Nivolumab Monotherapy for First-Line Treatment of Advanced Non-Small-Cell Lung Cancer

scientific article published on 27 June 2016

Nivolumab Monotherapy for First-Line Treatment of Advanced Non-Small-Cell Lung Cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1200/JCO.2016.66.9929
P932PMC publication ID5569692
P698PubMed publication ID27354485

P50authorScott GettingerQ66809423
Hossein BorghaeiQ91136109
P2093author name stringFrances A Shepherd
Scott Antonia
David E Gerber
Yun Shen
Rosalyn A Juergens
Neal Ready
Matthew D Hellmann
Scott A Laurie
Jonathan W Goldman
Naiyer A Rizvi
Laura Q Chow
Julie Brahmer
Christopher T Harbison
Faith E Nathan
P2860cites workAdvanced EGFR mutation-positive non-small-cell lung cancer: case report, literature review, and treatment recommendationsQ27021203
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trialQ27851712
Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations.Q27852408
First-line crizotinib versus chemotherapy in ALK-positive lung cancerQ27853101
The blockade of immune checkpoints in cancer immunotherapyQ27860852
New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)Q28131668
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancerQ28278736
Comparison of four chemotherapy regimens for advanced non-small-cell lung cancerQ29615476
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancerQ29615679
Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlatesQ29620051
Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancerQ29620301
Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumabQ29620596
Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung CancerQ29620902
Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung CancerQ29620913
Pooled Analysis of Long-Term Survival Data From Phase II and Phase III Trials of Ipilimumab in Unresectable or Metastatic MelanomaQ30890582
Phase III randomized trial comparing three platinum-based doublets in advanced non-small-cell lung cancer.Q33345025
In vitro characterization of the anti-PD-1 antibody nivolumab, BMS-936558, and in vivo toxicology in non-human primatesQ34421845
Meta-analysis of first-line therapies in advanced non-small-cell lung cancer harboring EGFR-activating mutationsQ34449385
Overall Survival and Long-Term Safety of Nivolumab (Anti-Programmed Death 1 Antibody, BMS-936558, ONO-4538) in Patients With Previously Treated Advanced Non-Small-Cell Lung CancerQ36352827
The next generation of epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of lung cancerQ38292875
Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trialQ38364028
Efficacy and Safety of Nivolumab in Patients With BRAF V600 Mutant and BRAF Wild-Type Advanced Melanoma: A Pooled Analysis of 4 Clinical TrialsQ40729813
Exomics and immunogenics: Bridging mutational load and immune checkpoints efficacyQ41983246
Randomized phase III trial of paclitaxel plus carboplatin versus vinorelbine plus cisplatin in the treatment of patients with advanced non--small-cell lung cancer: a Southwest Oncology Group trialQ43658480
PointBreak: a randomized phase III study of pemetrexed plus carboplatin and bevacizumab followed by maintenance pemetrexed and bevacizumab versus paclitaxel plus carboplatin and bevacizumab followed by maintenance bevacizumab in patients with stageQ86564392
P433issue25
P407language of work or nameEnglishQ1860
P921main subjectlung cancerQ47912
P304page(s)2980-2987
P577publication date2016-06-27
P1433published inJournal of Clinical OncologyQ400292
P1476titleNivolumab Monotherapy for First-Line Treatment of Advanced Non-Small-Cell Lung Cancer
P478volume34

Reverse relations

cites work (P2860)
Q47637581A CD200R-CD28 fusion protein appropriates an inhibitory signal to enhance T-cell function and therapy of murine leukemia.
Q91830069A Molecular Epidemiological Analysis Of Programmed Cell Death Ligand-1 (PD-L1) Protein Expression, Mutations And Survival In Non-Small Cell Lung Cancer
Q90541288A consensus on immunotherapy from the 2017 Chinese Lung Cancer Summit expert panel
Q37552085A meta-analysis of efficacy and safety of antibodies targeting PD-1/PD-L1 in treatment of advanced nonsmall cell lung cancer
Q48191483Afatinib treatment of a squamous lung cancer after tumor progression of nivolumab.
