αO-Conotoxin GeXIVA disulfide bond isomers exhibit differential sensitivity for various nicotinic acetylcholine receptors but retain potency and selectivity for the human α9α10 subtype.

scientific article published on 14 April 2017

αO-Conotoxin GeXIVA disulfide bond isomers exhibit differential sensitivity for various nicotinic acetylcholine receptors but retain potency and selectivity for the human α9α10 subtype. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.NEUROPHARM.2017.04.015
P932PMC publication ID6029978
P698PubMed publication ID28416445

P50authorXiaopeng ZhuQ85545349
Dongting ZhangsunQ89834415
David CraikQ37375333
Quentin KaasQ37379889
P2093author name stringJ Michael McIntosh
Sulan Luo
Yong Wu
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Anti-hypersensitive effect of intramuscular administration of αO-conotoxin GeXIVA[1,2] and GeXIVA[1,4] in rats of neuropathic painQ39177181
A novel mechanism of inhibition of high-voltage activated calcium channels by α-conotoxins contributes to relief of nerve injury-induced neuropathic painQ39278993
Nicotine-induced human breast cancer cell proliferation attenuated by garcinol through down-regulation of the nicotinic receptor and cyclin D3 proteins.Q39727744
Conotoxin αD-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptorsQ40513209
Analgesic α-conotoxins Vc1.1 and RgIA inhibit N-type calcium channels in sensory neurons of α9 nicotinic receptor knockout miceQ43109150
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Analgesic alpha-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation.Q44676738
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Alpha-conotoxin Vc1.1 alleviates neuropathic pain and accelerates functional recovery of injured neuronesQ46718997
The T-superfamily of conotoxinsQ47920089
Nicotinic acetylcholine receptor-based blockade: applications of molecular targets for cancer therapy.Q52717994
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Are 9 10 Nicotinic Acetylcholine Receptors a Pain Target for -Conotoxins?Q60695375
One, four or 100 genera? A new classification of the cone snailsQ22043539
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Molecular mechanism for analgesia involving specific antagonism of alpha9alpha10 nicotinic acetylcholine receptorsQ24673308
Conotoxin Interactions with α9α10-nAChRs: Is the α9α10-Nicotinic Acetylcholine Receptor an Important Therapeutic Target for Pain Management?Q26783037
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A new level of conotoxin diversity, a non-native disulfide bond connectivity in alpha-conotoxin AuIB reduces structural definition but increases biological activityQ27639764
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Structure determination of the three disulfide bond isomers of alpha-conotoxin GI: a model for the role of disulfide bonds in structural stabilityQ27756877
Comparative protein modelling by satisfaction of spatial restraintsQ27860866
A novel alpha-conotoxin, PeIA, cloned from Conus pergrandis, discriminates between rat alpha9alpha10 and alpha7 nicotinic cholinergic receptorsQ33218073
Alpha-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of alpha3beta4 nicotinic acetylcholine receptors.Q33991060
Mechanisms of conotoxin inhibition of N-type (Ca(v)2.2) calcium channelsQ34326135
α9-nicotinic acetylcholine receptors contribute to the maintenance of chronic mechanical hyperalgesia, but not thermal or mechanical allodyniaQ34333395
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A novel inhibitor of α9α10 nicotinic acetylcholine receptors from Conus vexillum delineates a new conotoxin superfamily.Q34575566
Molecular interaction of α-conotoxin RgIA with the rat α9α10 nicotinic acetylcholine receptorQ35531867
Optimized deep-targeted proteotranscriptomic profiling reveals unexplored Conus toxin diversity and novel cysteine frameworks.Q35684927
Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist.Q35910100
New associations of the genetic polymorphisms in nicotinic receptor genes with the risk of lung cancerQ35925991
γ-Aminobutyric acid type B (GABAB) receptor expression is needed for inhibition of N-type (Cav2.2) calcium channels by analgesic α-conotoxinsQ36078883
Molecular basis for the differential sensitivity of rat and human α9α10 nAChRs to α-conotoxin RgIA.Q36208114
Alpha9 nicotinic acetylcholine receptors and the treatment of painQ37336577
Scanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha9alpha10 nicotinic acetylcholine receptorQ37339057
P304page(s)243-252
P577publication date2017-04-14
P1433published inNeuropharmacologyQ15332439
P1476titleαO-Conotoxin GeXIVA disulfide bond isomers exhibit differential sensitivity for various nicotinic acetylcholine receptors but retain potency and selectivity for the human α9α10 subtype
P478volume127

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cites work (P2860)
Q64949046Cervical Cancer Correlates with the Differential Expression of Nicotinic Acetylcholine Receptors and Reveals Therapeutic Targets.
Q92812567Differential Expression of Nicotine Acetylcholine Receptors Associates with Human Breast Cancer and Mediates Antitumor Activity of αO-Conotoxin GeXIVA
Q57456470Heterogeneous-Backbone Foldamer Mimics of a Computationally Designed, Disulfide-Rich Miniprotein
Q33833386Identification of a Novel O-Conotoxin Reveals an Unusual and Potent Inhibitor of the Human α9α10 Nicotinic Acetylcholine Receptor
Q47739924Nicotinic acetylcholine receptors in neuropathic and inflammatory pain.
Q60950252Orthosteric and/or Allosteric Binding of α-Conotoxins to Nicotinic Acetylcholine Receptors and Their Models
Q64090147d-Amino Acid Substitution of α-Conotoxin RgIA Identifies its Critical Residues and Improves the Enzymatic Stability

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