Efflux-pump-derived multiple drug resistance to ethambutol monotherapy in Mycobacterium tuberculosis and the pharmacokinetics and pharmacodynamics of ethambutol

scientific article published on April 2010

Efflux-pump-derived multiple drug resistance to ethambutol monotherapy in Mycobacterium tuberculosis and the pharmacokinetics and pharmacodynamics of ethambutol is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1086/651377
P932PMC publication ID2838947
P698PubMed publication ID20210628
P5875ResearchGate publication ID41824020

P50authorTawanda GumboQ40336008
Shashikant SrivastavaQ56381433
Daniel Richard LeffQ114413127
Carleton M ShermanQ117260814
Claudia MeekQ117260815
Sandirai MusukaQ117260819
P2860cites workPharmacokinetics of ethambutol under fasting conditions, with food, and with antacidsQ24550662
Probability distribution of drug-resistant mutants in unselected populations of Mycobacterium tuberculosisQ24624866
A balancing act: efflux/influx in mycobacterial drug resistanceQ24644870
Ancestral antibiotic resistance in Mycobacterium tuberculosisQ28486382
Mycobacterium tuberculosis isolate with a distinct genomic identity overexpresses a tap-like efflux pumpQ28486832
The Mycobacterium tuberculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutolQ28487116
Phenotypic and molecular characterization of Mycobacterium tuberculosis isolates resistant to both isoniazid and ethambutolQ33836636
Effects of AIDS and gender on steady-state plasma and intrapulmonary ethambutol concentrationsQ33983182
DnaE2 polymerase contributes to in vivo survival and the emergence of drug resistance in Mycobacterium tuberculosisQ34191816
Mutations in putative mutator genes of Mycobacterium tuberculosis strains of the W-Beijing familyQ34502921
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Moxifloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against Mycobacterium tuberculosis: evaluation of in vitro and pharmacodynamic indices that best predict in vivo efficacyQ35636012
First linezolid-resistant clinical isolates of Mycobacterium tuberculosisQ35758951
Multidrug-resistant Mycobacterium tuberculosis, Bangui, Central African RepublicQ35817507
Early bactericidal activity of antituberculosis agentsQ35917156
Isoniazid pharmacokinetics-pharmacodynamics in an aerosol infection model of tuberculosisQ36669451
Pharmacokinetics-pharmacodynamics of pyrazinamide in a novel in vitro model of tuberculosis for sterilizing effect: a paradigm for faster assessment of new antituberculosis drugsQ37274688
Multicenter evaluation of ethambutol susceptibility testing of mycobacterium tuberculosis by agar proportion and radiometric methodsQ39695137
Kinetics of oral ethambutol in the normal subjectQ41328113
Identification of mutations related to streptomycin resistance in clinical isolates of Mycobacterium tuberculosis and possible involvement of efflux mechanismQ41336509
Genetic variability and adaptation to stress.Q41620371
Pharmacodynamic evidence that ciprofloxacin failure against tuberculosis is not due to poor microbial kill but to rapid emergence of resistanceQ41876123
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The early bactericidal activity of drugs in patients with pulmonary tuberculosisQ42257164
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The Rapid Development of Fluoroquinolone Resistance inM. tuberculosisQ44653435
Selection of a moxifloxacin dose that suppresses drug resistance in Mycobacterium tuberculosis, by use of an in vitro pharmacodynamic infection model and mathematical modelingQ44662037
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Characterization of tetracycline resistance mediated by the efflux pump Tap from Mycobacterium fortuitumQ46864661
Role of mutator alleles in adaptive evolution.Q54564129
Isoniazid’s Bactericidal Activity Ceases because of the Emergence of Resistance, Not Depletion ofMycobacterium tuberculosisin the Log Phase of GrowthQ58033536
Disposition kinetics of ethambutol in manQ71368279
Studies of the early bactericidal activity of new drugs for tuberculosis: a help or a hindrance to antituberculosis drug development?Q74388171
How drug resistance emerges as a result of poor compliance during short course chemotherapy for tuberculosisQ74485447
Pyrazinamide (aldinamide) in the treatment of pulmonary tuberculosisQ76088832
Simultaneous ethambutol & isoniazid resistance in clinical isolates of Mycobacterium tuberculosisQ83019792
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectMycobacterium tuberculosisQ130971
pharmacokineticsQ323936
ethambutolQ412318
drug resistanceQ12147416
multiple drug resistanceQ643839
pharmacodynamicsQ725307
P304page(s)1225-1231
P577publication date2010-04-01
P1433published inJournal of Infectious DiseasesQ4051141
P1476titleEfflux-pump-derived multiple drug resistance to ethambutol monotherapy in Mycobacterium tuberculosis and the pharmacokinetics and pharmacodynamics of ethambutol
P478volume201

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