Hydrogen peroxide induces Beclin 1-independent autophagic cell death by suppressing the mTOR pathway via promoting the ubiquitination and degradation of Rheb in GSH-depleted RAW 264.7 cells

scientific article published on 10 November 2010

Hydrogen peroxide induces Beclin 1-independent autophagic cell death by suppressing the mTOR pathway via promoting the ubiquitination and degradation of Rheb in GSH-depleted RAW 264.7 cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3109/10715762.2010.535530
P698PubMed publication ID21067284

P50authorSeong-Beom LeeQ60310510
P2093author name stringSeong Keun Kim
Eunhye Oh
Seong-Whan Jeong
Yu Jeong Byun
Gue Tae Chae
Gimoon Seo
P2860cites workGuidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotesQ23757358
Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4Q24670840
Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell deathQ24676936
The responses of Ht22 cells to oxidative stress induced by buthionine sulfoximine (BSO)Q24793293
Hydrogen peroxide induces autophagic cell death in C6 glioma cells via BNIP3-mediated suppression of the mTOR pathwayQ28565482
Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagyQ28576035
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxiaQ28586744
Mitochondria, oxidative stress and cell deathQ29618996
Intracellular water motion decreases in apoptotic macrophages after caspase activation.Q30662352
Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinaseQ33796255
TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activityQ34598209
Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with RhebQ34700113
Regulation of apoptosis by ubiquitinationQ35129703
Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viabilityQ35916071
The rate of cellular hydrogen peroxide removal shows dependency on GSH: mathematical insight into in vivo H2O2 and GPx concentrationsQ36498664
Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagyQ37211352
Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systemsQ37664227
Depletion of glutathione by buthionine sulfoxine is cytotoxic for human neuroblastoma cell lines via apoptosisQ39483800
Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cellsQ39849848
Induction of autophagy by proteasome inhibitor is associated with proliferative arrest in colon cancer cells.Q39959646
Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cellsQ39990852
Mechanisms of BSO (L-buthionine-S,R-sulfoximine)-induced cytotoxic effects in neuroblastomaQ40054597
Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cellsQ40071790
The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor functionQ40250486
Proteasome inhibition induces both pro- and anti-cell death pathways in prostate cancer cellsQ40329502
A novel hydrogen peroxide-induced phosphorylation and ubiquitination pathway leading to RNA polymerase II proteolysisQ40609421
Hydrogen peroxide stimulates ubiquitin-conjugating activity and expression of genes for specific E2 and E3 proteins in skeletal muscle myotubesQ40644205
Effect of glutathione-modulating compounds on hydrogen-peroxide-induced cytotoxicity in human glioblastoma and glioma cell linesQ41135848
Growth arrest and autophagy are required for salivary gland cell degradation in DrosophilaQ41913649
Wortmannin inhibits carcinogen-stimulated phosphorylation of ethanolamine and cholineQ42830562
MG132 as a proteasome inhibitor induces cell growth inhibition and cell death in A549 lung cancer cells via influencing reactive oxygen species and GSH levelQ43201212
Hydrogen peroxide-induced apoptosis in pc12 cells and the protective effect of puerarinQ44671702
A novel function of poly(ADP-ribose) polymerase-1 in modulation of autophagy and necrosis under oxidative stress.Q46272227
Palmitate induced mitochondrial deoxyribonucleic acid damage and apoptosis in l6 rat skeletal muscle cellsQ53595198
Atg5: more than an autophagy factor.Q55042516
P433issue4
P921main subjectautophagyQ288322
cell deathQ2383867
protein ubiquitinationQ3547638
P304page(s)389-399
P577publication date2010-11-10
P1433published inFree Radical ResearchQ5500025
P1476titleHydrogen peroxide induces Beclin 1-independent autophagic cell death by suppressing the mTOR pathway via promoting the ubiquitination and degradation of Rheb in GSH-depleted RAW 264.7 cells
P478volume45

