| scholarly article | Q13442814 |
| P50 | author | Estela Area-Gomez | Q96010187 |
| P2093 | author name string | Michio Hirano | |
| Beatriz Dorado | |||
| Hasan O. Akman | |||
| P2860 | cites work | Journal of Anatomy | Q2108124 |
| Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA | Q24299860 | ||
| Cloning of the cDNA and chromosome localization of the gene for human thymidine kinase 2 | Q24310289 | ||
| MPV17 encodes an inner mitochondrial membrane protein and is mutated in infantile hepatic mitochondrial DNA depletion | Q24313262 | ||
| MTERF3 is a negative regulator of mammalian mtDNA transcription | Q24323198 | ||
| Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators | Q24557011 | ||
| Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: a potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis | Q24561539 | ||
| Control of thymidine kinase mRNA during the cell cycle | Q24613622 | ||
| Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1 | Q28131760 | ||
| Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy | Q28203066 | ||
| Molecular insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes | Q28301628 | ||
| Thymidine kinase 2 (H126N) knockin mice show the essential role of balanced deoxynucleotide pools for mitochondrial DNA maintenance. | Q28504546 | ||
| mTERF2 regulates oxidative phosphorylation by modulating mtDNA transcription | Q28512464 | ||
| Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice | Q28513054 | ||
| Human thymidine kinase 2: molecular cloning and characterisation of the enzyme activity with antiviral and cytostatic nucleoside substrates | Q28623873 | ||
| Transcriptional paradigms in mammalian mitochondrial biogenesis and function | Q29619590 | ||
| Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice | Q29619811 | ||
| Cloning and characterization of full-length mouse thymidine kinase 2: the N-terminal sequence directs import of the precursor protein into mitochondria | Q30658219 | ||
| Nuclear respiratory factor 2 induces the expression of many but not all human proteins acting in mitochondrial DNA transcription and replication | Q33662210 | ||
| Nuclear control of respiratory chain expression by nuclear respiratory factors and PGC-1-related coactivator | Q33783615 | ||
| Oxidative stress and upregulation of mitochondrial biogenesis genes in mitochondrial DNA-depleted HeLa cells | Q33860258 | ||
| Regulation by degradation, a cellular defense against deoxyribonucleotide pool imbalances | Q34022804 | ||
| Cytokinetics of neonatal brain cell development in rats as studied by the 'complete 3H-thymidine labelling' method | Q34041444 | ||
| Selective assays for thymidine kinase 1 and 2 and deoxycytidine kinase and their activities in extracts from human cells and tissues. | Q34245096 | ||
| 5-Bromovinyl 2'-deoxyuridine phosphorylation by mitochondrial and cytosolic thymidine kinase (TK2 and TK1) and its use in selective measurement of TK2 activity in crude extracts | Q34792296 | ||
| Early-onset liver mtDNA depletion and late-onset proteinuric nephropathy in Mpv17 knockout mice | Q34837616 | ||
| Thymidine kinase 2 defects can cause multi-tissue mtDNA depletion syndrome | Q34838465 | ||
| Mitochondrial deoxynucleotide pool sizes in mouse liver and evidence for a transport mechanism for thymidine monophosphate | Q35214674 | ||
| Transcriptional regulatory circuits controlling mitochondrial biogenesis and function | Q35683727 | ||
| Mitochondrial signaling: the retrograde response | Q35739853 | ||
| Mitotic degradation of human thymidine kinase 1 is dependent on the anaphase-promoting complex/cyclosome-CDH1-mediated pathway | Q36222297 | ||
| Origins of mitochondrial thymidine triphosphate: Dynamic relations to cytosolic pools | Q36348709 | ||
| Mitochondrial retrograde signaling | Q36505532 | ||
| Clinical spectrum of mitochondrial DNA depletion due to mutations in the thymidine kinase 2 gene | Q36565545 | ||
| Mitochondrial transcription and its regulation in mammalian cells | Q36732857 | ||
| DNA replication and transcription in mammalian mitochondria | Q36780113 | ||
| Interactions between deoxyribonucleotide and DNA synthesis | Q39532113 | ||
| Quantitation of cellular deoxynucleoside triphosphates | Q39843396 | ||
| Altered gene transcription profiles in fibroblasts harboring either TK2 or DGUOK mutations indicate compensatory mechanisms. | Q39876288 | ||
| Loss of thymidine kinase 2 alters neuronal bioenergetics and leads to neurodegeneration. | Q39927495 | ||
| Mitochondrial thymidine kinase and the enzymatic network regulating thymidine triphosphate pools in cultured human cells | Q40072616 | ||
| p53R2-dependent ribonucleotide reduction provides deoxyribonucleotides in quiescent human fibroblasts in the absence of induced DNA damage. | Q40148183 | ||
| Mitochondrial deoxyribonucleoside triphosphate pools in thymidine kinase 2 deficiency | Q40556977 | ||
