological fluidsQ72592442
P433issue5
P921main subjectpharmacokineticsQ323936
P304page(s)391-398
P577publication date1994-01-01
P1433published inCancer Chemotherapy and PharmacologyQ326137
P1476titlePreclinical pharmacokinetics and stability of isophosphoramide mustard
P478volume33

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cites work (P2860)
Q60924205An Intratumor Pharmacokinetic/Pharmacodynamic Model for the Hypoxia-Activated Prodrug Evofosfamide (TH-302): Monotherapy Activity is Not Dependent on a Bystander Effect
Q27000814Extravascular use of drug-eluting beads: a promising approach in compartment-based tumor therapy
Q37361514Stereoselective pharmacokinetics of ifosfamide in male and female rats

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