Q90326662An observational study of concomitant immunotherapies and denosumab in patients with advanced melanoma or lung cancer
Q37584395Are immune checkpoint blockade monoclonal antibodies active against CNS metastases from NSCLC?-current evidence and future perspectives
Q38765001Beyond platinum treatment for NSCLC: what does the future hold?
Q94526308Biomarkers of immune checkpoint inhibitor efficacy in cancer
Q37741143Blocking the PD-1/PD-L1 pathway in glioma: a potential new treatment strategy
Q38840383Breaking the crosstalk of the cellular tumorigenic network: Hypothesis for addressing resistances to targeted therapies in advanced NSCLC.
Q56889030Cancer Immunotherapy in Diffuse Large B-Cell Lymphoma
Q89910962Cancer Treatment Response to Checkpoint Inhibitors Is Associated with Cytomegalovirus Infection
Q93013655Cancer immunotherapy experience in the Integral Oncology Centre "Diana Laura Riojas de Colosio", Médica Sur Hospital
Q30275719Carboplatin and pemetrexed with or without pembrolizumab for advanced, non-squamous non-small-cell lung cancer: a randomised, phase 2 cohort of the open-label KEYNOTE-021 study.
Q47711273Cell death-based treatment of lung adenocarcinoma
Q50231313Challenges and Opportunities in Adapting Clinical Trial Design for Immunotherapies
Q41722598Characterization of nivolumab-associated skin reactions in patients with metastatic non-small cell lung cancer
Q47133911Classifying Non-Small Cell Lung Cancer by Status of Programmed Cell Death Ligand 1 and Tumor-Infiltrating Lymphocytes on Tumor Cells
Q94552708Combination of pembrolizumab and 125I attenuates the aggressiveness of non-small cell lung cancer
Q99582797Compare the efficacy and safety of programmed cell death-1 (PD-1) and programmed cell death ligand-1 (PD-L1) inhibitors for advanced non-small cell lung cancer: a Bayesian analysis
Q47727627Comparison of the toxicity profile of PD-1 versus PD-L1 inhibitors in non-small cell lung cancer: A systematic analysis of the literature
Q53740080Composite biomarkers defined by multiparametric immunofluorescence analysis identify ALK-positive adenocarcinoma as a potential target for immunotherapy.
Q91599315Comprehensive analysis of potential immunotherapy genomic biomarkers in 1000 Chinese patients with cancer
Q90194707Conceptual Development of Immunotherapeutic Approaches to Gastrointestinal Cancer
Q58614434Concurrent versus non-concurrent immune checkpoint inhibition with stereotactic radiosurgery for metastatic brain disease: a systematic review and meta-analysis
Q92557086Correlation analysis of mRNA expression and prognosis of hOGG1 gene polymorphism in patients with non-small cell lung cancer
Q28076294Cross-talk between microbiota and immune fitness to steer and control response to anti PD-1/PDL-1 treatment
Q33645595Current state of immunotherapy for non-small cell lung cancer
Q52690105Defining the Most Appropriate Primary End Point in Phase 2 Trials of Immune Checkpoint Inhibitors for Advanced Solid Cancers: A Systematic Review and Meta-analysis.
Q58107449Developing combination strategies using PD-1 checkpoint inhibitors to treat cancer
Q88698989Diminished but not dead: chemotherapy for the treatment of NSCLC
Q55375458Do immune checkpoint inhibitors need new studies methodology?
Q47688850Efficacy and safety of retreatment with nivolumab in metastatic melanoma patients previously treated with nivolumab
Q98164819Efficacy of PD-1/PD-L1 blockade monotherapy in clinical trials
Q57034228Efficacy of anti-PD-1/PD-L1 antibodies after discontinuation due to adverse events in non-small cell lung cancer patients (HANSHIN 0316)
Q39441719Endocrine toxicity of immune checkpoint inhibitors: essential crosstalk between endocrinologists and oncologists.
Q50129978Evaluation of PD-L1 expression on vortex-isolated circulating tumor cells in metastatic lung cancer.
