Disposition of enalapril and its diacid metabolite, enalaprilat, in a perfused rat liver preparation. Presence of a diffusional barrier for enalaprilat into hepatocytes

scientific article published on 01 May 1984

Disposition of enalapril and its diacid metabolite, enalaprilat, in a perfused rat liver preparation. Presence of a diffusional barrier for enalaprilat into hepatocytes is …
instance of (P31):
scholarly articleQ13442814

External links are
P953full work available at URLhttp://intl-dmd.aspetjournals.org/cgi/content/abstract/12/3/309
P698PubMed publication ID6145558

P2093author name stringK. S. Pang
W. F. Cherry
E. H. Ulm
J. A. Terrell
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectenalaprilQ422185
P304page(s)309-313
P577publication date1984-05-01
P1433published inDrug Metabolism and DispositionQ1261140
P1476titleDisposition of enalapril and its diacid metabolite, enalaprilat, in a perfused rat liver preparation. Presence of a diffusional barrier for enalaprilat into hepatocytes
P478volume12

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cites work (P2860)
Q68494333A physiological model for renal drug metabolism: enalapril esterolysis to enalaprilat in the isolated perfused rat kidney
Q39842309A review of metabolite kinetics
Q38462832An understanding of flow- and diffusion-limited vs. carrier-mediated hepatic transport: a simulation study
Q44296682Bile lipid secretion in isolated perfused rat liver. A model for metabolic studies
Q72304790Combined recirculation of the rat liver and kidney: studies with enalapril and enalaprilat
Q44495253Effect of a diffusional barrier to a metabolite across hepatocytes on its kinetics in "enzyme-distributed" models: a computer-aided simulation study
Q39501948Enalapril. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension and congestive heart failure
Q72304786Formed and preformed metabolite excretion clearances in liver, a metabolite formation organ: studies on enalapril and enalaprilat in the single-pass and recirculating perfused rat liver
Q36296199In vivo-formed versus preformed metabolite kinetics of trans-resveratrol-3-sulfate and trans-resveratrol-3-glucuronide
Q46450656Nipecotic acid: systemic availability and brain delivery after nasal administration of nipecotic acid and n-butyl nipecotate to rats
Q72746261Pharmacokinetics and bioinversion of ibuprofen enantiomers in humans
Q37820451Physiologically-based pharmacokinetic modeling for absorption, transport, metabolism and excretion.
Q46467130Preclinical pharmacokinetics and stability of isophosphoramide mustard
Q34125053Role of multidrug resistance-associated protein 4 in the basolateral efflux of hepatically derived enalaprilat.

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