Mitochondrial deoxyribonucleoside triphosphate pools in thymidine kinase 2 deficiency

scientific article published on October 24, 2003

Mitochondrial deoxyribonucleoside triphosphate pools in thymidine kinase 2 deficiency is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.BBRC.2003.09.104
P953full work available at URLhttps://api.elsevier.com/content/article/PII:S0006291X03019089?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S0006291X03019089?httpAccept=text/xml
P698PubMed publication ID14550298

P50authorAnn SaadaQ41879584
P2093author name stringOrly Elpeleg
Efrat Ben-Shalom
Hanna Mandel
Chaya Miller
Rivka Zyslin
P2860cites workThymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorderQ22008732
Mammalian deoxyribonucleoside kinasesQ28111474
Human mitochondrial 5'-deoxyribonucleotidase. Overproduction in cultured cells and functional aspectsQ28119093
The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNAQ28203048
Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathyQ28203066
Mitochondrial basis for immune deficiency. Evidence from purine nucleoside phosphorylase-deficient miceQ28590225
Inherited mitochondrial DNA depletionQ34195471
Site-specific somatic mitochondrial DNA point mutations in patients with thymidine phosphorylase deficiencyQ35095598
Effects of biological DNA precursor pool asymmetry upon accuracy of DNA replication in vitroQ40752812
Cell cycle-dependent metabolism of pyrimidine deoxynucleoside triphosphates in CEM cellsQ41103860
mtDNA depletion myopathy: elucidation of the tissue specificity in the mitochondrial thymidine kinase (TK2) deficiencyQ42441777
Depletion of the other genome-mitochondrial DNA depletion syndromes in humansQ44058609
Mitochondrial DNA depletion: mutations in thymidine kinase gene with myopathy and SMA.Q44187783
Kinetic properties of mutant human thymidine kinase 2 suggest a mechanism for mitochondrial DNA depletion myopathyQ44257239
Mutation analysis in 16 patients with mtDNA depletion.Q44375076
Reversion of mtDNA depletion in a patient with TK2 deficiencyQ44394599
Enzymatic assay for deoxyribonucleoside triphosphates using synthetic oligonucleotides as template primersQ69359556
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectbiophysicsQ7100
cell biologyQ7141
biochemistryQ7094
P304page(s)963-966
P577publication date2003-10-01
2003-10-24
P1433published inBiochemical and Biophysical Research CommunicationsQ864228
P1476titleMitochondrial deoxyribonucleoside triphosphate pools in thymidine kinase 2 deficiency
P478volume310

Reverse relations

cites work (P2860)
Q346524443'-Azido-3'-deoxythymidine (AZT) inhibits thymidine phosphorylation in isolated rat liver mitochondria: a possible mechanism of AZT hepatotoxicity
Q346959133'-Azido-3'-deoxythymidine (AZT) is a competitive inhibitor of thymidine phosphorylation in isolated rat heart and liver mitochondria
Q33783130A critical analysis of the combined usage of protein localization prediction methods: Increasing the number of independent data sets can reduce the accuracy of predicted mitochondrial localization
Q35535022A review comparing deoxyribonucleoside triphosphate (dNTP) concentrations in the mitochondrial and cytoplasmic compartments of normal and transformed cells
Q92223851Age-related metabolic changes limit efficacy of deoxynucleoside-based therapy in thymidine kinase 2-deficient mice
Q39876288Altered gene transcription profiles in fibroblasts harboring either TK2 or DGUOK mutations indicate compensatory mechanisms.
Q92429246Bioavailability and cytosolic kinases modulate response to deoxynucleoside therapy in TK2 deficiency
Q34131169Deoxypyrimidine monophosphate bypass therapy for thymidine kinase 2 deficiency.
Q35967198Deoxyribonucleoside kinases in mitochondrial DNA depletion
Q54538759Measurement of mitochondrial dNTP pools.
Q46413898Mitochondrial deoxyribonucleotide pools in deoxyguanosine kinase deficiency
Q36765849Mitochondrial diseases: a nosological update.
Q34399422Onset and organ specificity of Tk2 deficiency depends on Tk1 down-regulation and transcriptional compensation
Q45951063Origin of pyrimidine deoxyribonucleotide pools in perfused rat heart: implications for 3'-azido-3'-deoxythymidine-dependent cardiotoxicity.
Q34652429Phosphorylation of thymidine and AZT in heart mitochondria: elucidation of a novel mechanism of AZT cardiotoxicity
Q37155666Structure, physiological role, and specific inhibitors of human thymidine kinase 2 (TK2): present and future.
Q39580147Targeted impairment of thymidine kinase 2 expression in cells induces mitochondrial DNA depletion and reveals molecular mechanisms of compensation of mitochondrial respiratory activity.
Q41014443The Deoxynucleoside Triphosphate Triphosphohydrolase Activity of SAMHD1 Protein Contributes to the Mitochondrial DNA Depletion Associated with Genetic Deficiency of Deoxyguanosine Kinase
Q37054681Thymidine kinase and mtDNA depletion in human cardiomyopathy: epigenetic and translational evidence for energy starvation
Q46542423Transgenic expression of the deoxynucleotide carrier causes mitochondrial damage that is enhanced by NRTIs for AIDS.
Q46156686Unchanged thymidine triphosphate pools and thymidine metabolism in two lines of thymidine kinase 2-mutated fibroblasts