Q47131539Evaluation of rare but severe immune related adverse effects in PD-1 and PD-L1 inhibitors in non-small cell lung cancer: a meta-analysis
Q47259728Excellent response to chemotherapy post immunotherapy
Q49240447Expression and Comparison of Cbl-b in Lung Squamous Cell Carcinoma and Adenocarcinoma
Q47111652Expression of PD-1/PD-L1 and PD-L2 in peripheral T-cells from non-small cell lung cancer patients
Q61814958F-FDG and C-4DST PET/CT for evaluating response to platinum-based doublet chemotherapy in advanced non-small cell lung cancer: a prospective study
Q55256789Favorable outcome of patients with lung adenocarcinoma harboring POLE mutations and expressing high PD-L1.
Q39388286First-Line Nivolumab in Stage IV or Recurrent Non-Small-Cell Lung Cancer.
Q28073759Focus on Nivolumab in NSCLC
Q64971959Future Options of Molecular-Targeted Therapy in Small Cell Lung Cancer.
Q60104303Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors
Q92433697Granuloma-forming interstitial pneumonia induced by nivolumab: a possible immune-related adverse event of the lung
Q89767107Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas
Q49512731Identification of candidate responders for anti-PD-L1/PD-1 immunotherapy, Rova-T therapy, or EZH2 inhibitory therapy in small-cell lung cancer
Q90334361Immune Checkpoints as Promising Targets for the Treatment of Idiopathic Pulmonary Fibrosis?
Q33645590Immune checkpoint blockade for hematologic malignancies: a review
Q91812593Immune checkpoint inhibitor treatment in patients with oncogene- addicted non-small cell lung cancer (NSCLC): summary of a multidisciplinary round-table discussion
Q47563451Immune checkpoint inhibitors in advanced non-small cell lung cancer
Q92890675Immune profiling reveals the diverse nature of the immune response in NSCLC and reveals signaling pathways that may influence the anti-tumor immune response
Q37589557Immune-Checkpoint Inhibitors in the Era of Precision Medicine: What Radiologists Should Know
Q47101155Immune-Related Adverse Events Associated with Anti-PD-1/PD-L1 Treatment for Malignancies: A Meta-Analysis
Q60936723Immune-checkpoint inhibitor plus chemotherapy versus conventional chemotherapy for first-line treatment in advanced non-small cell lung carcinoma: a systematic review and meta-analysis
Q64967034Immune-related adverse events associated with programmed cell death protein-1 and programmed cell death ligand 1 inhibitors for non-small cell lung cancer: a PRISMA systematic review and meta-analysis.
Q48131613Immune-related intestinal pseudo-obstruction associated with nivolumab treatment in a lung cancer patient.
Q38772744Immunogenomics: using genomics to personalize cancer immunotherapy.
Q38703148Immunotherapeutic Approaches to Biliary Cancer
Q38687631Immunotherapeutic strategies in non-small-cell lung cancer: the present and the future
Q55503616Immunotherapy combination strategies (non-chemotherapy) in non-small cell lung cancer.
Q58699431Immunotherapy in Advanced Non-small Cell Lung Cancer Patients: Ushering Chemotherapy Through the Checkpoint Inhibitors?
Q55312983Immunotherapy in the Asiatic population: any differences from Caucasian population?
Q52624361Immunotherapy in treatment naïve advanced non-small cell lung cancer
Q38819349Immunotherapy of non-small cell lung cancer: report from an international experts panel meeting of the Italian association of thoracic oncology
Q55438062Impact of smoking on efficacy of PD-1/PD-L1 inhibitors in non-small cell lung cancer patients: a meta-analysis.
Q47705923Incidence of Endocrine Dysfunction Following the Use of Different Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-analysis.
Q55438940Incidence of immune checkpoint inhibitor-related colitis in solid tumor patients: A systematic review and meta-analysis.
Q90960156Interobserver Reproducibility of PD-L1 Biomarker in Non-small Cell Lung Cancer: A Multi-Institutional Study by 27 Pathologists
Q61799197L265P mutation and loss are early mutational events in primary central nervous system diffuse large B-cell lymphomas
Q39160974LAG3 (CD223) as a cancer immunotherapy target
Q38670099Limitations and opportunities for immune checkpoint inhibitors in pediatric malignancies
Q64963588Liquid biopsy for lung cancer immunotherapy.
