CRISPR/Cas9-Mediated Knock-Out of dUTPase in Mice Leads to Early Embryonic Lethality.

scientific article published on 4 April 2019

CRISPR/Cas9-Mediated Knock-Out of dUTPase in Mice Leads to Early Embryonic Lethality. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/BIOM9040136
P932PMC publication ID6523736
P698PubMed publication ID30987342

P50authorGergely RónaQ55590432
Gergely TihanyiQ86359440
Elen GóczaQ90464788
László HiripiQ47129115
P2093author name stringBeáta G Vértessy
Orsolya Ivett Hoffmann
Zoltán Gál
Gergely Attila Rácz
Hajnalka Laura Pálinkás
P2860cites workCCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction ToolQ21131779
Keeping uracil out of DNA: physiological role, structure and catalytic mechanism of dUTPasesQ24646369
dUTPase: the frequently overlooked enzyme encoded by many retrovirusesQ26799724
Uracil-containing DNA in Drosophila: stability, stage-specific accumulation, and developmental involvementQ27333589
Active site of mycobacterial dUTPase: structural characteristics and a built-in sensorQ27650735
The Crystal Structure of the Leishmania major Deoxyuridine Triphosphate Nucleotidohydrolase in Complex with Nucleotide Analogues, dUMP, and DeoxyuridineQ27667393
On the catalytic mechanism of dimeric dUTPasesQ27685456
Human dUTP pyrophosphatase: uracil recognition by a beta hairpin and active sites formed by three separate subunitsQ27733410
dUTP pyrophosphatase is an essential enzyme in Saccharomyces cerevisiaeQ27933078
Cell cycle regulation of human DNA repair and chromatin remodeling genesQ28260595
Modulation of human dUTPase using small interfering RNAQ28300863
Crystal structure of the Mycobacterium tuberculosis dUTPase: insights into the catalytic mechanismQ28486334
The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cellsQ28771774
DNA targeting specificity of RNA-guided Cas9 nucleasesQ29615793
House cleaning, a part of good housekeepingQ31026672
Herpesviruses dUTPases: A New Family of Pathogen-Associated Molecular Pattern (PAMP) Proteins with Implications for Human DiseaseQ31152067
Potential steps in the evolution of a fused trimeric all-β dUTPase involve a catalytically competent fused dimeric intermediate.Q51662031
First-in-human, phase I dose-escalation study of single and multiple doses of a first-in-class enhancer of fluoropyrimidines, a dUTPase inhibitor (TAS-114) in healthy male volunteersQ87146227
TAS-114, a First-in-Class Dual dUTPase/DPD Inhibitor, Demonstrates Potential to Improve Therapeutic Efficacy of Fluoropyrimidine-Based ChemotherapyQ88633027
Maternal control of early mouse developmentQ33710885
Homologous recombination is stimulated by a decrease in dUTPase in Arabidopsis.Q33889340
Differential control of dNTP biosynthesis and genome integrity maintenance by the dUTPase superfamily enzymesQ33921147
The maternal-to-zygotic transition: a play in two actsQ34998975
Life without dUTPaseQ37438613
Standing the test of time: targeting thymidylate biosynthesis in cancer therapyQ38204673
Preventive DNA repair by sanitizing the cellular (deoxy)nucleoside triphosphate poolQ38232763
Abrogation of the CLK-2 checkpoint leads to tolerance to base-excision repair intermediates.Q38778670
MTH1 as a nucleotide pool sanitizing enzyme: Friend or foe?Q39004867
Cellular response to efficient dUTPase RNAi silencing in stable HeLa cell lines perturbs expression levels of genes involved in thymidylate metabolism.Q39502512
Lethality of a dut (deoxyuridine triphosphatase) mutation in Escherichia coliQ39952289
Small interfering RNA-mediated suppression of dUTPase sensitizes cancer cell lines to thymidylate synthase inhibitionQ40523518
Developmental regulation of dUTPase in Drosophila melanogasterQ40583083
Site-directed chemical modification of archaeal Thermococcus litoralis Sh1B DNA polymerase: Acquired ability to read through template-strand uracilsQ43163465
The monomeric dUTPase from Epstein-Barr virus mimics trimeric dUTPasesQ45423959
Kinetic properties and stereospecificity of the monomeric dUTPase from herpes simplex virus type 1.Q45751840
Inhibition of Dr-dut gene causes DNA damage in planarian.Q48099667
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P921main subjectCRISPRQ412563
Cas9Q16965677
CRISPR-Cas methodQ17310682
P577publication date2019-04-04
P1433published inBiomoleculesQ23929963
P1476titleCRISPR/Cas9-Mediated Knock-Out of dUTPase in Mice Leads to Early Embryonic Lethality
P478volume9

Reverse relations

Q92590156The Role of a Key Amino Acid Position in Species-Specific Proteinaceous dUTPase Inhibitioncites workP2860

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