Genetic Interference With Endothelial PPAR-γ (Peroxisome Proliferator-Activated Receptor-γ) Augments Effects of Angiotensin II While Impairing Responses to Angiotensin 1-7.

scientific article published on 3 July 2017

Genetic Interference With Endothelial PPAR-γ (Peroxisome Proliferator-Activated Receptor-γ) Augments Effects of Angiotensin II While Impairing Responses to Angiotensin 1-7. is …
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scholarly articleQ13442814

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P356DOI10.1161/HYPERTENSIONAHA.117.09358
P932PMC publication ID5552422
P698PubMed publication ID28674038

P50authorCurt D. SigmundQ40187956
Travice De SilvaQ64623399
Frank M FaraciQ86046795
P2093author name stringChunyan Hu
Mary L Modrick
Dale A Kinzenbaw
P2860cites workDominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertensionQ22011018
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Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysisQ34604937
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Genetic interference with peroxisome proliferator-activated receptor γ in smooth muscle enhances myogenic tone in the cerebrovasculature via A Rho kinase-dependent mechanismQ34892807
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Emerging translational approaches to target STAT3 signalling and its impact on vascular diseaseQ35580177
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Cullin-3 regulates vascular smooth muscle function and arterial blood pressure via PPARγ and RhoA/Rho-kinase.Q36328405
Targeting Rho and Rho-kinase in the treatment of cardiovascular diseaseQ36352966
Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension.Q36509300
Interference with PPARγ in endothelium accelerates angiotensin II-induced endothelial dysfunctionQ36510633
Small-molecule inhibitors of signal transducer and activator of transcription 3 protect against angiotensin II-induced vascular dysfunction and hypertensionQ36660171
Interference with PPARgamma signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling.Q36692337
Endothelial PPAR-γ provides vascular protection from IL-1β-induced oxidative stressQ36699263
Role of chemokine RANTES in the regulation of perivascular inflammation, T-cell accumulation, and vascular dysfunction in hypertension.Q36812077
Dominant negative PPARγ promotes atherosclerosis, vascular dysfunction, and hypertension through distinct effects in endothelium and vascular muscleQ36837948
Endothelium-specific interference with peroxisome proliferator activated receptor gamma causes cerebral vascular dysfunction in response to a high-fat diet.Q36972995
Context-dependent effects of SOCS3 in angiotensin II-induced vascular dysfunction and hypertension in mice: mechanisms and role of bone marrow-derived cellsQ37139653
Carotid intimal medial thickness predicts cognitive decline among adults without clinical vascular diseaseQ37366566
Cullin-3 mutation causes arterial stiffness and hypertension through a vascular smooth muscle mechanismQ37417507
Does peroxisome proliferator-activated receptor-gamma (PPAR gamma) protect from hypertension directly through effects in the vasculature?Q37686890
Angiotensin-(1-7).Q38198985
Endothelial NADPH oxidases: which NOX to target in vascular disease?Q38234422
Heterogeneous Impact of ROCK2 on Carotid and Cerebrovascular FunctionQ39586548
NF-kappaB regulates phagocytic NADPH oxidase by inducing the expression of gp91phoxQ40331102
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Peroxisome proliferator-activated receptor-γ mutations responsible for lipodystrophy with severe hypertension activate the cellular renin-angiotensin systemQ44434235
Critical role for CuZn-superoxide dismutase in preventing angiotensin II-induced endothelial dysfunctionQ46745889
IL-6 deficiency protects against angiotensin II induced endothelial dysfunction and hypertrophyQ46930205
Gender affects renal vasoconstrictor response to Ang I and Ang II.Q50910668
Characterization of a new selective antagonist for angiotensin-(1-7), D-pro7-angiotensin-(1-7).Q51839155
Genetic Variation in PPARG Encoding Peroxisome Proliferator-Activated Receptor γ Associated With Carotid AtherosclerosisQ58771200
Longitudinal studies of estrous cyclicity in aging C57BL/6J mice: II. Cessation of cyclicity and the duration of persistent vaginal cornificationQ70798129
Investigation into the sources of superoxide in human blood vessels: angiotensin II increases superoxide production in human internal mammary arteriesQ73762643
Angiotensin-(1-7) causes endothelium-dependent relaxation in canine middle cerebral arteryQ74071611
Angiotensin-(1-7) modulates angiotensin II-induced vasoconstriction in human mammary arteryQ85737219
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)559-565
P577publication date2017-07-03
P1433published inHypertensionQ5958695
P1476titleGenetic Interference With Endothelial PPAR-γ (Peroxisome Proliferator-Activated Receptor-γ) Augments Effects of Angiotensin II While Impairing Responses to Angiotensin 1-7
P478volume70

Reverse relations

cites work (P2860)
Q90747615Contributions of Aging to Cerebral Small Vessel Disease
Q54979587Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Is Essential for Preventing Endothelial Dysfunction With Aging.
Q57787242Interference With Endothelial PPAR (Peroxisome Proliferator-Activated Receptor)-γ Causes Accelerated Cerebral Vascular Dysfunction in Response to Endogenous Renin-Angiotensin System Activation
Q47793724PPARγ and retinol binding protein 7 form a regulatory hub promoting antioxidant properties of the endothelium.
Q92928281The Nuclear Export and Ubiquitin-Proteasome-Dependent Degradation of PPARγ Induced By Angiotensin II

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