Methylation of transcription factor binding sites in the Epstein-Barr virus latent cycle promoter Wp coincides with promoter down-regulation during virus-induced B-cell transformation

scientific article published on November 2000

Methylation of transcription factor binding sites in the Epstein-Barr virus latent cycle promoter Wp coincides with promoter down-regulation during virus-induced B-cell transformation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.74.22.10468-10479.2000
P932PMC publication ID110921
P698PubMed publication ID11044091
P5875ResearchGate publication ID12280586

P50authorAndrew I BellQ37376473
P2093author name stringA B Rickinson
J Desmond
R J Tierney
H E Kirby
J K Nagra
P2860cites workTranscriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complexQ24324026
A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strandsQ24562877
Methylated DNA and MeCP2 recruit histone deacetylase to repress transcriptionQ29547568
Methylation-induced repression--belts, braces, and chromatinQ29617487
Epstein-barr virus nuclear antigen 1 sequences in endemic and sporadic Burkitt's lymphoma reflect virus strains prevalent in different geographic areas.Q33640115
The Epstein-Barr virus major latent promoter Qp is constitutively active, hypomethylated, and methylation sensitiveQ33783746
Redefining the Epstein-Barr virus-encoded nuclear antigen EBNA-1 gene promoter and transcription initiation site in group I Burkitt lymphoma cell linesQ33784685
The Epstein-Barr virus promoter initiating B-cell transformation is activated by RFX proteins and the B-cell-specific activator protein BSAP/Pax5Q33787243
DNA sequence and expression of the B95-8 Epstein-Barr virus genome.Q34245077
Mutually exclusive use of viral promoters in Epstein-Barr virus latently infected lymphocytesQ34299744
The human J kappa recombination signal sequence binding protein (RBP-J kappa) targets the Epstein-Barr virus EBNA2 protein to its DNA responsive elements.Q34327455
Conservation and progressive methylation of Epstein-Barr viral DNA sequences in transformed cells.Q35237244
The Epstein-Barr virus nuclear antigen 2 transactivator is directed to response elements by the J kappa recombination signal binding proteinQ35648541
Transcription start sites downstream of the Epstein-Barr virus (EBV) Fp promoter in early-passage Burkitt lymphoma cells define a fourth promoter for expression of the EBV EBNA-1 proteinQ35854017
oriP is essential for EBNA gene promoter activity in Epstein-Barr virus-immortalized lymphoblastoid cell lines.Q35867579
Transcriptional activation of the Epstein-Barr virus latency C promoter after 5-azacytidine treatment: evidence that demethylation at a single CpG site is crucial.Q36555784
Host-cell-determined methylation of specific Epstein-Barr virus promoters regulates the choice between distinct viral latency programsQ36564877
Epstein-Barr virus latency in blood mononuclear cells: analysis of viral gene transcription during primary infection and in the carrier state.Q36637195
Methylation of discrete sites within the enhancer region regulates the activity of the Epstein-Barr virus BamHI W promoter in Burkitt lymphoma linesQ36655826
Variable expression of latent membrane protein in nasopharyngeal carcinoma can be related to methylation status of the Epstein-Barr virus BNLF-1 5'-flanking regionQ36682729
EBNA-2 transactivates a lymphoid-specific enhancer in the BamHI C promoter of Epstein-Barr virusQ36688330
Epstein-Barr virus latent gene expression in uncultured peripheral blood lymphocytesQ36698199
Host-cell-phenotype-dependent control of the BCR2/BWR1 promoter complex regulates the expression of Epstein-Barr virus nuclear antigens 2-6Q36808722
Epstein-Barr virus nuclear antigen 2 transactivates latent membrane protein LMP1.Q36810617
A promoter of Epstein-Barr virus that can function during latent infection can be transactivated by EBNA-1, a viral protein required for viral DNA replication during latent infection.Q36828303
5-Azacytidine up regulates the expression of Epstein-Barr virus nuclear antigen 2 (EBNA-2) through EBNA-6 and latent membrane protein in the Burkitt's lymphoma line raelQ36829470
Prolonged inhibitory effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine against replication of Epstein-Barr virusQ36913920
Monoclonal and polyclonal antibodies against Epstein-Barr virus nuclear antigen 5 (EBNA-5) detect multiple protein species in Burkitt's lymphoma and lymphoblastoid cell linesQ36920279
Significant potential secondary structures in the Epstein-Barr virus genomeQ37399426
