Nicotinic acetylcholine receptors in neuropathic and inflammatory pain.

scientific article published on 14 October 2017

Nicotinic acetylcholine receptors in neuropathic and inflammatory pain. is …
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scholarly articleQ13442814

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P356DOI10.1002/1873-3468.12884
P932PMC publication ID5899685
P698PubMed publication ID29030971

P50authorArik J HoneQ88416433
P2093author name stringJ Michael McIntosh
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Surfactant inhibits ATP-induced release of interleukin-1β via nicotinic acetylcholine receptorsQ47917345
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The α9α10 nicotinic receptor antagonist α-conotoxin RgIA prevents neuropathic pain induced by oxaliplatin treatmentQ48056690
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Heterogeneity of nicotinic cholinergic receptors in rat superior cervical and nodose GangliaQ80044490
alpha7 Nicotinic acetylcholine receptor stimulation inhibits lipopolysaccharide-induced interleukin-18 and -12 production in monocytesQ80230278
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Functional α7β2 nicotinic acetylcholine receptors expressed in hippocampal interneurons exhibit high sensitivity to pathological level of amyloid β peptidesQ34526528
Tonic inhibitory role of alpha4beta2 subtype of nicotinic acetylcholine receptors on nociceptive transmission in the spinal cord in miceQ34539248
Sazetidine-A, a novel ligand that desensitizes alpha4beta2 nicotinic acetylcholine receptors without activating themQ34549732
Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypesQ34636910
An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivoQ34648974
Sazetidine-A is a potent and selective agonist at native and recombinant alpha 4 beta 2 nicotinic acetylcholine receptorsQ34764699
α7-cholinergic receptor mediates vagal induction of splenic norepinephrineQ34872582
The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptorQ35034364
Short- and long-term enhancement of excitatory transmission in the spinal cord dorsal horn by nicotinic acetylcholine receptors.Q35144346
The interface between cholinergic pathways and the immune system and its relevance to arthritisQ35228289
The novel small molecule α9α10 nicotinic acetylcholine receptor antagonist ZZ-204G is analgesicQ35547518
Two novel α7 nicotinic acetylcholine receptor ligands: in vitro properties and their efficacy in collagen-induced arthritis in miceQ35548484
Investigation of the molecular mechanism of the α7 nicotinic acetylcholine receptor positive allosteric modulator PNU-120596 provides evidence for two distinct desensitized statesQ35586093
An Accessory Agonist Binding Site Promotes Activation of α4β2* Nicotinic Acetylcholine ReceptorsQ35662305
Nicotinic acetylcholine receptors in dorsal root ganglion neurons include the α6β4* subtype.Q35790283
Alpha7 nicotinic acetylcholine receptors modulate motivation to self-administer nicotine: implications for smoking and schizophreniaQ35837691
Pharmacological characterization of native α7 nicotinic ACh receptors and their contribution to depolarization-elicited exocytosis in human chromaffin cells.Q35853230
Novel small molecule α9α10 nicotinic receptor antagonist prevents and reverses chemotherapy-evoked neuropathic pain in ratsQ35853738
Population analyses of efficacy and safety of ABT-594 in subjects with diabetic peripheral neuropathic painQ35888354
Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist.Q35910100
Nicotinic Acetylcholine Receptors Modulate Bone Marrow-Derived Pro-Inflammatory Monocyte Production and SurvivalQ35939425
Function of human α3β4α5 nicotinic acetylcholine receptors is reduced by the α5(D398N) variantQ36126982
α-Conotoxins Identify the α3β4* Subtype as the Predominant Nicotinic Acetylcholine Receptor Expressed in Human Adrenal Chromaffin CellsQ36186102
Molecular basis for the differential sensitivity of rat and human α9α10 nAChRs to α-conotoxin RgIA.Q36208114
The vagus nerve and the nicotinic anti-inflammatory pathwayQ36214006
A Novel α2/α4 Subtype-selective Positive Allosteric Modulator of Nicotinic Acetylcholine Receptors Acting from the C-tail of an α SubunitQ36323450
Pharmacological stimulation of the cholinergic antiinflammatory pathwayQ36370255
Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammationQ36403437
Effects of α7 positive allosteric modulators in murine inflammatory and chronic neuropathic pain modelsQ36463363
The antinociceptive effects of nicotinic receptors α7-positive allosteric modulators in murine acute and tonic pain modelsQ36497623
α4β2 nicotinic acetylcholine receptors on dopaminergic neurons mediate nicotine reward and anxiety reliefQ36517174
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Differential modulation of EAE by α9*- and β2*-nicotinic acetylcholine receptorsQ36681341
In vivo pharmacological interactions between a type II positive allosteric modulator of α7 nicotinic ACh receptors and nicotinic agonists in a murine tonic pain modelQ36929434
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Pentameric concatenated (alpha4)(2)(beta2)(3) and (alpha4)(3)(beta2)(2) nicotinic acetylcholine receptors: subunit arrangement determines functional expressionQ37230743
The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptorsQ37246699
The selective alpha7 agonist GTS-21 attenuates cytokine production in human whole blood and human monocytes activated by ligands for TLR2, TLR3, TLR4, TLR9, and RAGE.Q37254561
Oral choline supplementation for postoperative painQ37345030
Novel ω-conotoxins from C. catus reverse signs of mouse inflammatory pain after systemic administration.Q37369881
The unique α4+/-α4 agonist binding site in (α4)3(β2)2 subtype nicotinic acetylcholine receptors permits differential agonist desensitization pharmacology versus the (α4)2(β2)3 subtypeQ37405338
The activity of GAT107, an allosteric activator and positive modulator of α7 nicotinic acetylcholine receptors (nAChR), is regulated by aromatic amino acids that span the subunit interfaceQ37583624
Expeditious synthesis, enantiomeric resolution, and enantiomer functional characterization of (4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide (4BP-TQS): an allosteric agonist-positive allosteric modulator of α7 nicotiQ37600251
Attenuation of Collagen-Induced Arthritis in rat by nicotinic alpha7 receptor partial agonist GTS-21.Q37639837
The therapeutic promise of positive allosteric modulation of nicotinic receptorsQ37695734
Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic painQ37695948
Alpha7 nicotinic receptors as novel therapeutic targets for inflammation-based diseasesQ37800819
Synthetic α-conotoxin mutants as probes for studying nicotinic acetylcholine receptors and in the development of novel drug leadsQ37954299
P2X receptor antagonists for pain management: examination of binding and physicochemical propertiesQ37956570
P2X receptors as drug targetsQ38068620
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectneuropathic painQ2798704
P304page(s)1045-1062
P577publication date2017-10-27
P1433published inFEBS LettersQ1388051
P1476titleNicotinic acetylcholine receptors in neuropathic and inflammatory pain
P478volume592