Q60044246Local mutational diversity drives intratumoral immune heterogeneity in non-small cell lung cancer
Q49413036Locally advanced non-small cell lung cancer treatment: another step forward
Q88318229Lung cancer: First-line immunotherapy in lung cancer - taking the first step
Q90660460Lymphocyte-activation gene 3 (LAG3): The next immune checkpoint receptor
Q91906493M2 macrophage infiltration into tumor islets leads to poor prognosis in non-small-cell lung cancer
Q92586096Making cold malignant pleural effusions hot: driving novel immunotherapies
Q39458112Molecular imaging in drug development: Update and challenges for radiolabeled antibodies and nanotechnology.
Q49391681Multifunctional nanoparticles for cancer immunotherapy: A groundbreaking approach for reprogramming malfunctioned tumor environment
Q39007500New systemic strategies for overcoming resistance to targeted therapies in non-small cell lung cancer.
Q41508440Nivolumab in Combination With Platinum-Based Doublet Chemotherapy for First-Line Treatment of Advanced Non-Small-Cell Lung Cancer
Q39118471Nivolumab plus ipilimumab as first-line treatment for advanced non-small-cell lung cancer (CheckMate 012): results of an open-label, phase 1, multicohort study.
Q64939605Nivolumab plus ipilimumab combination therapy for the first-line treatment NSCLC: evidence to date.
Q40289794Nivolumab treatment for oesophageal squamous-cell carcinoma: an open-label, multicentre, phase 2 trial
Q38755931PD-1 and PD-L1 antibodies in cancer: current status and future directions
Q39033713PD-1 checkpoint blockade alone or combined PD-1 and CTLA-4 blockade as immunotherapy for lung cancer?
Q47120629PD-1/PD-L1 Blockade: Have We Found the Key to Unleash the Antitumor Immune Response?
Q47422615PD-L1 Testing in Guiding Patient Selection for PD-1/PD-L1 Inhibitor Therapy in Lung Cancer
Q36363579PD-L1 expression as a predictive biomarker in advanced non-small-cell lung cancer: updated survival data
Q38774259PD-L1 testing, fit for routine evaluation? From a pathologist's point of view
Q90030532Patterns of response in metastatic NSCLC during PD-1 or PD-L1 inhibitor therapy: Comparison of the RECIST 1.1 and iRECIST criteria
Q40346982Pembrolizumab as first-line therapy for patients with PD-L1-positive advanced non-small cell lung cancer: a phase 1 trial
Q42372526Pembrolizumab as first-line treatment for non-small cell lung cancer-a game changer?
Q64116168Peripheral T cell cytotoxicity predicts T cell function in the tumor microenvironment
Q89834907Predictive Value of Soluble PD-1, PD-L1, VEGFA, CD40 Ligand and CD44 for Nivolumab Therapy in Advanced Non-Small Cell Lung Cancer: A Case-Control Study
Q57191808Prognostic Factors for Checkpoint Inhibitor Based Immunotherapy: An Update With New Evidences
Q55311366Programmed cell death-1 and programmed cell death ligand-1 antibodies-induced dysthyroidism.
Q61817209Programmed death ligand 1 expression in early stage, resectable non-small cell lung cancer
Q52729304Programmed death ligand 1 testing in non-small cell lung carcinoma cytology cell block and aspirate smear preparations
Q52902960Progress of PD-1/PD-L1 Inhibitors in Non-small Cell Lung Cancer
Q41339254Pseudoprogression in microsatellite instability-high colorectal cancer during treatment with combination T cell mediated immunotherapy: a case report and literature review
Q50070316Putative predictors of efficacy for immune checkpoint inhibitors in non-small-cell lung cancer: facing the complexity of the immune system
Q91651231Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors
Q53641678Raising the bar on first-line immunotherapy in lung cancer
Q28069323Recent Advances in Immunotherapy in Metastatic NSCLC
Q92106808Recent Advances in Lung Cancer Immunotherapy: Input of T-Cell Epitopes Associated With Impaired Peptide Processing
Q38737954Relationship between expression of PD-L1 and tumor angiogenesis, proliferation, and invasion in glioma
Q38870763Releasing the brake: safety profile of immune check-point inhibitors in non-small cell lung cancer.
