Regulation by degradation, a cellular defense against deoxyribonucleotide pool imbalances

scientific article

Regulation by degradation, a cellular defense against deoxyribonucleotide pool imbalances is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1016/J.MRGENTOX.2010.06.002
P698PubMed publication ID20561600

P2093author name stringVera Bianchi
Giovanna Pontarin
Paola Ferraro
Chiara Rampazzo
Peter Reichard
Elisa Franzolin
Miriam Frangini
Cristina Miazzi
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)2-10
P577publication date2010-06-16
P1433published inMutation ResearchQ6943732
P1476titleRegulation by degradation, a cellular defense against deoxyribonucleotide pool imbalances
P478volume703

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cites work (P2860)
Q36553774A continuous spectrophotometric enzyme-coupled assay for deoxynucleoside triphosphate triphosphohydrolases
Q48252877A defective dNTP pool hinders DNA replication in cell cycle-reactivated terminally differentiated muscle cells
Q41813473A mathematical model of human thymidine kinase 2 activity.
Q92223851Age-related metabolic changes limit efficacy of deoxynucleoside-based therapy in thymidine kinase 2-deficient mice
Q42218789Allosteric regulation of the human and mouse deoxyribonucleotide triphosphohydrolase sterile α-motif/histidine-aspartate domain-containing protein 1 (SAMHD1).
Q27316931Crystal structures of the novel cytosolic 5'-nucleotidase IIIB explain its preference for m7GMP
Q97643915Defects in mtDNA replication challenge nuclear genome stability through nucleotide depletion and provide a unifying mechanism for mouse progerias
Q41997479Deoxyribonucleotide metabolism in cycling and resting human fibroblasts with a missense mutation in p53R2, a subunit of ribonucleotide reductase
Q38572102Deoxyribonucleotide metabolism, mutagenesis and cancer
Q38220118Deoxyribonucleotides as genetic and metabolic regulators
Q47843426Fast and sensitive HPLC-MS/MS method for direct quantification of intracellular deoxyribonucleoside triphosphates from tissue and cells
Q33606917GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state
Q34558619Gene expression deregulation in postnatal skeletal muscle of TK2 deficient mice reveals a lower pool of proliferating myogenic progenitor cells
Q24605899How SAMHD1 changes our view of viral restriction
Q38011246Human HAD phosphatases: structure, mechanism, and roles in health and disease
Q90632452Identification of a novel heterozygous guanosine monophosphate reductase (GMPR) variant in a patient with a late-onset disorder of mitochondrial DNA maintenance
Q58086605Identification of inhibitors of the dNTP triphosphohydrolase SAMHD1 using a novel and direct high throughput assay
Q37149212Inhibition of DNA synthesis facilitates expansion of low-complexity repeats: is strand slippage stimulated by transient local depletion of specific dNTPs?
Q36690563Interferon block to HIV-1 transduction in macrophages despite SAMHD1 degradation and high deoxynucleoside triphosphates supply
Q28477625Limited dCTP availability accounts for mitochondrial DNA depletion in mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)
Q36170870Mammalian ribonucleotide reductase subunit p53R2 is required for mitochondrial DNA replication and DNA repair in quiescent cells
Q39632964Mechanism of the allosteric regulation of Streptococcus mutans 2'-deoxycytidylate deaminase.
Q27001150Mitochondrial DNA damage and its consequences for mitochondrial gene expression
Q36728526Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response
Q28081515Nucleotide salvage deficiencies, DNA damage and neurodegeneration
Q34399422Onset and organ specificity of Tk2 deficiency depends on Tk1 down-regulation and transcriptional compensation
Q42414226Out of S-phase: shift of subunits for ribonucleotide reduction
Q47547801Oxidation of dCTP contributes to antibiotic lethality in stationary-phase mycobacteria
Q57061841Pharmacogenetic variation influences sensory neuropathy occurrence in Southern Africans treated with stavudine-containing antiretroviral therapy
Q90231049Purine-Metabolising Enzymes and Apoptosis in Cancer
Q26785350Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications
Q37404941Relationships between human vitality and mitochondrial respiratory parameters, reactive oxygen species production and dNTP levels in peripheral blood mononuclear cells.
Q35758944Relative mRNA expression of prostate-derived E-twenty-six factor and E-twenty-six variant 4 transcription factors, and of uridine phosphorylase-1 and thymidine phosphorylase enzymes, in benign and malignant prostatic tissue
Q55056626Restricting HIV the SAMHD1 way: through nucleotide starvation.
Q38218536Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies
Q36812510Ribonucleotide reductase association with mammalian liver mitochondria
Q34401495Ribonucleotide reductase is not limiting for mitochondrial DNA copy number in mice
Q52431678SAMHD1 enhances immunoglobulin hypermutation by promoting transversion mutation.
Q34399058SAMHD1 prevents autoimmunity by maintaining genome stability
Q34058270SAMHD1 specifically affects the antiviral potency of thymidine analog HIV reverse transcriptase inhibitors
Q52723862SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity.
Q38728094Stably transfected adherent cancer cell models with decreased expression of 5'-nucleotidase cN-II.
Q34383850Structural basis of cellular dNTP regulation by SAMHD1.
Q44518086Substrate ambiguity among the nudix hydrolases: biologically significant, evolutionary remnant, or both?
Q34548496Substrates and Inhibitors of SAMHD1.
Q41014443The Deoxynucleoside Triphosphate Triphosphohydrolase Activity of SAMHD1 Protein Contributes to the Mitochondrial DNA Depletion Associated with Genetic Deficiency of Deoxyguanosine Kinase
Q47118199The Dynamic Interplay between HIV-1, SAMHD1, and the Innate Antiviral Response
Q28771774The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells
Q37143515The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells.
Q47284445The expression profile of sterile alpha motif and histidine-aspartate domain-containing protein 1 (SAMHD1) in feline tissues
Q30368734The first crystal structure of a dTTP-bound deoxycytidylate deaminase validates and details the allosteric-inhibitor binding site.
Q91808380The missing link: allostery and catalysis in the anti-viral protein SAMHD1
Q28570313Thymidine kinase 1 regulatory fine-tuning through tetramer formation
Q59349536Xanthine-based acyclic nucleoside phosphonates with potent antiviral activity against varicella-zoster virus and human cytomegalovirus
Q53695910dNTP metabolism links mechanical cues and YAP/TAZ to cell growth and oncogene-induced senescence.
Q34169187dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages.
Q41933397p21 Restricts HIV-1 in Monocyte-Derived Dendritic Cells through the Reduction of Deoxynucleoside Triphosphate Biosynthesis and Regulation of SAMHD1 Antiviral Activity
Q37240650p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway

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