Heterogeneous Impact of ROCK2 on Carotid and Cerebrovascular Function

scientific article published on 18 July 2016

Heterogeneous Impact of ROCK2 on Carotid and Cerebrovascular Function is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1161/HYPERTENSIONAHA.116.07430
P932PMC publication ID4982851
P698PubMed publication ID27432870

P50authorTravice De SilvaQ64623399
Frank M FaraciQ86046795
P2093author name stringMary L Modrick
Dale A Kinzenbaw
Lindsey D Reinhardt
P2860cites workSelective ROCK2 inhibition in focal cerebral ischemiaQ24614558
ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cellsQ24646579
Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivityQ27642704
Rho Kinases in Health and Disease: From Basic Science to Translational ResearchQ28080702
Specificity and mechanism of action of some commonly used protein kinase inhibitorsQ28344791
Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphataseQ29615195
Cerebral small vessel disease: insights and opportunities from mouse models of collagen IV-related small vessel disease and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathyQ30574731
Activation of cerebellar climbing fibers increases cerebellar blood flow: role of glutamate receptors, nitric oxide, and cGMP.Q32115994
Penetrating arterioles are a bottleneck in the perfusion of neocortexQ33267690
Rho-associated kinase activity is a predictor of cardiovascular outcomes.Q33911873
Postischemic reperfusion causes smooth muscle calcium sensitization and vasoconstriction of parenchymal arteriolesQ34087786
Role of peroxisome proliferator-activated receptor-γ in vascular muscle in the cerebral circulationQ34315697
Vascular TRP channels: performing under pressure and going with the flowQ34428913
Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary PericytesQ34482679
Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanismQ34601386
Genetic interference with peroxisome proliferator-activated receptor γ in smooth muscle enhances myogenic tone in the cerebrovasculature via A Rho kinase-dependent mechanismQ34892807
Circulating endothelin-1 alters critical mechanisms regulating cerebral microcirculationQ34957350
Protecting against vascular disease in brainQ34979773
Potassium channelopathy-like defect underlies early-stage cerebrovascular dysfunction in a genetic model of small vessel disease.Q35128837
ROCK1 mediates leukocyte recruitment and neointima formation following vascular injuryQ36540884
Prevention of diabetes-induced arginase activation and vascular dysfunction by Rho kinase (ROCK) knockout.Q36787307
Microvascular Dysfunction and Cognitive Impairment.Q36839870
Age-related intimal stiffening enhances endothelial permeability and leukocyte transmigrationQ36957712
Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protectionQ37079168
Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient miceQ37092280
Effects of Early Post-Ischemic Reperfusion and tPA on Cerebrovascular Function and Nitrosative Stress in Female RatsQ37623559
Mechanisms of sporadic cerebral small vessel disease: insights from neuroimagingQ38100421
Regulation of large cerebral arteries and cerebral microvascular pressureQ38137923
Hypertension: renin-angiotensin-aldosterone system alterationsQ38376304
Acidosis dilates brain parenchymal arterioles by conversion of calcium waves to sparks to activate BK channels.Q42351857
Gln 63 of Rho is deamidated by Escherichia coli cytotoxic necrotizing factor-1.Q42799773
Role of inwardly rectifying K(+) channels in K(+)-induced cerebral vasodilatation in vivoQ43510277
Evidence that Rho-kinase activity contributes to cerebral vascular tone in vivo and is enhanced during chronic hypertension: comparison with protein kinase C.Q43590596
Involvement of Rho-kinase and the actin filament network in angiotensin II-induced contraction and extracellular signal-regulated kinase activity in intact rat mesenteric resistance arteriesQ43702962
Long-term inhibition of Rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: effect on endothelial NAD(P)H oxidase systemQ44590599
Impaired endothelium-dependent responses and enhanced influence of Rho-kinase in cerebral arterioles in type II diabetesQ45214949
Ca2+ sensitization via phosphorylation of myosin phosphatase targeting subunit at threonine-855 by Rho kinase contributes to the arterial myogenic responseQ46054871
Effects of fasudil in acute ischemic stroke: results of a prospective placebo-controlled double-blind trialQ46591653
Cerebral vascular effects of angiotensin II: new insights from genetic modelsQ46644984
Critical role for CuZn-superoxide dismutase in preventing angiotensin II-induced endothelial dysfunctionQ46745889
Pressor response induced by central angiotensin II is mediated by activation of Rho/Rho-kinase pathway via AT1 receptorsQ48315597
Rho kinase activity governs arteriolar myogenic depolarization.Q49157136
Rho-kinase phosphorylates eNOS at threonine 495 in endothelial cells.Q52681738
Effects of Rho kinase inhibition on cerebral artery myogenic tone and reactivity.Q53628625
Effect of nitric oxide and potassium channel agonists and inhibitors on basilar artery diameter.Q54167219
Effect of norepinephrine on rat basilar artery in vivoQ70555530
Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertensionQ73727736
Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPaseQ77195720
Cerebral vascular dysfunction in TallyHo mice: a new model of Type II diabetesQ79377957
Blood pressure and stroke: an overview of published reviewsQ79843018
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)809-817
P577publication date2016-07-18
P1433published inHypertensionQ5958695
P1476titleHeterogeneous Impact of ROCK2 on Carotid and Cerebrovascular Function
P478volume68

Reverse relations

cites work (P2860)
Q90685517Anti-arrhythmic properties of non-antiarrhythmic medications
Q95359203Augmented astrocyte microdomain Ca2+ dynamics and parenchymal arteriole tone in angiotensin II-infused hypertensive mice
Q39116577Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke
Q51741060Changes in Cerebral Arteries and Parenchymal Arterioles With Aging: Role of Rho Kinase 2 and Impact of Genetic Background.
Q54979587Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Is Essential for Preventing Endothelial Dysfunction With Aging.
Q47710820Genetic Interference With Endothelial PPAR-γ (Peroxisome Proliferator-Activated Receptor-γ) Augments Effects of Angiotensin II While Impairing Responses to Angiotensin 1-7.
Q92298812KD025 (SLx-2119) suppresses adipogenesis at intermediate stage in human adipose-derived stem cells
Q39444002Rho-associated protein kinases as therapeutic targets for both vascular and parenchymal pathologies in Alzheimer's disease.
Q33693655Selective inhibition of brain endothelial Rho-kinase-2 provides optimal protection of an in vitro blood-brain barrier from tissue-type plasminogen activator and plasmin.
Q90267047Spreading depolarizations trigger caveolin-1-dependent endothelial transcytosis

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