Q93083934Response to targeted therapy or chemotherapy following immunotherapy in patients with gastrointestinal cancers - a case series
Q50746388Response to the treatment immediately before nivolumab monotherapy may predict clinical response to nivolumab in patients with non-small cell lung cancer.
Q55359370Risk of hematologic toxicities with programmed cell death-1 inhibitors in cancer patients: a meta-analysis of current studies.
Q60489259Roles of the RANKL–RANK axis in antitumour immunity — implications for therapy
Q42275107SELECT-3: a phase I study of selumetinib in combination with platinum-doublet chemotherapy for advanced NSCLC in the first-line setting
Q92093081SOX7 regulates MAPK/ERK-BIM mediated apoptosis in cancer cells
Q89097028Safety and efficacy of concurrent immune checkpoint inhibitors and hypofractionated body radiotherapy
Q92685189Searching for a chemoimmunotherapy signal in patients with non-small-cell lung cancer and EGFR mutations
Q55362771Single nucleotide polymorphisms of casitas B-lineage lymphoma proto-oncogene-b predict outcomes of patients with advanced non-small cell lung cancer after first-line platinum based doublet chemotherapy.
Q94232616Single or combined immune checkpoint inhibitors compared to first‐line chemotherapy with or without bevacizumab for people with advanced non‐small cell lung cancer
Q36305457Successes and failures: what did we learn from recent first-line treatment immunotherapy trials in non-small cell lung cancer?
Q47712161Tackling Cancer Resistance by Immunotherapy: Updated Clinical Impact and Safety of PD-1/PD-L1 Inhibitors
Q39103431Targeting ALK: Precision Medicine Takes on Drug Resistance
Q58783242Targeting the PD-1/PD-L1 axis for the treatment of non-small-cell lung cancer
Q58779547The Expanding Role of Radiosurgery for Brain Metastases
Q64030468The Potential of In Vivo Imaging for Optimization of Molecular and Cellular Anti-cancer Immunotherapies
Q53835314The benefit and risk of nivolumab in non-small-cell lung cancer: a single-arm meta-analysis of noncomparative clinical studies and randomized controlled trials.
Q58561576The clinical role of the TME in solid cancer
Q38638860The evolutionary nature of the cancer immunotherapy revolution
Q93186621The evolving immuno-oncology landscape in advanced lung cancer: first-line treatment of non-small cell lung cancer
Q91520697The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy
Q33597192The expression and clinical relevance of PD-1, PD-L1, and TP63 in patients with diffuse large B-cell lymphoma
Q49795317The impact of PD-L1 on survival and value of the immune check point inhibitors in non-small-cell lung cancer; proposal, policies and perspective
Q38824489The next generation of immunotherapy: keeping lung cancer in check.
Q92463703The potential mechanism, recognition and clinical significance of tumor pseudoprogression after immunotherapy
Q38788124The safety of nivolumab for the treatment of advanced non-small cell lung cancer
Q50921394The second wave of immune checkpoint inhibitor tsunami: advance, challenges and perspectives
Q39172334Treatment of lung adenocarcinoma by molecular-targeted therapy and immunotherapy
Q90300273Treatment-Related Adverse Events of PD-1 and PD-L1 Inhibitors in Clinical Trials: A Systematic Review and Meta-analysis
Q47393365Trial watch: Immune checkpoint blockers for cancer therapy
Q55401255Tumor PD-L1 Expression and Clinical Outcomes in Advanced-stage Non-Small Cell Lung Cancer Patients Treated with Nivolumab or Pembrolizumab: Real-World Data in Taiwan.
Q50544077Tumor-targeted IL-12 combined with local irradiation leads to systemic tumor control via abscopal effects in vivo
Q38604723Use of programmed cell death protein ligand 1 assay to predict the outcomes of non-small cell lung cancer patients treated with immune checkpoint inhibitors
Q38619196β-adrenergic signaling in mice housed at standard temperatures suppresses an effector phenotype in CD8(+) T cells and undermines checkpoint inhibitor therapy.

Search more.