Mapping the FEN1 interaction domain with hTERT.

scientific article published on 21 February 2011

Mapping the FEN1 interaction domain with hTERT. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BBRC.2011.02.087
P932PMC publication ID3070821
P698PubMed publication ID21345332
P5875ResearchGate publication ID49942730

P2093author name stringWeihang Chai
Shilpa Sampathi
P2860cites workWRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication forkQ24301121
PML-IV functions as a negative regulator of telomerase by interacting with TERTQ24309336
A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesisQ24323178
The characterization of a mammalian DNA structure-specific endonucleaseQ24336672
Cell cycle-regulated trafficking of human telomerase to telomeresQ24540240
Lagging Strand DNA Synthesis at the Eukaryotic Replication Fork Involves Binding and Stimulation of FEN-1 by Proliferating Cell Nuclear AntigenQ27931829
Human Ku70/80 associates physically with telomerase through interaction with hTERTQ28115815
Flap endonuclease 1: a central component of DNA metabolismQ28266199
Proliferation failure and gamma radiation sensitivity of Fen1 null mutant mice at the blastocyst stageQ28509911
Enzymes and reactions at the eukaryotic DNA replication forkQ28610363
Telomeres shorten during ageing of human fibroblastsQ29547357
Regulation of telomerase by telomeric proteinsQ29616133
Cell cycle-dependent and DNA damage-inducible nuclear localization of FEN-1 nuclease is consistent with its dual functions in DNA replication and repairQ31505231
Studies of the molecular mechanisms in the regulation of telomerase activityQ33792301
The function of DNA polymerase alpha at telomeric G tails is important for telomere homeostasisQ33961700
Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progressionQ34098053
Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forksQ34166526
Interactions between telomerase and primase physically link the telomere and chromosome replication machineryQ34284600
Functional regulation of FEN1 nuclease and its link to cancerQ34559690
Replication proteins influence the maintenance of telomere length and telomerase protein stabilityQ34930176
Telomeres and cancer: a tale with many endingsQ35062454
Disruption of the FEN-1/PCNA interaction results in DNA replication defects, pulmonary hypoplasia, pancytopenia, and newborn lethality in miceQ35856777
Specific DNA replication mutations affect telomere length in Saccharomyces cerevisiaeQ36561802
Flap endonuclease 1 contributes to telomere stabilityQ36632697
Coordinate regulation of G- and C strand length during new telomere synthesisQ36942197
Human flap endonuclease I is in complex with telomerase and is required for telomerase-mediated telomere maintenanceQ37081922
Comprehensive mapping of the C-terminus of flap endonuclease-1 reveals distinct interaction sites for five proteins that represent different DNA replication and repair pathwaysQ37188352
Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cellsQ37305023
Partial functional deficiency of E160D flap endonuclease-1 mutant in vitro and in vivo is due to defective cleavage of DNA substratesQ38330972
Molecular steps of G-overhang generation at human telomeres and its function in chromosome end protectionQ39678675
Processing of branched DNA intermediates by a complex of human FEN-1 and PCNA.Q39716441
Fen-1 facilitates homologous recombination by removing divergent sequences at DNA break endsQ42043478
FEN1 ensures telomere stability by facilitating replication fork re-initiationQ42043800
Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT.Q42046068
Concerted action of exonuclease and Gap-dependent endonuclease activities of FEN-1 contributes to the resolution of triplet repeat sequences (CTG)n- and (GAA)n-derived secondary structures formed during maturation of Okazaki fragmentsQ46188277
Fen1 mutations result in autoimmunity, chronic inflammation and cancersQ46593630
TCAB1: driving telomerase to Cajal bodies.Q51737868
Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinaseQ64388536
Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta.Q64988940
CDC17: an essential gene that prevents telomere elongation in yeastQ69899501
In eukaryotic flap endonuclease 1, the C terminus is essential for substrate bindingQ73203986
Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunitQ77388144
The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeresQ79365400
[Flap endonuclease-1 and its role in the processes of DNA metabolism in eucaryotic cells]Q81782289
Telomere repeat binding factor 2 interacts with base excision repair proteins and stimulates DNA synthesis by DNA polymerase betaQ82193024
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)34-38
P577publication date2011-02-21
P1433published inBiochemical and Biophysical Research CommunicationsQ864228
P1476titleMapping the FEN1 interaction domain with hTERT.
P478volume407

Reverse relations

Q59132715SUMO-1 modification of FEN1 facilitates its interaction with Rad9-Rad1-Hus1 to counteract DNA replication stresscites workP2860

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