Reverse relations

cites work (P2860)
Q33878859A critical role of autophagy in antileukemia/lymphoma effects of APO866, an inhibitor of NAD biosynthesis
Q34873021Adiponectin Modulates Oxidative Stress-Induced Autophagy in Cardiomyocytes
Q38005691Alternative Macroautophagic Pathways
Q92282830Autophagy is Activated In Vivo during Trimethyltin-Induced Apoptotic Neurodegeneration: A Study in the Rat Hippocampus
Q39177430Autophagy protein p62/SQSTM1 is involved in HAMLET-induced cell death by modulating apotosis in U87MG cells
Q38099399Autophagy: Mechanisms, regulation, and its role in tumorigenesis
Q36506082Beclin 1 is required for starvation-enhanced, but not rapamycin-enhanced, LC3-associated phagocytosis of Burkholderia pseudomallei in RAW 264.7 cells
Q35914153Beclin-1 expression is retained in high-grade serous ovarian cancer yet is not essential for autophagy induction in vitro
Q28504511CCCP-Induced LC3 lipidation depends on Atg9 whereas FIP200/Atg13 and Beclin 1/Atg14 are dispensable
Q36039323Conessine Interferes with Oxidative Stress-Induced C2C12 Myoblast Cell Death through Inhibition of Autophagic Flux
Q91297685Control of mTOR signaling by ubiquitin
Q35871496Divergent roles of BECN1 in LC3 lipidation and autophagosomal function
Q44258998Ginsenoside Rb1 Enhances Atherosclerotic Plaque Stability by Improving Autophagy and Lipid Metabolism in Macrophage Foam Cells
Q35626616Globular Adiponectin Causes Tolerance to LPS-Induced TNF-α Expression via Autophagy Induction in RAW 264.7 Macrophages: Involvement of SIRT1/FoxO3A Axis
Q46750019Glutathione Depletion Induces Spermatogonial Cell Autophagy
Q92919218Green tea polyphenols protect PC12 cells against H2O2-induced damages by upregulating lncRNA MALAT1
Q28547509Impacts of autophagy-inducing ingredient of areca nut on tumor cells
Q37312661Impairment of Atg5-dependent autophagic flux promotes paraquat- and MPP⁺-induced apoptosis but not rotenone or 6-hydroxydopamine toxicity
Q37561244Influence of miR-155 on Cell Apoptosis in Rats with Ischemic Stroke: Role of the Ras Homolog Enriched in Brain (Rheb)/mTOR Pathway.
Q36581683Loss of a membrane trafficking protein αSNAP induces non-canonical autophagy in human epithelia
Q35018081MicroRNA-155 promotes autophagy to eliminate intracellular mycobacteria by targeting Rheb
Q35852420Palmitate induces cisternal ER expansion via the activation of XBP-1/CCTα-mediated phospholipid accumulation in RAW 264.7 cells
Q58134358Proteasome subunit beta type 1 interacts directly with Rheb and regulates the cell cycle in Cashmere goat fetal fibroblasts
Q91896679Protective Role of mTOR in Liver Ischemia/Reperfusion Injury: Involvement of Inflammation and Autophagy
Q38028304Reactive oxygen species regulation of autophagy in cancer: Implications for cancer treatment
Q34051183Recent progress in the study of the Rheb family GTPases.
Q38680160Roles of autophagy and metabolism in pancreatic cancer cell adaptation to environmental challenges
Q39360966Saturated hydrogen saline ameliorates lipopolysaccharide-induced acute lung injury by reducing excessive autophagy
Q99711523Serine Supports IL-1β Production in Macrophages Through mTOR Signaling
Q37412484TMEM166/EVA1A interacts with ATG16L1 and induces autophagosome formation and cell death
Q36733186The thiazole derivative CPTH6 impairs autophagy
Q47633679Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes.
Q91690576Unraveling the Potential Role of Glutathione in Multiple Forms of Cell Death in Cancer Therapy

Search more.