Proneurotrophins require endocytosis and intracellular proteolysis to induce TrkA activation

scientific article published on 25 February 2008

Proneurotrophins require endocytosis and intracellular proteolysis to induce TrkA activation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M710018200
P932PMC publication ID2442317
P698PubMed publication ID18299325

P2093author name stringPhilip A Barker
Kenneth E Neet
Claire Ceni
Alison Forgie
Jacqueline Boutilier
Promila C Pagdala
P2860cites workAlkaline phosphatase fusion proteins for molecular characterization and cloning of receptors and their ligandsQ73110172
Sympathetic neurons synthesize and secrete pro-nerve growth factor proteinQ73940758
NGF signaling from clathrin-coated vesicles: evidence that signaling endosomes serve as a platform for the Ras-MAPK pathwayQ77334867
Oxidative folding of nerve growth factor can be mediated by the pro-peptide of neurotrophin-3Q80794713
Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiationQ22254658
A PACS-1, GGA3 and CK2 complex regulates CI-MPR traffickingQ24303415
Sortilin is essential for proNGF-induced neuronal cell deathQ24312692
Mutations within a furin consensus sequence block proteolytic release of ectodysplasin-A and cause X-linked hypohidrotic ectodermal dysplasiaQ24631099
The phosphorylation state of an autoregulatory domain controls PACS-1-directed protein trafficQ24634247
Neurotrophins: roles in neuronal development and functionQ24656166
Furin at the cutting edge: from protein traffic to embryogenesis and diseaseQ24670432
Regulation of cell survival by secreted proneurotrophinsQ27919620
Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosomeQ28201387
p75 neurotrophin receptor expression is induced in apoptotic neurons after seizureQ28370410
ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injuryQ28574864
Neurotrophins and their receptors: a convergence point for many signalling pathwaysQ29616108
Furin initiates gelsolin familial amyloidosis in the Golgi through a defect in Ca(2+) stabilizationQ34078036
Neurotrophin signaling through the p75 neurotrophin receptorQ34778209
Construction of a mutated pro-nerve growth factor resistant to degradation and suitable for biophysical and cellular utilizationQ35215109
Signaling endosome hypothesis: A cellular mechanism for long distance communicationQ35620199
Regulation of Notch signalling by endocytosis and endosomal sortingQ36401081
Promoting neurotrophic effects by GPCR ligands.Q36521730
Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injuryQ37647649
Nerve growth factor and its precursor differentially regulate hair cycle progression in miceQ40406447
Inhibition of the membrane fusion machinery prevents exit from the TGN and proteolytic processing by furinQ40780580
Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertasesQ41229731
Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formationQ41570746
The pro-peptide of proNGF: structure formation and intramolecular association with NGF.Q42098632
Pro-brain-derived neurotrophic factor is decreased in parietal cortex in Alzheimer's disease.Q42438737
The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's diseaseQ42509117
Activation of p75NTR by proBDNF facilitates hippocampal long-term depressionQ46604995
The nerve growth factor precursor proNGF exhibits neurotrophic activity but is less active than mature nerve growth factorQ47758744
Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease.Q48871284
'Mature' nerve growth factor is a minor species in most peripheral tissuesQ48912214
The secreted brain-derived neurotrophic factor precursor pro-BDNF binds to TrkB and p75NTR but not to TrkA or TrkC.Q49062410
Mature pig oligodendrocytes rapidly process human recombinant pro-nerve growth factor and do not undergo cell death.Q50478407
The antibody to GD3 ganglioside, R24, is rapidly endocytosed and recycled to the plasma membrane via the endocytic recycling compartment. Inhibitory effect of brefeldin A and monensin.Q51808362
Structural and functional properties of mouse proNGF.Q54459237
P433issue19
P407language of work or nameEnglishQ1860
P921main subjectproteolysisQ33123
P304page(s)12709-12716
P577publication date2008-02-25
P1433published inJournal of Biological ChemistryQ867727
P1476titleProneurotrophins require endocytosis and intracellular proteolysis to induce TrkA activation
P478volume283

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cites work (P2860)
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