| scholarly article | Q13442814 |
| review article | Q7318358 |
| P6179 | Dimensions Publication ID | 1031310264 |
| P356 | DOI | 10.1186/S12943-015-0446-6 |
| P932 | PMC publication ID | 4587406 |
| P698 | PubMed publication ID | 26416562 |
| P5875 | ResearchGate publication ID | 282333328 |
| P50 | author | Rebecca Kohnken | Q61197732 |
| Li Wu | Q42358492 | ||
| P2093 | author name string | Karthik M Kodigepalli | |
| P2860 | cites work | Hallmarks of Cancer: The Next Generation | Q22252312 |
| Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response | Q24338296 | ||
| Mechanism of allosteric activation of SAMHD1 by dGTP | Q24338757 | ||
| Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase | Q24339547 | ||
| SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx | Q24605940 | ||
| Core signaling pathways in human pancreatic cancers revealed by global genomic analyses | Q24606006 | ||
| A decade of exploring the cancer epigenome - biological and translational implications | Q24614467 | ||
| SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates | Q24624362 | ||
| Comprehensive molecular characterization of human colon and rectal cancer | Q24630415 | ||
| Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein | Q24635842 | ||
| An integrated genomic analysis of human glioblastoma multiforme | Q24648860 | ||
| HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase | Q27675416 | ||
| The consensus coding sequences of human breast and colorectal cancers | Q27861035 | ||
| 5-Fluorouracil: mechanisms of action and clinical strategies | Q28201937 | ||
| The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data | Q28266682 | ||
| Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions | Q29614216 | ||
| DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis | Q29614217 | ||
| Ribonucleotide reductases | Q29620027 | ||
| Intraclonal heterogeneity and distinct molecular mechanisms characterize the development of t(4;14) and t(11;14) myeloma. | Q53170046 | ||
| Nucleic acid metabolism and systemic autoimmunity revisited | Q82777953 | ||
| Cellular and Biochemical Mechanisms of the Retroviral Restriction Factor SAMHD1. | Q37571689 | ||
| Mechanisms of dNTP supply that play an essential role in maintaining genome integrity in eukaryotic cells | Q37793347 | ||
| The biology of HDAC in cancer: the nuclear and epigenetic components | Q37924191 | ||
| Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies | Q38218536 | ||
| MicroRNA-181 expression regulates specific post-transcriptional level of SAMHD1 expression in vitro | Q38958411 | ||
| Inhibition of Hepatitis B virus replication by SAMHD1. | Q38975576 | ||
| SAMHD1-dependent retroviral control and escape in mice. | Q39122691 | ||
| Phosphorylation of SAMHD1 by cyclin A2/CDK1 regulates its restriction activity toward HIV-1. | Q39163475 | ||
| Interactions between deoxyribonucleotide and DNA synthesis | Q39532113 | ||
| Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns | Q39564847 | ||
| Resistance to 9-beta-D-arabinofuranosyl-2-fluoroadenine due to reduced incorporation into DNA from competition by excess deoxyadenosine triphosphate: implications for different sensitivities to nucleoside analogues | Q40374312 | ||
| International Commission for Protection Against Environmental Mutagens and Carcinogens. Deoxyribonucleoside triphosphate levels: a critical factor in the maintenance of genetic stability | Q40391223 | ||
| p21 regulates the HIV-1 restriction factor SAMHD1. | Q42354536 | ||
| Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint | Q42738775 | ||
| Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase | Q29871440 | ||
| SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells. | Q30421200 | ||
| Identification of cellular proteins interacting with the retroviral restriction factor SAMHD1 | Q33602815 | ||
| Nucleotide metabolism, oncogene-induced senescence and cancer | Q33969333 | ||
| Regulation by degradation, a cellular defense against deoxyribonucleotide pool imbalances | Q34022804 | ||
| SAMHD1 specifically affects the antiviral potency of thymidine analog HIV reverse transcriptase inhibitors | Q34058270 | ||
| Nucleoside analogues and nucleobases in cancer treatment. | Q34141323 | ||
| A mutator phenotype in cancer. | Q34222899 | ||
| The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation | Q34340339 | ||
| Downregulation of SAMHD1 expression correlates with promoter DNA methylation in Sézary syndrome patients. | Q34359715 | ||
| Modulation of LINE-1 and Alu/SVA retrotransposition by Aicardi-Goutières syndrome-related SAMHD1. | Q34371066 | ||
| Reciprocal regulation of autophagy and dNTP pools in human cancer cells | Q34373116 | ||
| Structural basis of cellular dNTP regulation by SAMHD1. | Q34383850 | ||
| SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage. | Q34391609 | ||
| SAMHD1 prevents autoimmunity by maintaining genome stability | Q34399058 | ||
| SAMHD1 is down regulated in lung cancer by methylation and inhibits tumor cell proliferation | Q34450827 | ||
| Aicardi-Goutières syndrome | Q34555493 | ||
| Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells | Q34663141 | ||
| Cyclin L2 is a critical HIV dependency factor in macrophages that controls SAMHD1 abundance | Q34667185 | ||
| A large homozygous deletion in the SAMHD1 gene causes atypical Aicardi-Goutiéres syndrome associated with mtDNA deletions | Q34705253 | ||
| Evolving insights in the pathogenesis and therapy of cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome) | Q35022833 | ||