| Retrograde Ca2+ signaling in C2C12 skeletal myocytes in response to mitochondrial genetic and metabolic stress: a novel mode of inter-organelle crosstalk | Q40976490 | ||
| mtDNA depletion myopathy: elucidation of the tissue specificity in the mitochondrial thymidine kinase (TK2) deficiency | Q42441777 | ||
| Tissue specific distribution of pyrimidine deoxynucleoside salvage enzymes shed light on the mechanism of mitochondrial DNA depletion | Q43026525 | ||
| Hematopoiesis in the thymidine kinase 2 deficient mouse model of mitochondrial DNA depletion syndrome | Q43075015 | ||
| Hearing loss in a patient with the myopathic form of mitochondrial DNA depletion syndrome and a novel mutation in the TK2 gene | Q43084771 | ||
| Two novel mutations in thymidine kinase-2 cause early onset fatal encephalomyopathy and severe mtDNA depletion | Q43190746 | ||
| Mitochondrial DNA depletion: mutations in thymidine kinase gene with myopathy and SMA. | Q44187783 | ||
| Reversion of mtDNA depletion in a patient with TK2 deficiency | Q44394599 | ||
| Termination of transcription in human mitochondria: identification and purification of a DNA binding protein factor that promotes termination | Q45345563 | ||
| Metabolic interrelations within guanine deoxynucleotide pools for mitochondrial and nuclear DNA maintenance. | Q46640859 | ||
| Selective muscle fiber loss and molecular compensation in mitochondrial myopathy due to TK2 deficiency. | Q46894354 | ||
| Expression of deoxynucleoside kinases and 5'-nucleotidases in mouse tissues: implications for mitochondrial toxicity | Q48172801 | ||
| Changes of thymidine kinase in the developing rat brain | Q48797456 | ||
| Thymidine metabolism and deoxyribonucleic acid synthesis in the developing rat brain. | Q51143268 | ||
| Nuclear responses to depletion of mitochondrial DNA in human cells | Q71569113 | ||
| Cardiomyocyte DNA synthesis and binucleation during murine development | Q71839305 | ||
| Late-onset mitochondrial DNA depletion: DNA copy number, multiple deletions, and compensation | Q73892405 | ||
| Termination factor-mediated DNA loop between termination and initiation sites drives mitochondrial rRNA synthesis | Q82081316 | ||
| Bromovinyl-deoxyuridine: A selective substrate for mitochondrial thymidine kinase in cell extracts | Q83186238 | ||
| P4510 | describes a project that uses | ImageJ | Q1659584 |
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 155-164 | |
| P577 | publication date | 2010-10-11 | |
| P1433 | published in | Human Molecular Genetics | Q2720965 |
| P1476 | title | Onset and organ specificity of Tk2 deficiency depends on Tk1 down-regulation and transcriptional compensation | |
| P478 | volume | 20 |
| Q92618200 | A high expression of MTERF3 correlates with tumor progression and predicts poor outcomes in patients with brain glioma |
| Q92223851 | Age-related metabolic changes limit efficacy of deoxynucleoside-based therapy in thymidine kinase 2-deficient mice |
| Q94450758 | Basic biochemical characterization of cytosolic enzymes in thymidine nucleotide synthesis in adult rat tissues: implications for tissue specific mitochondrial DNA depletion and deoxynucleoside-based therapy for TK2-deficiency |
| Q92429246 | Bioavailability and cytosolic kinases modulate response to deoxynucleoside therapy in TK2 deficiency |
| Q47945459 | Deoxycytidine and Deoxythymidine Treatment for Thymidine Kinase 2 Deficiency. |
| Q34131169 | Deoxypyrimidine monophosphate bypass therapy for thymidine kinase 2 deficiency. |
| Q28476437 | Enzyme kinetics of the mitochondrial deoxyribonucleoside salvage pathway are not sufficient to support rapid mtDNA replication |
| Q34558619 | Gene expression deregulation in postnatal skeletal muscle of TK2 deficient mice reveals a lower pool of proliferating myogenic progenitor cells |
| Q50426370 | Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome. |
| Q54538759 | Measurement of mitochondrial dNTP pools. |
| Q37909459 | Mechanisms of mitochondrial diseases |
| Q36060187 | Metabolism of deoxypyrimidines and deoxypyrimidine antiviral analogs in isolated brain mitochondria |
| Q36642203 | Mitochondrial DNA copy number variation across human cancers |
| Q37961478 | Mitochondrial transcription: lessons from mouse models |
| Q39214553 | Synthesis of mitochondrial DNA precursors during myogenesis, an analysis in purified C2C12 myotubes. |
| Q39017134 | Targeting nuclear thymidylate biosynthesis |
| Q34626065 | Thymidine kinase 2 deficiency-induced mtDNA depletion in mouse liver leads to defect β-oxidation |
| Q37054681 | Thymidine kinase and mtDNA depletion in human cardiomyopathy: epigenetic and translational evidence for energy starvation |
| Q36534337 | Tissue-specific oxidative stress and loss of mitochondria in CoQ-deficient Pdss2 mutant mice. |
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