Targeted impairment of thymidine kinase 2 expression in cells induces mitochondrial DNA depletion and reveals molecular mechanisms of compensation of mitochondrial respiratory activity.

scientific article published on 5 March 2011

Targeted impairment of thymidine kinase 2 expression in cells induces mitochondrial DNA depletion and reveals molecular mechanisms of compensation of mitochondrial respiratory activity. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BBRC.2011.03.018
P932PMC publication ID7586248
P698PubMed publication ID21382338
P5875ResearchGate publication ID50303501

P50authorJoan VillarroyaQ56516644
Anna MeseguerQ57204755
P2093author name stringMichio Hirano
Elena García-Arumí
Maya R Vilà
Beatriz Dorado
Mari-Carmen Lara
Marta Garrido
P2860cites workMPV17 encodes an inner mitochondrial membrane protein and is mutated in infantile hepatic mitochondrial DNA depletionQ24313262
Deficiency of the ADP-forming succinyl-CoA synthase activity is associated with encephalomyopathy and mitochondrial DNA depletionQ24530876
Deficiency of the alpha subunit of succinate-coenzyme A ligase causes fatal infantile lactic acidosis with mitochondrial DNA depletionQ24678341
The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNAQ28203048
Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathyQ28203066
Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletionQ28301052
Thymidine kinase 2 (H126N) knockin mice show the essential role of balanced deoxynucleotide pools for mitochondrial DNA maintenance.Q28504546
Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient miceQ28513054
Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in miceQ29619811
Mitochondrial expression of the human equilibrative nucleoside transporter 1 (hENT1) results in enhanced mitochondrial toxicity of antiviral drugs.Q34275557
Human mitochondrial DNA is packaged with TFAM.Q34908739
mtDNA depletion with variable tissue expression: a novel genetic abnormality in mitochondrial diseasesQ35196481
Origins of mitochondrial thymidine triphosphate: Dynamic relations to cytosolic poolsQ36348709
Modulation of the equilibrative nucleoside transporter by inhibitors of DNA synthesis.Q36679693
Thymidylate nucleotide supply for mitochondrial DNA synthesis in mouse L-cells. Effect of 5-fluorodeoxyuridine and methotrexate in thymidine kinase plus and thymidine kinase minus cellsQ39769361
Altered gene transcription profiles in fibroblasts harboring either TK2 or DGUOK mutations indicate compensatory mechanisms.Q39876288
Mitochondrial thymidine kinase and the enzymatic network regulating thymidine triphosphate pools in cultured human cellsQ40072616
p53R2-dependent ribonucleotide reduction provides deoxyribonucleotides in quiescent human fibroblasts in the absence of induced DNA damage.Q40148183
Identification of the mitochondrial targeting signal of the human equilibrative nucleoside transporter 1 (hENT1): implications for interspecies differences in mitochondrial toxicity of fialuridineQ40295834
Mitochondrial deoxyribonucleoside triphosphate pools in thymidine kinase 2 deficiencyQ40556977
An electron-transport system associated with the outer membrane of liver mitochondria. A biochemical and morphological studyQ41093578
POLG mutations associated with Alpers' syndrome and mitochondrial DNA depletionQ46178330
Selective muscle fiber loss and molecular compensation in mitochondrial myopathy due to TK2 deficiency.Q46894354
Early-onset encephalomyopathy associated with tissue-specific mitochondrial DNA depletion: a morphological, biochemical and molecular-genetic studyQ48070846
Infantile hepatocerebral syndromes associated with mutations in the mitochondrial DNA polymerase-gammaA.Q49085097
Recessive Twinkle mutations in early onset encephalopathy with mtDNA depletionQ50455384
Biochemical and molecular investigations in respiratory chain deficienciesQ72792351
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectmitochondrial DNAQ27075
P1104number of pages6
P304page(s)333-338
P577publication date2011-03-05
P1433published inBiochemical and Biophysical Research CommunicationsQ864228
P1476titleTargeted impairment of thymidine kinase 2 expression in cells induces mitochondrial DNA depletion and reveals molecular mechanisms of compensation of mitochondrial respiratory activity
P478volume407

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cites work (P2860)
Q36845872Digital PCR methods improve detection sensitivity and measurement precision of low abundance mtDNA deletions.
Q96303722Mitochondrial Toxicogenomics for Antiretroviral Management: HIV Post-exposure Prophylaxis in Uninfected Patients
Q39025697Mitochondrial purine and pyrimidine metabolism and beyond

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