| A review comparing deoxyribonucleoside triphosphate (dNTP) concentrations in the mitochondrial and cytoplasmic compartments of normal and transformed cells | Q35535022 | ||
| Generation of mutator mutants during carcinogenesis | Q36344524 | ||
| Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events. | Q36446169 | ||
| SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons | Q36480173 | ||
| Evolution and impact of subclonal mutations in chronic lymphocytic leukemia | Q36619124 | ||
| Restriction of diverse retroviruses by SAMHD1. | Q36707281 | ||
| Promoter methylation regulates SAMHD1 gene expression in human CD4+ T cells | Q36725053 | ||
| Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response | Q36728526 | ||
| Recurrent R-spondin fusions in colon cancer | Q36949683 | ||
| Nucleotide deficiency promotes genomic instability in early stages of cancer development | Q37087191 | ||
| The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells. | Q37143515 | ||
| Nucleoside analogs: molecular mechanisms signaling cell death. | Q37310211 | ||
| SAMHD1 restricts herpes simplex virus 1 in macrophages by limiting DNA replication. | Q37336418 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | deoxyribonucleotide | Q28751 |
| neoplasm | Q1216998 | ||
| genome instability | Q2892636 | ||
| monomeric GTP-binding proteins | Q78190013 | ||
| P5008 | on focus list of Wikimedia project | ScienceSource | Q55439927 |
| P304 | page(s) | 176 | |
| P577 | publication date | 2015-09-29 | |
| P1433 | published in | Molecular Cancer | Q15724585 |
| P1476 | title | Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications | |
| P478 | volume | 14 |
| Q39113436 | A Critical Balance: dNTPs and the Maintenance of Genome Stability |
| Q50101944 | A Cyclin-binding Motif in Human SAMHD1 Is Required for Its HIV-1 Restriction, dNTPase Activity, Tetramer Formation, and Efficient Phosphorylation |
| Q38732874 | A Putative Cyclin-binding Motif in Human SAMHD1 Contributes to Protein Phosphorylation, Localization, and Stability |
| Q92034738 | Acetylation regulates ribonucleotide reductase activity and cancer cell growth |
| Q88396237 | Assessment of a panel of cellular biomarkers and the kinetics of their induction in comparing genotoxic modes of action in HepG2 cells |
| Q57455832 | Chromosomal instability causes sensitivity to protein folding stress and ATP depletion |
| Q93067058 | Clonal evolution of acute myeloid leukemia from diagnosis to relapse |
| Q90288506 | DHS (trans-4,4'-dihydroxystilbene) suppresses DNA replication and tumor growth by inhibiting RRM2 (ribonucleotide reductase regulatory subunit M2) |
| Q53688741 | Deoxyribonucleotide Triphosphate Metabolism in Cancer and Metabolic Disease. |
| Q47093634 | Differential response to exercise in claudin-low breast cancer |
| Q38727148 | Exogenous expression of SAMHD1 inhibits proliferation and induces apoptosis in cutaneous T-cell lymphoma-derived HuT78 cells. |
| Q36866147 | Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance |
| Q58086605 | Identification of inhibitors of the dNTP triphosphohydrolase SAMHD1 using a novel and direct high throughput assay |
| Q64059069 | Melanoma proteomics suggests functional differences related to mutational status |
| Q92005076 | Metabolic characterization of colorectal cancer cells harbouring different KRAS mutations in codon 12, 13, 61 and 146 using human SW48 isogenic cell lines |
| Q34547269 | Metabolism, Biochemical Actions, and Chemical Synthesis of Anticancer Nucleosides, Nucleotides, and Base Analogs |
| Q34545956 | MicroRNA-181 contributes to downregulation of SAMHD1 expression in CD4+ T-cells derived from Sèzary syndrome patients |
| Q101121278 | New strategies to treat AML: novel insights into AML survival pathways and combination therapies |
| Q38870074 | POLD1: Central mediator of DNA replication and repair, and implication in cancer and other pathologies |
| Q54977830 | Prognostic Value of RNASEH2A-, CDK1-, and CD151-Related Pathway Gene Profiling for Kidney Cancers. |
| Q90231049 | Purine-Metabolising Enzymes and Apoptosis in Cancer |
| Q54109628 | SAMHD1 Phosphorylation Coordinates the Anti-HIV-1 Response by Diverse Interferons and Tyrosine Kinase Inhibition. |
| Q40082412 | SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination. |
| Q58566372 | SAMHD1 Suppression of Antiviral Immune Responses |
| Q38770662 | SAMHD1 controls cell cycle status, apoptosis and HIV-1 infection in monocytic THP-1 cells |
| Q93359971 | SAMHD1 inhibits epithelial cell transformation in vitro and affects leukemia development in xenograft mice |
| Q34547626 | SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia. |
| Q57275043 | SAMHD1 modulates in vitro proliferation of acute myeloid leukemia-derived THP-1 cells through the PI3K-Akt-p27 axis |
| Q52723862 | SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity. |
| Q92751078 | Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming |
| Q41919532 | Targeting Nucleotide Biosynthesis: A Strategy for Improving the Oncolytic Potential of DNA Viruses |
| Q47118199 | The Dynamic Interplay between HIV-1, SAMHD1, and the Innate Antiviral Response |
| Q36243217 | The nature and nurture of cell heterogeneity: accounting for macrophage gene-environment interactions with single-cell RNA-Seq |
| Q90210434 | The role of dNTP metabolites in control of the embryonic cell cycle |
| Q64282716 | The roles of glucose metabolic reprogramming in chemo- and radio-resistance |
| Q57469903 | USP18 (UBP43) Abrogates p21-Mediated Inhibition of HIV-1 |
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