Role for the Epstein-Barr virus nuclear antigen 2 in viral promoter switching during initial stages of infectionQ37504372
Restricted Epstein-Barr virus protein expression in Burkitt lymphoma is due to a different Epstein-Barr nuclear antigen 1 transcriptional initiation siteQ37552683
Cellular and viral DNA hypomethylation associated with induction of Epstein-Barr virus lytic cycleQ37557036
Exclusive expression of Epstein-Barr virus nuclear antigen 1 in Burkitt lymphoma arises from a third promoter, distinct from the promoters used in latently infected lymphocytesQ37557660
Promoter switching in Epstein-Barr virus during the initial stages of infection of B lymphocytesQ37707304
CpG methylation within the 5' regulatory region of the BRCA1 gene is tumor specific and includes a putative CREB binding siteQ38338770
CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activationQ38344762
Specific methylation patterns in two control regions of Epstein-Barr virus latency: the LMP-1-coding upstream regulatory region and an origin of DNA replication (oriP).Q39579096
Differential methylation of Epstein-Barr virus latency promoters facilitates viral persistence in healthy seropositive individuals.Q39596964
Regulation of EBNA gene transcription in lymphoblastoid cell lines: characterization of sequences downstream of BCR2 (Cp).Q39877574
Identification of the site of Epstein-Barr virus persistence in vivo as a resting B cellQ39880077
Mapping promoter regions that are hypersensitive to methylation-mediated inhibition of transcription: application of the methylation cassette assay to the Epstein-Barr virus major latency promoter.Q39880772
B-cell lines immortalized with an Epstein-Barr virus mutant lacking the Cp EBNA2 enhancer are biased toward utilization of the oriP-proximal EBNA gene promoter Wp1.Q40015317
Epstein-Barr virus nuclear antigen 2 activates transcription of the terminal protein geneQ40062679
Epstein-Barr virus nuclear antigen 2 induces expression of the virus-encoded latent membrane protein.Q40108807
Long-term T-cell-mediated immunity to epstein-barr virus in man. I. Complete regression of virus-induced transformation in cultures of seropositive donor leukocytesQ40189656
Binding sites in mammalian genes and viral gene regulatory regions recognized by methylated DNA-binding proteinQ40525481
Epstein-Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP-J kappa, the homologue of Drosophila Suppressor of Hairless.Q40793575
The activity of the Epstein-Barr virus BamHI W promoter in B cells is dependent on the binding of CREB/ATF factorsQ40892767
Characterisation of regulatory sequences at the Epstein-Barr virus BamHI W promoterQ40984027
Creation of genomic methylation patternsQ40986760
Methylation of the Epstein-Barr virus genome in normal lymphocytesQ41075320
CpG methylation of the major Epstein-Barr virus latency promoter in Burkitt's lymphoma and Hodgkin's diseaseQ41158549
Host cell phenotype-dependent methylation patterns of Epstein--Barr virus DNAQ41678227
Different Epstein-Barr virus-B cell interactions in phenotypically distinct clones of a Burkitt's lymphoma cell lineQ41729284
CpG methylation of viral DNA in EBV-associated tumoursQ41730871
The role of methylation in the phenotype-dependent modulation of Epstein-Barr nuclear antigen 2 and latent membrane protein genes in cells latently infected with Epstein-Barr virusQ42813897
Patterns of Epstein-Barr virus infection in non-neoplastic lymphoid tissueQ44068484
Expression of Epstein-Barr virus latent gene products in tumour cells of Hodgkin's diseaseQ44983123
Epstein-Barr virus (EBV) in endemic Burkitt's lymphoma: molecular analysis of primary tumor tissue.Q45758095
Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein J kappaQ45781476
Early events in Epstein-Barr virus infection of human B lymphocytesQ45855126
EBV persistence in memory B cells in vivo.Q52037383
Methylation-dependent and -independent DNA binding of nuclear factor EF-CQ67915836
A methylation-responsive MDBP/RFX site is in the first exon of the collagen alpha2(I) promoterQ73263524
Cytosine methylation of repeated sequences in eukaryotes: the role of DNA pairingQ77064368
P433issue22
P407language of work or nameEnglishQ1860
P921main subjectEpstein–Barr virusQ6900
P304page(s)10468-10479
P577publication date2000-11-01
P1433published inJournal of VirologyQ1251128
P1476titleMethylation of transcription factor binding sites in the Epstein-Barr virus latent cycle promoter Wp coincides with promoter down-regulation during virus-induced B-cell transformation
P478volume74

Reverse relations

cites work (P2860)
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