The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells

scientific journal article

The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1042/BJ20130894
P698PubMed publication ID24467396

P50authorAntonio E VidalQ46461888
Dolores Gonzalez-PacanowskaQ58331782
Cristina E RequenaQ59542729
Luis Miguel Ruiz-PérezQ59677934
P2093author name stringGuiomar Pérez-Moreno
P2860cites workThymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorderQ22008732
Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sitesQ24328865
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosineQ24614582
The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerasesQ24630867
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNAQ24632387
Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidationQ26823896
The crystal structure of Trypanosoma cruzi dUTPase reveals a novel dUTP/dUDP binding foldQ27642947
Crystal structure of RS21-C6, involved in nucleoside triphosphate pyrophosphohydrolysisQ27643893
Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathyQ28203066
Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletionQ28301052
Limited dCTP availability accounts for mitochondrial DNA depletion in mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)Q28477625
Mouse RS21-C6 is a mammalian 2'-deoxycytidine 5'-triphosphate pyrophosphohydrolase that prefers 5-iodocytosineQ28585369
Conformation and proton configuration of pyrimidine deoxynucleoside oxidation damage products in waterQ30597717
House cleaning, a part of good housekeepingQ31026672
Regulation by degradation, a cellular defense against deoxyribonucleotide pool imbalancesQ34022804
Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential "house-cleaning" functionsQ34399208
Mutagenic potentials of damaged nucleic acids produced by reactive oxygen/nitrogen species: approaches using synthetic oligonucleotides and nucleotides: survey and summaryQ35044983
Site-specific somatic mitochondrial DNA point mutations in patients with thymidine phosphorylase deficiencyQ35095598
Oxidative DNA damage and disease: induction, repair and significanceQ35876708
Triptolide directly inhibits dCTP pyrophosphatase.Q36415832
DNA precursor metabolism and genomic stabilityQ36525542
Molecular mechanisms of mitochondrial DNA depletion diseases caused by deficiencies in enzymes in purine and pyrimidine metabolismQ37207113
Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cellsQ42489935
Global DNA methylation: comparison of enzymatic- and non-enzymatic-based methodsQ42846115
Fishing in the (deoxyribonucleotide) poolQ43288107
Site-directed mutagenesis provides insights into the selective binding of trityl derivatives to Plasmodium falciparum dUTPaseQ43997028
Mutagenicity of 5-formylcytosine, an oxidation product of 5-methylcytosine, in DNA in mammalian cellsQ44163703
Quantitation of deoxyribonucleoside 5'-triphosphates by a sequential boronate and anion-exchange high-pressure liquid chromatographic procedureQ44490718
Partial depletion and multiple deletions of muscle mtDNA in familial MNGIE syndromeQ48370716
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectDCTP pyrophosphatase 1Q21132202
dTTP catabolic processQ22275390
P304page(s)171-180
P577publication date2014-04-01
P1433published inBiochemical JournalQ864221
P1476titleThe NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells
P478volume459

Reverse relations

cites work (P2860)
Q39113436A Critical Balance: dNTPs and the Maintenance of Genome Stability
Q64980090CRISPR/Cas9-Mediated Knock-Out of dUTPase in Mice Leads to Early Embryonic Lethality.
Q27720126Cell cycle regulation and novel structural features of thymidine kinase, an essential enzyme in Trypanosoma brucei
Q90441063Chemical proteomics reveals target selectivity of clinical Jak inhibitors in human primary cells
Q37708838DCTPP1 attenuates the sensitivity of human gastric cancer cells to 5-fluorouracil by up-regulating MDR1 expression epigenetically
Q92390701DCTPP1 prevents a mutator phenotype through the modulation of dCTP, dTTP and dUTP pools
Q38220118Deoxyribonucleotides as genetic and metabolic regulators
Q36588979Detection of uracil within DNA using a sensitive labeling method for in vitro and cellular applications.
Q36580244Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1
Q64273388Genome-scale CRISPR/Cas9 screen determines factors modulating sensitivity to ProTide NUC-1031
Q35818222Human dCTP pyrophosphatase 1 promotes breast cancer cell growth and stemness through the modulation on 5-methyl-dCTP metabolism and global hypomethylation
Q33631201Prepartal Energy Intake Alters Blood Polymorphonuclear Leukocyte Transcriptome During the Peripartal Period in Holstein Cows
Q38232763Preventive DNA repair by sanitizing the cellular (deoxy)nucleoside triphosphate pool
Q61818177Sex-Specific Gene Expression in the Mouse Nucleus Accumbens Before and After Cocaine Exposure
Q28547297Structural and Kinetic Characterization of Thymidine Kinase from Leishmania major
Q41919532Targeting Nucleotide Biosynthesis: A Strategy for Improving the Oncolytic Potential of DNA Viruses
Q38650970The druggability of intracellular nucleotide-degrading enzymes

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